(44 nodes) Proteasome network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMB10	Proteasome subunit beta. (273 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	LOC104658905	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (350 aa)
	PSMB8	Proteasome subunit beta. (308 aa)
	PSMB11	Proteasome subunit beta. (300 aa)
	PSMB6	Proteasome subunit beta. (242 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (324 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (422 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	PSMC2	AAA domain-containing protein; Belongs to the AAA ATPase family. (467 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	PSMB5	Proteasome subunit beta. (271 aa)
	PSME3	Proteasome activator subunit 3. (267 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (315 aa)
	POMP	Uncharacterized protein. (160 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (534 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	PSMA3	Proteasome subunit alpha type. (277 aa)
	PSMC3	AAA domain-containing protein; Belongs to the AAA ATPase family. (447 aa)
	PSMD9	PDZ domain-containing protein. (223 aa)
	SEM1-2	Uncharacterized protein. (89 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (389 aa)
	PSMA7	Proteasome endopeptidase complex. (248 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMB7	Proteasome subunit beta. (302 aa)
	PSME4	Proteasome activator subunit 4. (1844 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (444 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (399 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (378 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNG	PSMB8	ENSRROP00000017582	ENSRROP00000004658	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome subunit beta.	0.565
IFNG	PSMB9	ENSRROP00000017582	ENSRROP00000001314	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome subunit beta.	0.564
IFNG	PSMD3	ENSRROP00000017582	ENSRROP00000023328	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome 26S subunit, non-ATPase 3.	0.413
IFNG	PSME1	ENSRROP00000017582	ENSRROP00000042549	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome activator subunit 1.	0.940
IFNG	PSME2	ENSRROP00000017582	ENSRROP00000029867	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome activator subunit 2.	0.924
IFNG	PSME3	ENSRROP00000017582	ENSRROP00000020752	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteasome activator subunit 3.	0.921
LOC104658905	PSMA1	ENSRROP00000002058	ENSRROP00000027914	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.818
LOC104658905	PSMA2	ENSRROP00000002058	ENSRROP00000014521	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.762
LOC104658905	PSMA3	ENSRROP00000002058	ENSRROP00000034289	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.892
LOC104658905	PSMA4	ENSRROP00000002058	ENSRROP00000033382	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.886
LOC104658905	PSMA5	ENSRROP00000002058	ENSRROP00000032266	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.910
LOC104658905	PSMA6	ENSRROP00000002058	ENSRROP00000039745	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.793
LOC104658905	PSMA7	ENSRROP00000002058	ENSRROP00000039636	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome endopeptidase complex.	0.859
LOC104658905	PSMA8	ENSRROP00000002058	ENSRROP00000003674	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.839
LOC104658905	PSMB1	ENSRROP00000002058	ENSRROP00000024809	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.873
LOC104658905	PSMB10	ENSRROP00000002058	ENSRROP00000001101	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.773
LOC104658905	PSMB11	ENSRROP00000002058	ENSRROP00000006624	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.737
LOC104658905	PSMB2	ENSRROP00000002058	ENSRROP00000009340	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.898
LOC104658905	PSMB3	ENSRROP00000002058	ENSRROP00000034101	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.780
LOC104658905	PSMB4	ENSRROP00000002058	ENSRROP00000010982	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.888