STRINGSTRING
MTERF2 MTERF2 SIRT5 SIRT5 GLUD2 GLUD2 CHD9 CHD9 LOC104665620 LOC104665620 TFB1M TFB1M CARM1 CARM1 TWNK TWNK IDH2 IDH2 GABPA GABPA TGS1 TGS1 CREB1 CREB1 GABPB2 GABPB2 ATP5F1B ATP5F1B SIRT3 SIRT3 ENSRROP00000029359 ENSRROP00000029359 MED1 MED1 CRTC2 CRTC2 SMARCD3 SMARCD3 ENSRROP00000030592 ENSRROP00000030592 GLUD1 GLUD1 ESRRA ESRRA NCOR1 NCOR1 CRTC1 CRTC1 NCOA2 NCOA2 CRTC3 CRTC3 ENSRROP00000033788 ENSRROP00000033788 POLRMT POLRMT MEF2C MEF2C NCOA1 NCOA1 ENSRROP00000036753 ENSRROP00000036753 ENSRROP00000039005 ENSRROP00000039005 RXRA RXRA TBL1XR1 TBL1XR1 ENSRROP00000045774 ENSRROP00000045774 MTERF1 MTERF1 NRF1 NRF1 TBL1X TBL1X NCOA6 NCOA6 ACSS2 ACSS2 PPARGC1B PPARGC1B ATF2 ATF2 SSBP1 SSBP1 SIRT4 SIRT4 POLG2 POLG2 SOD2 SOD2 ENSRROP00000007257 ENSRROP00000007257 LOC104661761 LOC104661761 ENSRROP00000007230 ENSRROP00000007230 SRFBP1 SRFBP1 LOC104672188 LOC104672188 HDAC3 HDAC3 LOC104670765 LOC104670765 NR1D1 NR1D1 ENSRROP00000005469 ENSRROP00000005469 GABPB1 GABPB1 LOC104682414 LOC104682414 CAMK4 CAMK4 TFB2M TFB2M ENSRROP00000002717 ENSRROP00000002717 ALAS1 ALAS1 PPARGC1A PPARGC1A HELZ2 HELZ2 MEF2D MEF2D LOC104681924 LOC104681924 HCFC1 HCFC1 CREBBP CREBBP LOC104679886 LOC104679886 PPARA PPARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTERF2Mitochondrial transcription termination factor 2. (385 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (537 aa)
CHD9Uncharacterized protein. (2395 aa)
LOC104665620Uncharacterized protein. (248 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (337 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (564 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (449 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
TGS1Trimethylguanosine synthase 1. (855 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GABPB2GA binding protein transcription factor subunit beta 2. (404 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (535 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
ENSRROP00000029359Uncharacterized protein. (71 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
CRTC2CREB regulated transcription coactivator 2. (699 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (386 aa)
ENSRROP00000030592Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (562 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
CRTC1CREB regulated transcription coactivator 1. (608 aa)
NCOA2Nuclear receptor coactivator. (1475 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
ENSRROP00000033788Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (91 aa)
POLRMTDNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1249 aa)
MEF2CMyocyte enhancer factor 2C. (466 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ENSRROP00000036753ELFV_dehydrog domain-containing protein. (150 aa)
ENSRROP00000039005Uncharacterized protein. (450 aa)
RXRARetinoid X receptor alpha. (481 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
ENSRROP00000045774Uncharacterized protein. (388 aa)
MTERF1Mitochondrial transcription termination factor 1. (399 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
TBL1XTransducin beta like 1 X-linked. (575 aa)
NCOA6Nuclear receptor coactivator 6. (2069 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ENSRROP00000007257Uncharacterized protein. (66 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
ENSRROP00000007230Uncharacterized protein. (193 aa)
SRFBP1Serum response factor binding protein 1. (429 aa)
LOC104672188Cytochrome c. (105 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
LOC104670765Uncharacterized protein. (248 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ENSRROP00000005469Uncharacterized protein. (53 aa)
GABPB1GA binding protein transcription factor subunit beta 1. (383 aa)
LOC104682414WD_REPEATS_REGION domain-containing protein. (489 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (274 aa)
TFB2MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (396 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ALAS15-aminolevulinate synthase. (640 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
HELZ2Helicase with zinc finger 2. (2822 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HCFC1Host cell factor C1. (2080 aa)
CREBBPCREB binding protein. (2442 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PPARAPeroxisome proliferator activated receptor alpha. (398 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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