STRINGSTRING
GSK3B GSK3B FNIP1 FNIP1 RRAGA RRAGA RRAGC RRAGC ATP6V1A ATP6V1A WNT1 WNT1 AKT1 AKT1 FZD4 FZD4 BRAF BRAF SLC38A9 SLC38A9 PDPK1 PDPK1 FZD5 FZD5 ATP6V1G2 ATP6V1G2 CAB39L CAB39L PRR5 PRR5 RNF152 RNF152 FNIP2 FNIP2 ATP6V1E2 ATP6V1E2 WNT6 WNT6 CASTOR2 CASTOR2 WNT2 WNT2 TNF TNF STK11 STK11 DDIT4 DDIT4 RPS6KA6 RPS6KA6 TELO2 TELO2 TNFRSF1A TNFRSF1A PIK3CA PIK3CA WNT8A WNT8A PIK3CD PIK3CD WNT11 WNT11 SOS1 SOS1 WNT9A WNT9A PTEN PTEN CAB39 CAB39 MAP2K2 MAP2K2 WNT10A WNT10A RHOA RHOA WNT5A WNT5A LAMTOR3 LAMTOR3 MLST8 MLST8 WNT16 WNT16 RPS6KA2 RPS6KA2 LOC104668161 LOC104668161 PRKCG PRKCG WNT9B WNT9B WNT2B WNT2B NRAS NRAS EIF4B EIF4B FLCN FLCN MIOS MIOS IGF1R IGF1R FZD6 FZD6 DVL2 DVL2 EIF4E EIF4E LPIN2 LPIN2 DVL3 DVL3 PRKCB PRKCB MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 WNT8B WNT8B FZD9 FZD9 CLIP1 CLIP1 STRADB STRADB RPS6KA3 RPS6KA3 ENSRROP00000024190 ENSRROP00000024190 FZD7 FZD7 WNT4 WNT4 FZD2 FZD2 ATP6V1C1 ATP6V1C1 MAPK1 MAPK1 IKBKB IKBKB LRP5 LRP5 MTOR MTOR IGF1 IGF1 RPS6 RPS6 SOS2 SOS2 RICTOR RICTOR RPTOR RPTOR WNT3A WNT3A SLC7A5 SLC7A5 SEH1L SEH1L WNT3 WNT3 PRKAA1 PRKAA1 SLC3A2 SLC3A2 PIK3R3 PIK3R3 INSR INSR ATP6V1C2 ATP6V1C2 SGK1 SGK1 AKT1S1 AKT1S1 RPS6KA1 RPS6KA1 NPRL3 NPRL3 MAPK3 MAPK3 GRB10 GRB10 ATP6V1D ATP6V1D ATP6V1H ATP6V1H ATP6V1B1 ATP6V1B1 TBC1D7 TBC1D7 KRAS KRAS NPRL2 NPRL2 PRKAA2 PRKAA2 SKP2 SKP2 TSC1 TSC1 GRB2 GRB2 FZD10 FZD10 LPIN1 LPIN1 INS INS SEC13 SEC13 RPS6KB1 RPS6KB1 HRAS HRAS RHEB RHEB RAF1 RAF1 EIF4E1B EIF4E1B CHUK CHUK FZD3 FZD3 LRP6 LRP6 TTI1 TTI1 WDR59 WDR59 TSC2 TSC2 AKT2 AKT2 EIF4E2 EIF4E2 ATP6V1B2 ATP6V1B2 CASTOR1 CASTOR1 LAMTOR1 LAMTOR1 PRKCA PRKCA LAMTOR5 LAMTOR5 WNT7A WNT7A WNT7B WNT7B RPS6KB2 RPS6KB2 PIK3CB PIK3CB WNT10B WNT10B ATP6V1G1 ATP6V1G1 LAMTOR2 LAMTOR2 LAMTOR4 LAMTOR4 WNT5B WNT5B EIF4EBP1 EIF4EBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
FNIP1Folliculin interacting protein 1. (1039 aa)
RRAGARas related GTP binding A. (313 aa)
RRAGCRas related GTP binding C. (399 aa)
ATP6V1AUncharacterized protein. (617 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
PRR5Proline rich 5. (410 aa)
RNF152Ring finger protein 152. (203 aa)
FNIP2Folliculin interacting protein 2. (1171 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
CASTOR2Uncharacterized protein. (329 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
RPS6KA6Ribosomal protein S6 kinase. (732 aa)
TELO2Telomere maintenance 2. (837 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CAB39Calcium binding protein 39. (341 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RHOARas homolog family member A. (193 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RPS6KA2Protein kinase domain-containing protein. (200 aa)
LOC104668161Uncharacterized protein. (165 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
EIF4BEukaryotic translation initiation factor 4B. (616 aa)
FLCNFolliculin. (579 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
LPIN2Lipin 2. (933 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1438 aa)
STRADBSTE20 related adaptor beta. (418 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1695 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SLC7A5Solute carrier family 7 member 5. (500 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (431 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
SLC3A2Solute carrier family 3 member 2. (629 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
AKT1S1AKT1 substrate 1. (276 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
ATP6V1DUncharacterized protein. (247 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (391 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
TSC1TSC complex subunit 1. (1163 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
LPIN1Lipin 1. (945 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (331 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RAF1Uncharacterized protein. (668 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
WDR59WD repeat domain 59. (993 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (538 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (342 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LAMTOR5Uncharacterized protein. (169 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (135 aa)
LAMTOR4Uncharacterized protein. (99 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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