STRINGSTRING
AGO2 AGO2 ABCG5 ABCG5 ANGPTL3 ANGPTL3 LOC104682414 LOC104682414 ENSRROP00000005469 ENSRROP00000005469 HDAC3 HDAC3 KDM4A KDM4A ENSRROP00000007230 ENSRROP00000007230 NRIP1 NRIP1 APOE APOE ARL4C ARL4C TBL1X TBL1X ENSRROP00000012874 ENSRROP00000012874 TNRC6B TNRC6B APOC4 APOC4 FABP6 FABP6 ENSRROP00000017874 ENSRROP00000017874 PLIN1 PLIN1 MYLIP MYLIP AGO4 AGO4 ARL4A ARL4A EP300 EP300 EEPD1 EEPD1 ABCA1 ABCA1 SREBF1 SREBF1 NCOR1 NCOR1 SCD SCD LOC104673462 LOC104673462 CETP CETP PCK1 PCK1 NR1H2 NR1H2 GPS2 GPS2 KDM1A KDM1A ENSRROP00000035150 ENSRROP00000035150 MOV10 MOV10 RXRB RXRB KDM3A KDM3A NCOA1 NCOA1 PLTP PLTP AGO3 AGO3 NCOR2 NCOR2 RXRA RXRA TBL1XR1 TBL1XR1 FASN FASN AGO1 AGO1 ABCG8 ABCG8 APOD APOD ABCG1 ABCG1 NR1H3 NR1H3 APOC2 APOC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
LOC104682414WD_REPEATS_REGION domain-containing protein. (489 aa)
ENSRROP00000005469Uncharacterized protein. (53 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
KDM4AUncharacterized protein. (1064 aa)
ENSRROP00000007230Uncharacterized protein. (193 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ARL4CADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (202 aa)
TBL1XTransducin beta like 1 X-linked. (575 aa)
ENSRROP00000012874Uncharacterized protein. (205 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1832 aa)
APOC4Uncharacterized protein. (127 aa)
FABP6Fatty acid binding protein 6. (163 aa)
ENSRROP00000017874Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (348 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
MYLIPMyosin regulatory light chain interacting protein. (462 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (828 aa)
ARL4AADP ribosylation factor like GTPase 4A. (200 aa)
EP300E1A binding protein p300. (2413 aa)
EEPD1Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
SCDUncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (359 aa)
LOC104673462Uncharacterized protein. (130 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
GPS2G protein pathway suppressor 2. (327 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
ENSRROP00000035150Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (200 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
RXRBRetinoid X receptor beta. (542 aa)
KDM3ALysine demethylase 3A. (1322 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PLTPPhospholipid transfer protein. (493 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
NCOR2Nuclear receptor corepressor 2. (2522 aa)
RXRARetinoid X receptor alpha. (481 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
FASNFatty acid synthase. (2504 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
ABCG8ATP binding cassette subfamily G member 8. (673 aa)
APODApolipoprotein D. (215 aa)
ABCG1ATP binding cassette subfamily G member 1. (677 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (511 aa)
APOC2Apolipoprotein C2. (119 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (26%) [HD]