STRINGSTRING
IFNB1 IFNB1 SOCS1 SOCS1 CYLD CYLD AKT1 AKT1 IKBKG IKBKG CSF1R CSF1R MAP2K7 MAP2K7 CAMK4 CAMK4 TGFBR2 TGFBR2 FOSB FOSB RELA RELA IL1A IL1A TNFRSF11B TNFRSF11B MAPK8 MAPK8 TNF TNF SOCS3 SOCS3 JUNB JUNB MAPK9 MAPK9 TNFSF11 TNFSF11 NFATC1 NFATC1 TAB2 TAB2 TNFRSF1A TNFRSF1A IRF9 IRF9 IL1R1 IL1R1 PIK3CA PIK3CA MAP2K6 MAP2K6 BLNK BLNK MITF MITF PIK3CD PIK3CD TYK2 TYK2 LCK LCK STAT2 STAT2 RELB RELB PPP3R1 PPP3R1 LOC104675310 LOC104675310 MAP3K7 MAP3K7 TAB1 TAB1 PPP3CB PPP3CB TREM2 TREM2 LOC104675312 LOC104675312 IFNG IFNG TRAF2 TRAF2 TNFRSF11A TNFRSF11A FYN FYN IFNAR2 IFNAR2 IFNAR1 IFNAR1 BTK BTK SYK SYK ACP5 ACP5 NFKB2 NFKB2 TEC TEC MAP2K1 MAP2K1 SIRPB1 SIRPB1 AKT3 AKT3 OSCAR OSCAR MAP3K14 MAP3K14 PIK3R1 PIK3R1 IFNGR2 IFNGR2 CSF1 CSF1 IFNGR1 IFNGR1 CREB1 CREB1 ITGB3 ITGB3 TGFBR1 TGFBR1 CTSK CTSK SQSTM1 SQSTM1 MAPK1 MAPK1 IKBKB IKBKB NOX1 NOX1 MAPK14 MAPK14 NCF1 NCF1 NFKBIA NFKBIA LCP2 LCP2 PPP3CC PPP3CC FCGR2B FCGR2B GAB2 GAB2 SIRPA SIRPA MAPK10 MAPK10 FOS FOS PIK3R3 PIK3R3 MAPK3 MAPK3 LILRA1 LILRA1 FOSL2 FOSL2 TGFB2 TGFB2 NCF4 NCF4 LOC104670100 LOC104670100 STAT1 STAT1 GRB2 GRB2 IL1B IL1B CYBA CYBA CHUK CHUK LILRA4 LILRA4 TRAF6 TRAF6 NFATC2 NFATC2 TGFB1 TGFB1 JAK1 JAK1 AKT2 AKT2 FHL2 FHL2 NCF2 NCF2 CALCR CALCR FOSL1 FOSL1 SIRPG SIRPG PPARG PPARG PIK3CB PIK3CB PLCG2 PLCG2 NFKB1 NFKB1 SPI1 SPI1 PPP3CA PPP3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNB1Interferon beta 1. (187 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (654 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (274 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
TNFRSF11BTNF receptor superfamily member 11b. (407 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IRF9Interferon regulatory factor 9. (392 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BLNKB cell linker. (456 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
LCKTyrosine-protein kinase. (561 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
RELBRELB proto-oncogene, NF-kB subunit. (541 aa)
PPP3R1Uncharacterized protein. (189 aa)
LOC104675310Uncharacterized protein. (484 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC104675312Uncharacterized protein. (420 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
TNFRSF11ATNF receptor superfamily member 11a. (595 aa)
FYNTyrosine-protein kinase. (537 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
BTKTyrosine-protein kinase. (690 aa)
SYKTyrosine-protein kinase. (635 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
TECTyrosine-protein kinase. (630 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SIRPB1Uncharacterized protein. (397 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
OSCAROsteoclast associated Ig-like receptor. (269 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
SQSTM1Sequestosome 1. (451 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
NOX1NADPH oxidase 1. (564 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
FCGR2BUncharacterized protein. (313 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
SIRPAUncharacterized protein. (507 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LILRA1Uncharacterized protein. (492 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
LOC104670100Uncharacterized protein. (351 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (499 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FHL2Four and a half LIM domains 2. (389 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (489 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SIRPGSignal regulatory protein gamma. (354 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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