STRINGSTRING
ADCY8 ADCY8 GABARAP GABARAP MEF2D MEF2D AKT1 AKT1 GNGT1 GNGT1 MYLK MYLK PPARGC1A PPARGC1A NOS2 NOS2 CAMK4 CAMK4 ADCY5 ADCY5 PRKAB2 PRKAB2 RRAS RRAS CALML3 CALML3 PRKACB PRKACB GNB3 GNB3 LOC104670765 LOC104670765 GNA13 GNA13 APLNR APLNR SLC8A3 SLC8A3 SLC8A1 SLC8A1 SERPINE1 SERPINE1 GNG7 GNG7 PRKCE PRKCE ADCY1 ADCY1 GNAI2 GNAI2 HDAC5 HDAC5 MRAS MRAS PIK3R6 PIK3R6 PRKAG2 PRKAG2 GNG13 GNG13 PRKACA PRKACA NOS1 NOS1 ADCY2 ADCY2 NRF1 NRF1 PDE3B PDE3B JAG1 JAG1 AGTR1 AGTR1 LIPE LIPE MAP2K2 MAP2K2 PRKAG3 PRKAG3 SPHK1 SPHK1 GNB1 GNB1 UCP1 UCP1 PIK3CG PIK3CG MYL2 MYL2 MYL4 MYL4 CCND1 CCND1 GNAI3 GNAI3 PLIN1 PLIN1 NRAS NRAS LOC104665620 LOC104665620 CALM3 CALM3 GNAI1 GNAI1 MEF2B MEF2B PLCB3 PLCB3 ENSRROP00000019822 ENSRROP00000019822 MAP2K1 MAP2K1 NOS3 NOS3 AKT3 AKT3 PLCB1 PLCB1 SLC9A1 SLC9A1 ITPR2 ITPR2 SPHK2 SPHK2 HDAC4 HDAC4 TGFBR1 TGFBR1 MAPK1 MAPK1 PLAT PLAT MTOR MTOR GABARAPL1 GABARAPL1 RPS6 RPS6 PLCB4 PLCB4 ADCY9 ADCY9 GNG3 GNG3 KLF2 KLF2 BECN1 BECN1 PRKAG1 PRKAG1 MYLK4 MYLK4 SPP1 SPP1 RYR1 RYR1 PRKAA1 PRKAA1 PIK3R4 PIK3R4 RYR3 RYR3 GNB5 GNB5 PIK3C3 PIK3C3 ADCY10 ADCY10 MAPK3 MAPK3 LOC104662055 LOC104662055 GNG4 GNG4 KRAS KRAS PRKAA2 PRKAA2 RPS6KB1 RPS6KB1 GNG5 GNG5 GNAQ GNAQ HRAS HRAS ITPR3 ITPR3 RYR2 RYR2 GNB4 GNB4 PRKAB1 PRKAB1 ADCY7 ADCY7 MYLK2 MYLK2 CDH1 CDH1 RAF1 RAF1 GNG11 GNG11 AKT2 AKT2 GNB2 GNB2 ADCY6 ADCY6 ADCY3 ADCY3 CALML6 CALML6 RRAS2 RRAS2 GABARAPL2 GABARAPL2 NOTCH3 NOTCH3 GNG12 GNG12 PIK3R5 PIK3R5 EGR1 EGR1 RPS6KB2 RPS6KB2 MYLK3 MYLK3 SMAD4 SMAD4 APLN APLN ITPR1 ITPR1 GNG8 GNG8 CALML4 CALML4 SLC8A2 SLC8A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
MYLKMyosin light chain kinase. (1911 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (274 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
RRASRAS related. (218 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB3G protein subunit beta 3. (340 aa)
LOC104670765Uncharacterized protein. (248 aa)
GNA13G protein subunit alpha 13. (308 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
GNAI2G protein subunit alpha i2. (355 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
GNG13G protein subunit gamma 13. (67 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1184 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
PDE3BPhosphodiesterase. (1113 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
LIPELipase E, hormone sensitive type. (1054 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
SPHK1Sphingosine kinase 1. (472 aa)
GNB1G protein subunit beta 1. (340 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
MYL2Myosin light chain 2. (166 aa)
MYL4Myosin light chain 4. (195 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC104665620Uncharacterized protein. (248 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNAI1G protein subunit alpha i1. (253 aa)
MEF2BMyocyte enhancer factor 2B. (368 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
SPHK2Sphingosine kinase 2. (665 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KLF2Uncharacterized protein. (115 aa)
BECN1Beclin 1. (450 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
RYR1Ryanodine receptor 1. (4931 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
RYR3Ryanodine receptor 3. (4851 aa)
GNB5G protein subunit beta 5. (403 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
ADCY10Adenylate cyclase 10. (1517 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (359 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
RYR2Ryanodine receptor 2. (4938 aa)
GNB4G protein subunit beta 4. (340 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
RAF1Uncharacterized protein. (668 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
CALML6Calmodulin like 6. (181 aa)
RRAS2RAS related 2. (176 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
NOTCH3Notch receptor 3. (2336 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
APLNApelin. (77 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CALML4Calmodulin like 4. (192 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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