STRINGSTRING
LOC104655958 LOC104655958 RGS2 RGS2 ADCY8 ADCY8 MEF2D MEF2D AKT1 AKT1 MYLK MYLK ATP2B4 ATP2B4 MYL9 MYL9 ATF6B ATF6B ADCY5 ADCY5 ATP2A1 ATP2A1 GUCY1A1 GUCY1A1 ADRA2B ADRA2B NFATC4 NFATC4 CALML3 CALML3 ATP1B4 ATP1B4 ADRB2 ADRB2 PLN PLN VDAC1 VDAC1 GNA13 GNA13 ATP2B1 ATP2B1 MYH7 MYH7 SLC8A3 SLC8A3 ATF4 ATF4 EDNRA EDNRA SLC8A1 SLC8A1 NFATC1 NFATC1 PDE3A PDE3A ADORA1 ADORA1 PPP1R12A PPP1R12A PRKCE PRKCE NPPA NPPA ADCY1 ADCY1 GNAI2 GNAI2 ATF2 ATF2 OPRD1 OPRD1 PIK3R6 PIK3R6 ATP1B3 ATP1B3 ADCY2 ADCY2 ATP1A3 ATP1A3 PDE3B PDE3B AGTR1 AGTR1 PPP3R1 PPP3R1 MAP2K2 MAP2K2 MYH6 MYH6 ATP1B1 ATP1B1 EDNRB EDNRB RHOA RHOA PIK3CG PIK3CG KCNMB2 KCNMB2 PRKG2 PRKG2 PPP3CB PPP3CB GNA11 GNA11 NPPB NPPB CREB5 CREB5 GNAI3 GNAI3 KNG1 KNG1 NPR1 NPR1 ATP1A2 ATP1A2 ADRA1B ADRA1B CALM3 CALM3 ATP2B2 ATP2B2 GNAI1 GNAI1 MEF2B MEF2B PLCB3 PLCB3 ENSRROP00000019822 ENSRROP00000019822 BAD BAD SRF SRF MAP2K1 MAP2K1 GTF2I GTF2I NOS3 NOS3 NFATC3 NFATC3 AKT3 AKT3 ATP1A4 ATP1A4 ROCK2 ROCK2 SLC25A4 SLC25A4 PLCB1 PLCB1 CREB3 CREB3 CREB1 CREB1 KCNMB4 KCNMB4 ITPR2 ITPR2 CACNA1D CACNA1D NPR2 NPR2 PPIF PPIF MAPK1 MAPK1 VDAC2 VDAC2 CACNA1S CACNA1S TRPC6 TRPC6 KCNJ8 KCNJ8 PLCB4 PLCB4 ADCY9 ADCY9 PPP3CC PPP3CC IRS4 IRS4 PPP1CB PPP1CB LOC104661254 LOC104661254 MYLK4 MYLK4 GUCY1B1 GUCY1B1 SLC25A6 SLC25A6 CACNA1C CACNA1C PDE5A PDE5A ATP2A3 ATP2A3 INSR INSR KCNMB1 KCNMB1 MAPK3 MAPK3 LOC104662055 LOC104662055 PPP1CA PPP1CA CNGA1 CNGA1 BDKRB2 BDKRB2 INS INS CACNA1F CACNA1F GNAQ GNAQ ADRA1A ADRA1A ITPR3 ITPR3 ADCY7 ADCY7 CREB3L1 CREB3L1 MYLK2 MYLK2 RAF1 RAF1 PDE2A PDE2A CNGB1 CNGB1 MRVI1 MRVI1 NFATC2 NFATC2 ATP1B2 ATP1B2 AKT2 AKT2 ADCY6 ADCY6 ADCY3 ADCY3 ATP2B3 ATP2B3 PRKG1 PRKG1 ROCK1 ROCK1 PPP1CC PPP1CC VDAC3 VDAC3 CALML6 CALML6 PIK3R5 PIK3R5 GNA12 GNA12 VASP VASP ATP2A2 ATP2A2 FXYD2 FXYD2 MYLK3 MYLK3 ATP1A1 ATP1A1 ITPR1 ITPR1 NPPC NPPC CREB3L2 CREB3L2 CALML4 CALML4 SLC8A2 SLC8A2 PPP3CA PPP3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC104655958Uncharacterized protein. (423 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYLKMyosin light chain kinase. (1911 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
MYL9Myosin light chain 9. (172 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ADRA2BAdrenoceptor alpha 2B. (448 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
GNA13G protein subunit alpha 13. (308 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1033 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
ATF4Activating transcription factor 4. (351 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
PDE3APhosphodiesterase. (1141 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (907 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
NPPANatriuretic peptide A. (153 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1248 aa)
PDE3BPhosphodiesterase. (1113 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
RHOARas homolog family member A. (193 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
KCNMB2Uncharacterized protein. (216 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
GNA11G protein subunit alpha 11. (359 aa)
NPPBNatriuretic peptide B. (134 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNAI3G protein subunit alpha i3. (354 aa)
KNG1Kininogen 1. (644 aa)
NPR1Guanylate cyclase. (1284 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1063 aa)
ADRA1BAdrenoceptor alpha 1B. (512 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1270 aa)
GNAI1G protein subunit alpha i1. (253 aa)
MEF2BMyocyte enhancer factor 2B. (368 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SRFSerum response factor. (508 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
NPR2Guanylate cyclase. (1047 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
IRS4Insulin receptor substrate 4. (1227 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
LOC104661254Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (642 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CACNA1CCa_chan_IQ domain-containing protein. (829 aa)
PDE5APhosphodiesterase. (875 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (204 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (758 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1971 aa)
GNAQG protein subunit alpha q. (359 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
RAF1Uncharacterized protein. (668 aa)
PDE2APhosphodiesterase. (941 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1236 aa)
MRVI1Murine retrovirus integration site 1 homolog. (911 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (463 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
VDAC3Uncharacterized protein. (284 aa)
CALML6Calmodulin like 6. (181 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
GNA12G protein subunit alpha 12. (381 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (143 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
NPPCNatriuretic peptide C. (126 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CALML4Calmodulin like 4. (192 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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