STRINGSTRING
ADCY8 ADCY8 AKT1 AKT1 BRAF BRAF LOC104670080 LOC104670080 ADCY5 ADCY5 E2F3 E2F3 MAPK8 MAPK8 PRKACB PRKACB BAX BAX MAPK9 MAPK9 SHC4 SHC4 ADCY1 ADCY1 SP1 SP1 E2F2 E2F2 CDK4 CDK4 PRKACA PRKACA HBEGF HBEGF PIK3CA PIK3CA DLL1 DLL1 PIK3CD PIK3CD ADCY2 ADCY2 SOS1 SOS1 JAG1 JAG1 MAP2K2 MAP2K2 NOTCH4 NOTCH4 SHC1 SHC1 CCND1 CCND1 NRAS NRAS IGF1R IGF1R CARM1 CARM1 SRC SRC BAD BAD MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 ABCB11 ABCB11 RB1 RB1 GPER1 GPER1 MAPK1 MAPK1 MTOR MTOR DLL3 DLL3 IGF1 IGF1 MAPK14 MAPK14 SOS2 SOS2 ADCY9 ADCY9 CDKN1B CDKN1B TP53 TP53 CDKN2A CDKN2A CDKN1A CDKN1A NOTCH2 NOTCH2 MAPK10 MAPK10 BIK BIK FOS FOS MMP2 MMP2 MED1 MED1 PIK3R3 PIK3R3 E2F1 E2F1 NCOR1 NCOR1 MAPK3 MAPK3 ESR2 ESR2 PTK2 PTK2 KRAS KRAS GRB2 GRB2 RPS6KB1 RPS6KB1 BCL2 BCL2 HRAS HRAS ADCY7 ADCY7 EGFR EGFR RAF1 RAF1 LOC104663799 LOC104663799 GNAS GNAS ARAF ARAF AKT2 AKT2 ADCY6 ADCY6 ADCY3 ADCY3 NOTCH1 NOTCH1 CDKN2C CDKN2C NOTCH3 NOTCH3 NCOA3 NCOA3 RPS6KB2 RPS6KB2 PIK3CB PIK3CB LOC104678360 LOC104678360 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
LOC104670080Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
E2F3E2F transcription factor 3. (465 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
SHC4SHC adaptor protein 4. (630 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
SP1Sp1 transcription factor. (786 aa)
E2F2E2F transcription factor 2. (437 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
NOTCH4Notch receptor 4. (2037 aa)
SHC1SHC adaptor protein 1. (574 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (564 aa)
SRCTyrosine-protein kinase. (540 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
RB1RB transcriptional corepressor 1. (929 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NOTCH2Notch receptor 2. (2471 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
BIKBCL2 interacting killer. (157 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F1E2F transcription factor 1. (485 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ESR2Estrogen receptor 2. (530 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RAF1Uncharacterized protein. (668 aa)
LOC104663799Uncharacterized protein. (246 aa)
GNASGNAS complex locus. (1041 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
NOTCH1Notch receptor 1. (2560 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
NOTCH3Notch receptor 3. (2336 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC104678360Nuclear receptor domain-containing protein. (231 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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