STRINGSTRING
SCN1A SCN1A CACNA1S CACNA1S TRPM5 TRPM5 RYR3 RYR3 TRPA1 TRPA1 NALCN NALCN CNGA1 CNGA1 CACNA1I CACNA1I TRPM8 TRPM8 CNGA4 CNGA4 SCN2A SCN2A CACNA1F CACNA1F HCN3 HCN3 ITPR3 ITPR3 RYR2 RYR2 SCN11A SCN11A PKD2L1 PKD2L1 TRPV3 TRPV3 ENSRROP00000039493 ENSRROP00000039493 CACNA1G CACNA1G CACNA1B CACNA1B ITPR1 ITPR1 TRPV6 TRPV6 TRPM4 TRPM4 SCN10A SCN10A TPCN1 TPCN1 CACNA1H CACNA1H TRPV2 TRPV2 HCN2 HCN2 TRPM3 TRPM3 TRPC4 TRPC4 KCNA2 KCNA2 CNGA3 CNGA3 SCN5A SCN5A TPCN2 TPCN2 PKD2L2 PKD2L2 CACNA1E CACNA1E PKD2 PKD2 TRPM1 TRPM1 CNGA2 CNGA2 TRPM7 TRPM7 TRPM6 TRPM6 TRPV1 TRPV1 ENSRROP00000017395 ENSRROP00000017395 TRPM2 TRPM2 ENSRROP00000019238 ENSRROP00000019238 TRPV5 TRPV5 HCN1 HCN1 ITPR2 ITPR2 CACNA1D CACNA1D CATSPER3 CATSPER3 SCN4A SCN4A SCN3A SCN3A SCN9A SCN9A TRPC5 TRPC5 HVCN1 HVCN1 SCN8A SCN8A SCN7A SCN7A TRPV4 TRPV4 CACNA1A CACNA1A HCN4 HCN4 RYR1 RYR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1154 aa)
RYR3Ryanodine receptor 3. (4851 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1116 aa)
NALCNSodium leak channel, non-selective. (1738 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (758 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2187 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1971 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (774 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
RYR2Ryanodine receptor 2. (4938 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1791 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
ENSRROP00000039493Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (814 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2301 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (765 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1326 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
TPCN1Two pore segment channel 1. (879 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (865 aa)
TRPM3Transient receptor potential cation channel subfamily M member 3. (1712 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (356 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
TPCN2Two pore segment channel 2. (752 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1643 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (2011 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (853 aa)
ENSRROP00000017395Ion_trans domain-containing protein. (313 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
ENSRROP00000019238Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (785 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (729 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (885 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CATSPER3Cation channel sperm associated 3. (337 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5. (848 aa)
HVCN1Hydrogen voltage gated channel 1. (273 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1991 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1494 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2426 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
RYR1Ryanodine receptor 1. (4931 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.