STRINGSTRING
LOC104677263 LOC104677263 CREBBP CREBBP ID2 ID2 TGFB3 TGFB3 TGIF2 TGIF2 BMP7 BMP7 TGFBR2 TGFBR2 GREM2 GREM2 SMURF2 SMURF2 ACVR2A ACVR2A GDF5 GDF5 NOG NOG TNF TNF ACVR1 ACVR1 ID3 ID3 RBX1 RBX1 SP1 SP1 CUL1 CUL1 BMP2 BMP2 ACVR1C ACVR1C NEO1 NEO1 TFDP1 TFDP1 INHBB INHBB RHOA RHOA GDF7 GDF7 MYC MYC BMP6 BMP6 IFNG IFNG ID1 ID1 INHBE INHBE DCN DCN PPP2R1B PPP2R1B SMURF1 SMURF1 E2F5 E2F5 RGMA RGMA ACVR1B ACVR1B BMPR1B BMPR1B FMOD FMOD INHBA INHBA AMHR2 AMHR2 ZFYVE9 ZFYVE9 E2F4 E2F4 BMPR1A BMPR1A TGIF1 TGIF1 TGFBR1 TGFBR1 MAPK1 MAPK1 PPP2CA PPP2CA BMP8B BMP8B THSD4 THSD4 SMAD5 SMAD5 ACVR2B ACVR2B FBN1 FBN1 CDKN2B CDKN2B EP300 EP300 NODAL NODAL PPP2R1A PPP2R1A HJV HJV MAPK3 MAPK3 TGFB2 TGFB2 RGMB RGMB RPS6KB1 RPS6KB1 INHBC INHBC BMP4 BMP4 LTBP1 LTBP1 PITX2 PITX2 SMAD1 SMAD1 RBL1 RBL1 SMAD6 SMAD6 TGFB1 TGFB1 SMAD7 SMAD7 ROCK1 ROCK1 SKP1 SKP1 HAMP HAMP THBS1 THBS1 RPS6KB2 RPS6KB2 SMAD4 SMAD4 NBL1 NBL1 BMP5 BMP5 FST FST BAMBI BAMBI LOC104673417 LOC104673417 CHRD CHRD ZFYVE16 ZFYVE16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC104677263Uncharacterized protein; Belongs to the SKP1 family. (155 aa)
CREBBPCREB binding protein. (2442 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GREM2Gremlin. (168 aa)
SMURF2E3 ubiquitin-protein ligase. (741 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF5Growth differentiation factor 5. (499 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
RBX1Ring-box 1. (108 aa)
SP1Sp1 transcription factor. (786 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (396 aa)
NEO1Neogenin 1. (1461 aa)
TFDP1Transcription factor. (410 aa)
INHBBInhibin subunit beta B. (396 aa)
RHOARas homolog family member A. (193 aa)
GDF7Growth differentiation factor 7. (450 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
BMP6Bone morphogenetic protein 6. (439 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
INHBEInhibin subunit beta E. (351 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
SMURF1E3 ubiquitin-protein ligase. (764 aa)
E2F5E2F transcription factor 5. (345 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FMODFibromodulin. (376 aa)
INHBAInhibin subunit beta A. (492 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
E2F4E2F transcription factor 4. (431 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGIF1TGFB induced factor homeobox 1. (335 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
THSD4Thrombospondin type 1 domain containing 4. (658 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
FBN1Fibrillin 1. (2871 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
EP300E1A binding protein p300. (2413 aa)
NODALNodal growth differentiation factor. (347 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (478 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
INHBCInhibin subunit beta C. (352 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1691 aa)
PITX2Homeobox protein. (325 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RBL1RB transcriptional corepressor like 1. (1033 aa)
SMAD6MH2 domain-containing protein. (226 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SMAD7MH2 domain-containing protein. (211 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
THBS1Thrombospondin 1. (1170 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NBL1NBL1, DAN family BMP antagonist. (216 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
FSTFollistatin. (350 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC104673417Homeobox domain-containing protein. (272 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1537 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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