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| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | EP300 | E1A binding protein p300. (2413 aa) |
| | NUAK2 | NUAK family kinase 2. (672 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | LOC104677352 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (697 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | C17orf113 | Chromosome 17 open reading frame 113. (675 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (526 aa) |
| | LOC104655794 | Transcription initiation factor TFIID subunit 13. (124 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (167 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | AURKA | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | BRPF1 | Uncharacterized protein. (1247 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (560 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (220 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | RNF34 | Ring finger protein 34. (376 aa) |
| | ENSRROP00000033818 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (446 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (800 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSRROP00000034546 | Uncharacterized protein. (94 aa) |
| | RECQL4 | RecQ like helicase 4. (1150 aa) |
| | ENSRROP00000035203 | Ubiquitin-like domain-containing protein. (141 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1968 aa) |
| | PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | ENSRROP00000035521 | WD_REPEATS_REGION domain-containing protein. (356 aa) |
| | NUAK1 | NUAK family kinase 1. (667 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | MDM2 | Uncharacterized protein. (513 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa) |
| | TXNDC11 | Thioredoxin domain containing 11. (900 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (738 aa) |
| | ENSRROP00000000782 | Metallophos domain-containing protein. (229 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | LOC104657230 | Ubiquitin-like domain-containing protein. (156 aa) |
| | BANP | BTG3 associated nuclear protein. (519 aa) |
| | TP53RK | TP53 regulating kinase. (253 aa) |
| | LOC104659073 | Ubiquitin-like domain-containing protein. (76 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (211 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (356 aa) |
| | LOC104657153 | Ubiquitin-like domain-containing protein. (128 aa) |
| | PRR5 | Proline rich 5. (410 aa) |
| | ENSRROP00000003296 | Ubiquitin-like domain-containing protein. (96 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (520 aa) |
| | LOC104664221 | Uncharacterized protein. (240 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa) |
| | PLK5 | Polo like kinase 5. (312 aa) |
| | PML | Promyelocytic leukemia. (882 aa) |
| | ENSRROP00000004482 | Uncharacterized protein. (159 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | LOC104674542 | Uncharacterized protein. (264 aa) |
| | ENSRROP00000005185 | Uncharacterized protein. (120 aa) |
| | PHF20 | PHD finger protein 20. (1010 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | ENSRROP00000005625 | Ubiquitin-like domain-containing protein. (84 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | ENSRROP00000005750 | Ubiquitin-like domain-containing protein. (77 aa) |
| | MAPKAP1 | MAPK associated protein 1. (522 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (931 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (788 aa) |
| | ATRIP | ATR interacting protein. (791 aa) |
| | ENSRROP00000006154 | Uncharacterized protein. (163 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | ZNF385A | Zinc finger protein 385A. (386 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (752 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1034 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1237 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | RAD1 | Uncharacterized protein. (280 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2059 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (592 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (593 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1197 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2014 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (473 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (862 aa) |
| | ENSRROP00000011768 | Peptidyl-prolyl cis-trans isomerase. (154 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | POU4F1 | POU domain protein. (286 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | RFFL | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (363 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (590 aa) |
| | ENSRROP00000013107 | Uncharacterized protein. (128 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa) |
| | ENSRROP00000013523 | TAFII28 domain-containing protein. (210 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | ENSRROP00000013712 | Bromo domain-containing protein. (522 aa) |
| | TAF1 | TATA-box binding protein associated factor 1. (1196 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (988 aa) |
| | BRD7 | Bromo domain-containing protein. (652 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (312 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1134 aa) |
| | ING5 | Inhibitor of growth family member 5. (254 aa) |
| | GATAD2A | GATA-type domain-containing protein. (648 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (277 aa) |
| | L3MBTL1 | Uncharacterized protein. (832 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (335 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (727 aa) |
| | BRD1 | Bromodomain containing 1. (1189 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | L3MBTL3 | L3MBTL histone methyl-lysine binding protein 3. (780 aa) |
| | DAXX | Daxx domain-containing protein. (744 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | PRDM1 | PR/SET domain 1. (825 aa) |
| | ENSRROP00000018012 | P66_CC domain-containing protein. (587 aa) |
| | ENSRROP00000018027 | Uncharacterized protein. (309 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | LOC104669754 | Uncharacterized protein. (124 aa) |
| | UBC | Uncharacterized protein. (351 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | MEAF6 | Uncharacterized protein. (262 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | ENSRROP00000019405 | Hist_deacetyl domain-containing protein. (352 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | ENSRROP00000044392 | Uncharacterized protein. (440 aa) |
| | ENSRROP00000044391 | WD_REPEATS_REGION domain-containing protein. (379 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (339 aa) |
| | ENSRROP00000043193 | Protein kinase domain-containing protein. (377 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | CSNK2B | Uncharacterized protein. (298 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (673 aa) |
| | USP7 | Uncharacterized protein; Belongs to the peptidase C19 family. (1102 aa) |
| | EHMT1 | Euchromatic histone lysine methyltransferase 1. (1281 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | MBD3 | Methyl-CpG binding domain protein 3. (196 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | FOXP4 | Forkhead box P4. (680 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (580 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (635 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1215 aa) |
| | RFC2 | Replication factor C subunit 2. (332 aa) |
| | RHNO1 | Uncharacterized protein. (240 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1087 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ENSRROP00000038862 | Protein kinase domain-containing protein. (265 aa) |
| | ENSRROP00000038550 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1251 aa) |
| | L3MBTL4 | L3MBTL histone methyl-lysine binding protein 4. (623 aa) |
| | CHD4 | Uncharacterized protein. (1913 aa) |
| | ENSRROP00000037750 | Ubiquitin-like domain-containing protein. (121 aa) |
| | LOC104653719 | Bromo domain-containing protein. (592 aa) |
| | ENSRROP00000036868 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (406 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | SETD9 | SET domain containing 9. (299 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | PPP1R13L | Uncharacterized protein. (389 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1205 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (635 aa) |
| | SMYD2 | SET and MYND domain containing 2. (416 aa) |
| | LOC104675025 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (241 aa) |
| | AIRE | Autoimmune regulator. (547 aa) |
| | ZNF385C | Zinc finger protein 385C. (500 aa) |
| | ENSRROP00000021317 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (374 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ENSRROP00000021443 | Uncharacterized protein. (231 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | ENSRROP00000021770 | Ubiquitin-like domain-containing protein. (166 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (463 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa) |
| | CHEK2 | Checkpoint kinase 2. (589 aa) |
| | RMI2 | Uncharacterized protein. (83 aa) |
| | TTC5 | Tetratricopeptide repeat domain 5. (461 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | ING1 | Inhibitor of growth protein. (406 aa) |
| | ENSRROP00000023864 | Uncharacterized protein. (115 aa) |
| | ENSRROP00000024190 | Protein kinase domain-containing protein. (137 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | LOC104679892 | BRCT domain-containing protein. (96 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa) |
| | ENSRROP00000024732 | Uncharacterized protein. (252 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ENSRROP00000026126 | Ubiquitin-like domain-containing protein. (77 aa) |
| | KMT5A | Lysine methyltransferase 5A. (346 aa) |
| | BRD9 | Bromodomain containing 9. (550 aa) |
| | ENSRROP00000026439 | WD_REPEATS_REGION domain-containing protein. (363 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa) |
| | TBP | TATA-box binding protein. (333 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1695 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa) |
