STRINGSTRING
RAB39B RAB39B WDR41 WDR41 GABARAP GABARAP HIF1A HIF1A RRAGA RRAGA ATG9A ATG9A RRAGC RRAGC LOC104654245 LOC104654245 RUBCN RUBCN AKT1 AKT1 ATG3 ATG3 PDPK1 PDPK1 LOC104657121 LOC104657121 LOC104654149 LOC104654149 ATG4C ATG4C RAB7B RAB7B ERN1 ERN1 MAPK8 MAPK8 RRAS RRAS MTMR4 MTMR4 PRKACB PRKACB STK11 STK11 EIF2AK4 EIF2AK4 SNAP29 SNAP29 ATG16L2 ATG16L2 WIPI1 WIPI1 ATG2A ATG2A ATG2B ATG2B DDIT4 DDIT4 ATG16L1 ATG16L1 MAPK9 MAPK9 MRAS MRAS DAPK2 DAPK2 MTMR3 MTMR3 RAB8A RAB8A PRKACA PRKACA EIF2S1 EIF2S1 PIK3CA PIK3CA PRKCD PRKCD PIK3CD PIK3CD STX17 STX17 ATG13 ATG13 PTEN PTEN MAP2K2 MAP2K2 MAP3K7 MAP3K7 NRBF2 NRBF2 MLST8 MLST8 RAB7A RAB7A LOC104668161 LOC104668161 CTSB CTSB NRAS NRAS ATG14 ATG14 IGF1R IGF1R LAMP2 LAMP2 RAB33B RAB33B ATG101 ATG101 BAD BAD PRAP1 PRAP1 MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 AMBRA1 AMBRA1 BNIP3 BNIP3 CTSD CTSD PRKCQ PRKCQ ENSRROP00000024190 ENSRROP00000024190 SQSTM1 SQSTM1 MAPK1 MAPK1 PPP2CA PPP2CA MTOR MTOR GABARAPL1 GABARAPL1 C9orf72 C9orf72 IRS4 IRS4 RB1CC1 RB1CC1 BCL2L1 BCL2L1 RPTOR RPTOR BECN1 BECN1 ZFYVE1 ZFYVE1 ATG10 ATG10 MAPK10 MAPK10 CTSL CTSL PRKAA1 PRKAA1 PIK3R4 PIK3R4 VAMP8 VAMP8 UVRAG UVRAG SMCR8 SMCR8 EIF2AK3 EIF2AK3 PIK3R3 PIK3R3 AKT1S1 AKT1S1 PIK3C3 PIK3C3 MAPK3 MAPK3 KRAS KRAS PRKAA2 PRKAA2 LAMP1 LAMP1 TP53INP2 TP53INP2 TSC1 TSC1 INS INS ATG7 ATG7 RPS6KB1 RPS6KB1 BCL2 BCL2 HRAS HRAS SUPT20H SUPT20H MTMR14 MTMR14 IGBP1 IGBP1 ATG4D ATG4D RHEB RHEB RAF1 RAF1 TANK TANK ATG5 ATG5 LOC104658843 LOC104658843 TRAF6 TRAF6 ATG4A ATG4A DAPK1 DAPK1 TBK1 TBK1 ATG9B ATG9B TSC2 TSC2 AKT2 AKT2 RRAS2 RRAS2 GABARAPL2 GABARAPL2 ATG12 ATG12 RPS6KB2 RPS6KB2 CFLAR CFLAR PIK3CB PIK3CB ITPR1 ITPR1 CAMKK2 CAMKK2 DAPK3 DAPK3 VMP1 VMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB39BRAB39B, member RAS oncogene family. (213 aa)
WDR41WD repeat domain 41. (459 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RRAGARas related GTP binding A. (313 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
RRAGCRas related GTP binding C. (399 aa)
LOC104654245Uncharacterized protein. (243 aa)
RUBCNRubicon autophagy regulator. (996 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ATG3Autophagy-related protein 3. (314 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
LOC104657121Uncharacterized protein. (339 aa)
LOC104654149Uncharacterized protein. (909 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (980 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RRASRAS related. (218 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
ATG16L2Autophagy related 16 like 2. (619 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ATG2AAutophagy related 2A. (1936 aa)
ATG2BAutophagy related 2B. (2078 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
MTMR3Myotubularin related protein 3. (1211 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (295 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
NRBF2Nuclear receptor binding factor 2. (289 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
LOC104668161Uncharacterized protein. (165 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ATG14Autophagy related 14. (492 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
ATG101Autophagy related 101. (218 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PRAP1Uncharacterized protein. (154 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (594 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (710 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
SQSTM1Sequestosome 1. (451 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
IRS4Insulin receptor substrate 4. (1227 aa)
RB1CC1RB1 inducible coiled-coil 1. (1576 aa)
BCL2L1BCL2 like 1. (233 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
BECN1Beclin 1. (450 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (789 aa)
ATG10Autophagy related 10. (220 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (341 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
UVRAGUV radiation resistance associated. (698 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
LAMP1Lysosomal associated membrane protein 1. (412 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
TSC1TSC complex subunit 1. (1163 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SUPT20HSPT20 homolog, SAGA complex component. (858 aa)
MTMR14Myotubularin related protein 14. (650 aa)
IGBP1Uncharacterized protein. (339 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (497 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RAF1Uncharacterized protein. (668 aa)
TANKTRAF family member associated NFKB activator. (457 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LOC104658843Uncharacterized protein. (359 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
TBK1TANK binding kinase 1. (729 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RRAS2RAS related 2. (176 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
VMP1Vacuole membrane protein 1. (406 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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