STRINGSTRING
GSK3B GSK3B CCR5 CCR5 ADCY8 ADCY8 XCR1 XCR1 CXCL5 CXCL5 AKT1 AKT1 IKBKG IKBKG GNGT1 GNGT1 BRAF BRAF GRK4 GRK4 CXCL10 CXCL10 CCL7 CCL7 ADCY5 ADCY5 RASGRP2 RASGRP2 RELA RELA LOC104680017 LOC104680017 GSK3A GSK3A JAK3 JAK3 CXCR6 CXCR6 PRKACB PRKACB GNB3 GNB3 CCR4 CCR4 LYN LYN CCL27 CCL27 LOC104668961 LOC104668961 FOXO3 FOXO3 SHC4 SHC4 TIAM1 TIAM1 GNG7 GNG7 CCL19 CCL19 ADCY1 ADCY1 GNAI2 GNAI2 CXCR4 CXCR4 PARD3 PARD3 PIK3R6 PIK3R6 JAK2 JAK2 GNG13 GNG13 PRKACA PRKACA RAP1B RAP1B PIK3CA PIK3CA PRKCD PRKCD STAT5B STAT5B PIK3CD PIK3CD ADCY2 ADCY2 CCR1 CCR1 VAV1 VAV1 CCR6 CCR6 GRK3 GRK3 SOS1 SOS1 STAT2 STAT2 CCL17 CCL17 CCL8 CCL8 VAV2 VAV2 NFKBIB NFKBIB CCL14 CCL14 CCL16 CCL16 GNB1 GNB1 CXCL16 CXCL16 RHOA RHOA PIK3CG PIK3CG BCAR1 BCAR1 SHC1 SHC1 PF4 PF4 LOC104658882 LOC104658882 CCL20 CCL20 GRK2 GRK2 GRK1 GRK1 GNAI3 GNAI3 CCL4 CCL4 CCR10 CCR10 NRAS NRAS STAT3 STAT3 CCL21 CCL21 LOC104654808 LOC104654808 CCR3 CCR3 GNAI1 GNAI1 PLCB3 PLCB3 SRC SRC BAD BAD PRKCB PRKCB MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 CXCL6 CXCL6 ROCK2 ROCK2 VAV3 VAV3 PLCB1 PLCB1 CRK CRK CCL26 CCL26 PREX1 PREX1 DOCK2 DOCK2 MAPK1 MAPK1 PLCG1 PLCG1 LOC104664497 LOC104664497 IKBKB IKBKB CXCL1 CXCL1 CCL1 CCL1 CXCR5 CXCR5 ITK ITK SOS2 SOS2 PLCB4 PLCB4 NCF1 NCF1 NFKBIA NFKBIA ADCY9 ADCY9 CCL28 CCL28 GNG3 GNG3 ARRB1 ARRB1 LOC104668962 LOC104668962 PPBP PPBP CXCR3 CXCR3 CCR9 CCR9 CCR2 CCR2 CX3CR1 CX3CR1 CCL23 CCL23 CCR7 CCR7 GRK7 GRK7 PIK3R3 PIK3R3 ARRB2 ARRB2 GNB5 GNB5 PF4V1 PF4V1 MAPK3 MAPK3 GNG4 GNG4 PTK2 PTK2 KRAS KRAS CXCL11 CXCL11 FGR FGR STAT1 STAT1 GRB2 GRB2 CCL25 CCL25 CXCL12 CXCL12 CDC42 CDC42 GNG5 GNG5 GNAQ GNAQ WAS WAS HRAS HRAS GNB4 GNB4 ELMO1 ELMO1 ADCY7 ADCY7 CX3CL1 CX3CL1 LOC104678227 LOC104678227 CCL13 CCL13 RAF1 RAF1 CCL18 CCL18 CHUK CHUK GNG11 GNG11 CXCL13 CXCL13 PRKCZ PRKCZ PTK2B PTK2B RAP1A RAP1A RAC2 RAC2 CRKL CRKL AKT2 AKT2 GNB2 GNB2 ADCY6 ADCY6 ADCY3 ADCY3 ROCK1 ROCK1 GRK5 GRK5 HCK HCK CCL24 CCL24 GNG12 GNG12 LOC104654807 LOC104654807 PIK3R5 PIK3R5 PIK3CB PIK3CB CXCL2 CXCL2 CCL22 CCL22 PLCG2 PLCG2 PAK1 PAK1 GNG8 GNG8 CXCL8 CXCL8 NFKB1 NFKB1 GRK6 GRK6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CXCL5C-X-C motif chemokine. (114 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
GRK4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (546 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CCL7C-C motif chemokine. (99 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
RASGRP2RAS guanyl releasing protein 2. (621 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC104680017Uncharacterized protein. (87 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (428 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
CXCR6C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (343 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB3G protein subunit beta 3. (340 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LYNTyrosine-protein kinase. (491 aa)
CCL27C-C motif chemokine ligand 27. (112 aa)
LOC104668961SCY domain-containing protein. (114 aa)
FOXO3Forkhead box O3. (617 aa)
SHC4SHC adaptor protein 4. (630 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCL19C-C motif chemokine. (98 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
PARD3Par-3 family cell polarity regulator. (1325 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
GNG13G protein subunit gamma 13. (67 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RAP1BUncharacterized protein. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
CCL17C-C motif chemokine. (91 aa)
CCL8C-C motif chemokine. (99 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
CCL14C-C motif chemokine. (99 aa)
CCL16C-C motif chemokine. (119 aa)
GNB1G protein subunit beta 1. (340 aa)
CXCL16C-X-C motif chemokine ligand 16. (275 aa)
RHOARas homolog family member A. (193 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
SHC1SHC adaptor protein 1. (574 aa)
PF4C-X-C motif chemokine. (101 aa)
LOC104658882C-X-C motif chemokine. (107 aa)
CCL20C-C motif chemokine. (96 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (726 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CCL4C-C motif chemokine. (92 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
LOC104654808C-X-C motif chemokine. (111 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
GNAI1G protein subunit alpha i1. (253 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
SRCTyrosine-protein kinase. (540 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CXCL6C-X-C motif chemokine. (123 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
VAV3Uncharacterized protein. (287 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
CCL26C-C motif chemokine. (94 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1659 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
LOC104664497C-C motif chemokine. (71 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CCL1C-C motif chemokine. (96 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
ITKTyrosine-protein kinase. (620 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CCL28C-C motif chemokine. (127 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ARRB1Arrestin beta 1. (473 aa)
LOC104668962SCY domain-containing protein. (114 aa)
PPBPC-X-C motif chemokine. (128 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CCL23C-C motif chemokine. (120 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ARRB2Arrestin beta 2. (453 aa)
GNB5G protein subunit beta 5. (403 aa)
PF4V1C-X-C motif chemokine. (101 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CXCL11C-X-C motif chemokine. (94 aa)
FGRTyrosine-protein kinase. (529 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
CDC42Uncharacterized protein. (191 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (359 aa)
WASWASP actin nucleation promoting factor. (500 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNB4G protein subunit beta 4. (340 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
LOC104678227C-C motif chemokine. (109 aa)
CCL13C-C motif chemokine. (98 aa)
RAF1Uncharacterized protein. (668 aa)
CCL18C-C motif chemokine. (88 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CXCL13C-X-C motif chemokine. (109 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAC2Rac family small GTPase 2. (192 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
HCKTyrosine-protein kinase. (591 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC104654807C-X-C motif chemokine. (107 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CCL22C-C motif chemokine. (93 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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