STRINGSTRING
GSK3B GSK3B CTNNA1 CTNNA1 STK3 STK3 ID2 ID2 TGFB3 TGFB3 WNT1 WNT1 MOB1B MOB1B BMP7 BMP7 FZD4 FZD4 SOX2 SOX2 PATJ PATJ FZD5 FZD5 TGFBR2 TGFBR2 FRMD6 FRMD6 WNT6 WNT6 NF2 NF2 WNT2 WNT2 GDF5 GDF5 PARD6A PARD6A CTNNA2 CTNNA2 WWTR1 WWTR1 PPP2R2D PPP2R2D RASSF6 RASSF6 ACTB ACTB SERPINE1 SERPINE1 ACTG1 ACTG1 DLG5 DLG5 TCF7L1 TCF7L1 PARD3 PARD3 BMP2 BMP2 LOC104662475 LOC104662475 WNT8A WNT8A BTRC BTRC DLG1 DLG1 AXIN2 AXIN2 WNT11 WNT11 SCRIB SCRIB WNT9A WNT9A WNT10A WNT10A TP53BP2 TP53BP2 YWHAB YWHAB WNT5A WNT5A LLGL1 LLGL1 MPP5 MPP5 LOC104662560 LOC104662560 GDF7 GDF7 SNAI2 SNAI2 WNT16 WNT16 MYC MYC BMP6 BMP6 NKD1 NKD1 CCND1 CCND1 YWHAZ YWHAZ WNT9B WNT9B WNT2B WNT2B ID1 ID1 PPP2R1B PPP2R1B FZD6 FZD6 FGF1 FGF1 DVL2 DVL2 YAP1 YAP1 DVL3 DVL3 BMPR1B BMPR1B APC2 APC2 WNT8B WNT8B YWHAG YWHAG FZD9 FZD9 LATS2 LATS2 CCND2 CCND2 LATS1 LATS1 BMPR1A BMPR1A FZD7 FZD7 WNT4 WNT4 FZD2 FZD2 TGFBR1 TGFBR1 PPP2CA PPP2CA BMP8B BMP8B AXIN1 AXIN1 AFP AFP PPP1CB PPP1CB WNT3A WNT3A TEAD1 TEAD1 WNT3 WNT3 MOB1A MOB1A CTNNB1 CTNNB1 PRKCI PRKCI PPP2R1A PPP2R1A WWC1 WWC1 YWHAE YWHAE SAV1 SAV1 TEAD2 TEAD2 BIRC2 BIRC2 PPP1CA PPP1CA AMOT AMOT CSNK1E CSNK1E TGFB2 TGFB2 AJUBA AJUBA LEF1 LEF1 PPP2R2B PPP2R2B FZD10 FZD10 CCND3 CCND3 LIMD1 LIMD1 CRB1 CRB1 PPP2R2A PPP2R2A CSNK1D CSNK1D CDH1 CDH1 BMP4 BMP4 SMAD1 SMAD1 FZD3 FZD3 YWHAH YWHAH PRKCZ PRKCZ PARD6B PARD6B TGFB1 TGFB1 PARD6G PARD6G AREG AREG SMAD7 SMAD7 PPP1CC PPP1CC CRB2 CRB2 ITGB2 ITGB2 WNT7A WNT7A LLGL2 LLGL2 TP73 TP73 WNT7B WNT7B YWHAQ YWHAQ SMAD4 SMAD4 WNT10B WNT10B PPP2R2C PPP2R2C BMP5 BMP5 WNT5B WNT5B GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
CTNNA1Catenin alpha 1. (906 aa)
STK3Serine/threonine kinase 3. (519 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MOB1BMOB kinase activator 1B. (221 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SOX2SRY-box transcription factor 2. (319 aa)
PATJPATJ crumbs cell polarity complex component. (1883 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FRMD6FERM domain containing 6. (622 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
NF2Neurofibromin 2. (595 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
GDF5Growth differentiation factor 5. (499 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
CTNNA2Catenin alpha 2. (919 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
RASSF6Ras association domain family member 6. (337 aa)
ACTBActin beta. (375 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
ACTG1Actin gamma 1. (375 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
PARD3Par-3 family cell polarity regulator. (1325 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
LOC104662475Uncharacterized protein. (184 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
AXIN2Axin 2. (843 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1066 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LOC104662560Uncharacterized protein. (552 aa)
GDF7Growth differentiation factor 7. (450 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
BMP6Bone morphogenetic protein 6. (439 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (226 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
YAP1Yes associated protein 1. (508 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
LATS2Non-specific serine/threonine protein kinase. (1083 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
AXIN1Axin 1. (867 aa)
AFPAlpha fetoprotein. (576 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
MOB1AMOB kinase activator 1A. (216 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
WWC1WW and C2 domain containing 1. (1112 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
AMOTAngiomotin. (1086 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AJUBAAjuba LIM protein. (538 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
LIMD1LIM domains containing 1. (545 aa)
CRB1Crumbs cell polarity complex component 1. (1233 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CSNK1DCasein kinase 1 delta. (406 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
AREGAmphiregulin. (274 aa)
SMAD7MH2 domain-containing protein. (211 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
ITGB2Integrin beta. (769 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
GLI2GLI family zinc finger 2. (1586 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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