STRINGSTRING
PFKFB4 PFKFB4 PCK2 PCK2 AKT1 AKT1 PPARGC1A PPARGC1A PDPK1 PDPK1 CAB39L CAB39L PRKAB2 PRKAB2 G6PC G6PC EEF2 EEF2 ADIPOR2 ADIPOR2 G6PC3 G6PC3 STK11 STK11 PPP2R5E PPP2R5E CD36 CD36 TBC1D1 TBC1D1 SLC2A4 SLC2A4 PPP2R5A PPP2R5A CFTR CFTR PPP2R2D PPP2R2D FOXO3 FOXO3 RAB10 RAB10 CPT1C CPT1C RAB8A RAB8A PRKAG2 PRKAG2 CPT1B CPT1B PIK3CA PIK3CA HNF4A HNF4A PIK3CD PIK3CD ADIPOQ ADIPOQ RAB2A RAB2A CAB39 CAB39 LIPE LIPE PRKAG3 PRKAG3 MAP3K7 MAP3K7 ADIPOR1 ADIPOR1 CCND1 CCND1 CREB5 CREB5 LEP LEP PPP2R1B PPP2R1B IGF1R IGF1R ACACA ACACA PFKP PFKP LEPR LEPR EEF2K EEF2K SIRT1 SIRT1 AKT3 AKT3 GYS1 GYS1 PIK3R1 PIK3R1 STRADB STRADB G6PC2 G6PC2 CREB3 CREB3 CREB1 CREB1 CCNA1 CCNA1 PFKM PFKM ENSRROP00000024190 ENSRROP00000024190 CCNA2 CCNA2 PPP2CA PPP2CA MTOR MTOR IGF1 IGF1 PFKFB3 PFKFB3 IRS4 IRS4 RPTOR RPTOR PRKAG1 PRKAG1 PFKFB2 PFKFB2 ELAVL1 ELAVL1 SCD5 SCD5 RAB14 RAB14 FBP1 FBP1 PRKAA1 PRKAA1 SREBF1 SREBF1 CRTC2 CRTC2 PPP2R1A PPP2R1A PIK3R3 PIK3R3 INSR INSR AKT1S1 AKT1S1 MLYCD MLYCD PPP2R3C PPP2R3C HMGCR HMGCR SCD SCD PCK1 PCK1 FBP2 FBP2 PPP2R2B PPP2R2B PRKAA2 PRKAA2 ACACB ACACB TSC1 TSC1 INS INS RPS6KB1 RPS6KB1 ADRA1A ADRA1A PRKAB1 PRKAB1 PPP2R5D PPP2R5D PPP2R2A PPP2R2A CREB3L1 CREB3L1 FOXO1 FOXO1 RHEB RHEB PPP2R5B PPP2R5B CPT1A CPT1A PPP2R5C PPP2R5C PPP2R3A PPP2R3A FASN FASN TSC2 TSC2 AKT2 AKT2 RPS6KB2 RPS6KB2 PPARG PPARG PIK3CB PIK3CB CAMKK2 CAMKK2 CREB3L2 CREB3L2 PPP2R2C PPP2R2C EIF4EBP1 EIF4EBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (462 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
EEF2Eukaryotic translation elongation factor 2. (861 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TBC1D1TBC1 domain family member 1. (1263 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
FOXO3Forkhead box O3. (617 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
RAB2ARAB2A, member RAS oncogene family. (212 aa)
CAB39Calcium binding protein 39. (341 aa)
LIPELipase E, hormone sensitive type. (1054 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (746 aa)
LEPRLeptin receptor. (1163 aa)
EEF2KEukaryotic elongation factor 2 kinase. (721 aa)
SIRT1Sirtuin 1. (746 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STRADBSTE20 related adaptor beta. (418 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (568 aa)
IRS4Insulin receptor substrate 4. (1227 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (409 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
CRTC2CREB regulated transcription coactivator 2. (699 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
AKT1S1AKT1 substrate 1. (276 aa)
MLYCDMalonyl-CoA decarboxylase. (463 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
SCDUncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (359 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
ACACBAcetyl-CoA carboxylase beta. (2442 aa)
TSC1TSC complex subunit 1. (1163 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
FOXO1Forkhead box O1. (585 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (596 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
FASNFatty acid synthase. (2504 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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