STRINGSTRING
IGFBP3 IGFBP3 CAPN2 CAPN2 HIPK4 HIPK4 TGFB3 TGFB3 IL6 IL6 LIN37 LIN37 AKT1 AKT1 HIPK1 HIPK1 TGFBR2 TGFBR2 E2F3 E2F3 ETS1 ETS1 RELA RELA IL1A IL1A RRAS RRAS NFATC4 NFATC4 CALML3 CALML3 VDAC1 VDAC1 FOXO3 FOXO3 NFATC1 NFATC1 RAD1 RAD1 SERPINE1 SERPINE1 MRAS MRAS RAD9B RAD9B HIPK2 HIPK2 E2F2 E2F2 CDK4 CDK4 CDK6 CDK6 PIK3CA PIK3CA MAP2K6 MAP2K6 BTRC BTRC PIK3CD PIK3CD TRAF3IP2 TRAF3IP2 CCNB2 CCNB2 PPP3R1 PPP3R1 MYBL2 MYBL2 PTEN PTEN MAP2K2 MAP2K2 TRPM7 TRPM7 CCNE1 CCNE1 PPP3CB PPP3CB MYC MYC LOC104676775 LOC104676775 GADD45A GADD45A CCND1 CCND1 CCNE2 CCNE2 NRAS NRAS CALM3 CALM3 E2F5 E2F5 ENSRROP00000019822 ENSRROP00000019822 MAP2K1 MAP2K1 SIRT1 SIRT1 NFATC3 NFATC3 AKT3 AKT3 PIK3R1 PIK3R1 CCND2 CCND2 HUS1 HUS1 RBBP4 RBBP4 SLC25A4 SLC25A4 CCNA1 CCNA1 ITPR2 ITPR2 RB1 RB1 CACNA1D CACNA1D E2F4 E2F4 CCNA2 CCNA2 TGFBR1 TGFBR1 SQSTM1 SQSTM1 MAPK1 MAPK1 VDAC2 VDAC2 MAP2K3 MAP2K3 MTOR MTOR MAPK14 MAPK14 LOC104676771 LOC104676771 PPP3CC PPP3CC TP53 TP53 CDKN2A CDKN2A PPP1CB PPP1CB NBN NBN CDKN1A CDKN1A LOC104661254 LOC104661254 CDKN2B CDKN2B TRPV4 TRPV4 SLC25A6 SLC25A6 MAPKAPK2 MAPKAPK2 FOXM1 FOXM1 RAD50 RAD50 LIN52 LIN52 KIR2DL4 KIR2DL4 GADD45G GADD45G PIK3R3 PIK3R3 E2F1 E2F1 ATM ATM MAPK3 MAPK3 RASSF5 RASSF5 LOC104662055 LOC104662055 PPP1CA PPP1CA TGFB2 TGFB2 KRAS KRAS LIN9 LIN9 PPID PPID TSC1 TSC1 ZFP36L1 ZFP36L1 MRE11 MRE11 CCND3 CCND3 HRAS HRAS ITPR3 ITPR3 FOXO1 FOXO1 GADD45B GADD45B CAPN1 CAPN1 RHEB RHEB RAF1 RAF1 ZFP36L2 ZFP36L2 LIN54 LIN54 RBL1 RBL1 HLA-E HLA-E HIPK3 HIPK3 NFATC2 NFATC2 TGFB1 TGFB1 CDK1 CDK1 CDC25A CDC25A TSC2 TSC2 AKT2 AKT2 PPP1CC PPP1CC VDAC3 VDAC3 CALML6 CALML6 RRAS2 RRAS2 MCU MCU CCNB1 CCNB1 PIK3CB PIK3CB RBL2 RBL2 ITPR1 ITPR1 CXCL8 CXCL8 CALML4 CALML4 NFKB1 NFKB1 PPP3CA PPP3CA EIF4EBP1 EIF4EBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (597 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
E2F3E2F transcription factor 3. (465 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
RRASRAS related. (218 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
FOXO3Forkhead box O3. (617 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
RAD1Uncharacterized protein. (280 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
HIPK2Homeodomain interacting protein kinase 2. (1197 aa)
E2F2E2F transcription factor 2. (437 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
PPP3R1Uncharacterized protein. (189 aa)
MYBL2Uncharacterized protein. (868 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
E2F5E2F transcription factor 5. (345 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SIRT1Sirtuin 1. (746 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
RB1RB transcriptional corepressor 1. (929 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
E2F4E2F transcription factor 4. (431 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SQSTM1Sequestosome 1. (451 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC104661254Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
FOXM1Forkhead box M1. (771 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
KIR2DL4Uncharacterized protein. (237 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F1E2F transcription factor 1. (485 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RASSF5Ras association domain family member 5. (391 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LIN9Lin-9 DREAM MuvB core complex component. (613 aa)
PPIDUncharacterized protein. (373 aa)
TSC1TSC complex subunit 1. (1163 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
FOXO1Forkhead box O1. (585 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (714 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RAF1Uncharacterized protein. (668 aa)
ZFP36L2ZFP36 ring finger protein like 2. (497 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
RBL1RB transcriptional corepressor like 1. (1033 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CDC25ACell division cycle 25A. (524 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
VDAC3Uncharacterized protein. (284 aa)
CALML6Calmodulin like 6. (181 aa)
RRAS2RAS related 2. (176 aa)
MCUMitochondrial calcium uniporter. (351 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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