STRINGSTRING
GSK3B GSK3B VEGFB VEGFB COL9A2 COL9A2 LAMA4 LAMA4 ITGB8 ITGB8 CAPN2 CAPN2 ITGAV ITGAV PDGFB PDGFB AKT1 AKT1 MYLK MYLK COL4A3 COL4A3 BRAF BRAF MYL9 MYL9 VTN VTN PDPK1 PDPK1 DOCK1 DOCK1 PIP5K1A PIP5K1A ITGA4 ITGA4 CAV3 CAV3 LOC104654122 LOC104654122 MAPK8 MAPK8 COL2A1 COL2A1 TNC TNC PAK2 PAK2 LAMC1 LAMC1 MAPK9 MAPK9 FLNC FLNC COL4A1 COL4A1 SHC4 SHC4 ACTB ACTB HGF HGF ITGB7 ITGB7 PPP1R12A PPP1R12A ACTG1 ACTG1 PARVG PARVG VEGFC VEGFC VEGFD VEGFD COL9A3 COL9A3 THBS3 THBS3 RAP1B RAP1B PIK3CA PIK3CA PIK3CD PIK3CD ITGA1 ITGA1 VAV1 VAV1 SOS1 SOS1 VAV2 VAV2 PTEN PTEN COL4A4 COL4A4 LOC104656442 LOC104656442 LAMA1 LAMA1 RHOA RHOA BCAR1 BCAR1 SHC1 SHC1 COL6A5 COL6A5 PDGFA PDGFA PIP5K1C PIP5K1C ITGA11 ITGA11 MYL2 MYL2 CCND1 CCND1 PRKCG PRKCG LAMA3 LAMA3 ITGA9 ITGA9 FYN FYN IGF1R IGF1R LOC104658196 LOC104658196 SRC SRC COL6A3 COL6A3 BAD BAD TNR TNR COL6A1 COL6A1 PGF PGF PRKCB PRKCB PIP5K1B PIP5K1B MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 ITGB5 ITGB5 FN1 FN1 CAV2 CAV2 ROCK2 ROCK2 TLN1 TLN1 VAV3 VAV3 CCND2 CCND2 ITGB3 ITGB3 TLN2 TLN2 PDGFD PDGFD EGF EGF CRK CRK IBSP IBSP LAMA5 LAMA5 ARHGAP35 ARHGAP35 ENSRROP00000024190 ENSRROP00000024190 CAV1 CAV1 XIAP XIAP KDR KDR MAPK1 MAPK1 FLT4 FLT4 PARVA PARVA ITGA6 ITGA6 IGF1 IGF1 DIAPH1 DIAPH1 LAMB2 LAMB2 MYL5 MYL5 SOS2 SOS2 COL6A6 COL6A6 TNN TNN PPP1CB PPP1CB ACTN1 ACTN1 RELN RELN PDGFRA PDGFRA MYLK4 MYLK4 SPP1 SPP1 MAPK10 MAPK10 LOC104680681 LOC104680681 CHAD CHAD COL4A2 COL4A2 ITGA10 ITGA10 THBS2 THBS2 COL6A2 COL6A2 CTNNB1 CTNNB1 PIK3R3 PIK3R3 PPP1R12B PPP1R12B LAMB1 LAMB1 MAPK3 MAPK3 COL9A1 COL9A1 BIRC2 BIRC2 PPP1CA PPP1CA PARVB PARVB RASGRF1 RASGRF1 PTK2 PTK2 PAK4 PAK4 GRB2 GRB2 PDGFC PDGFC ELK1 ELK1 BCL2 BCL2 CDC42 CDC42 CCND3 CCND3 HRAS HRAS THBS4 THBS4 FLNA FLNA PAK6 PAK6 ZYX ZYX PAK5 PAK5 MYLK2 MYLK2 EGFR EGFR ITGA2B ITGA2B RAF1 RAF1 PDGFRB PDGFRB LAMB3 LAMB3 ITGA2 ITGA2 FLNB FLNB MET MET VWF VWF RAP1A RAP1A RAC2 RAC2 ARHGAP5 ARHGAP5 MYL12A MYL12A CRKL CRKL AKT2 AKT2 ROCK1 ROCK1 PPP1CC PPP1CC COMP COMP ITGA7 ITGA7 VEGFA VEGFA COL4A6 COL4A6 COL1A2 COL1A2 FLT1 FLT1 ITGA3 ITGA3 PRKCA PRKCA ITGA8 ITGA8 COL1A1 COL1A1 ITGB6 ITGB6 VASP VASP THBS1 THBS1 MYLK3 MYLK3 LAMC3 LAMC3 PIK3CB PIK3CB ITGB1 ITGB1 ACTN4 ACTN4 ERBB2 ERBB2 LAMB4 LAMB4 PAK1 PAK1 ITGA5 ITGA5 LAMC2 LAMC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (597 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYLKMyosin light chain kinase. (1911 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
MYL9Myosin light chain 9. (172 aa)
VTNSMB domain-containing protein. (478 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LOC104654122Myosin light chain 12B. (172 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
TNCTenascin C. (2201 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
FLNCFilamin C. (2674 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
SHC4SHC adaptor protein 4. (630 aa)
ACTBActin beta. (375 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (907 aa)
ACTG1Actin gamma 1. (375 aa)
PARVGParvin gamma. (331 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
COL9A3Uncharacterized protein. (684 aa)
THBS3Thrombospondin 3. (956 aa)
RAP1BUncharacterized protein. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
LOC104656442Uncharacterized protein. (2303 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
RHOARas homolog family member A. (193 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
SHC1SHC adaptor protein 1. (574 aa)
COL6A5Collagen type VI alpha 5 chain. (1745 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (700 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1191 aa)
MYL2Myosin light chain 2. (166 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (612 aa)
FYNTyrosine-protein kinase. (537 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC104658196CRIB domain-containing protein. (176 aa)
SRCTyrosine-protein kinase. (540 aa)
COL6A3Collagen type VI alpha 3 chain. (3175 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TNRTenascin R. (1358 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
FN1Fibronectin 1. (2479 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
TLN1Talin 1. (2562 aa)
VAV3Uncharacterized protein. (287 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TLN2Talin 2. (2544 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
PARVAParvin alpha. (372 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
DIAPH1Diaphanous related formin 1. (1238 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
MYL5Myosin light chain 5. (173 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
TNNTenascin N. (1299 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
ACTN1Actinin alpha 1. (930 aa)
RELNUncharacterized protein. (879 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
LOC104680681Uncharacterized protein. (525 aa)
CHADChondroadherin. (359 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1168 aa)
THBS2Thrombospondin 2. (1172 aa)
COL6A2Collagen type VI alpha 2 chain. (1019 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1058 aa)
LAMB1Laminin subunit beta 1. (1836 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
PARVBParvin beta. (397 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
PAK4Non-specific serine/threonine protein kinase. (655 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ELK1Uncharacterized protein. (428 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDC42Uncharacterized protein. (191 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
THBS4Thrombospondin 4. (961 aa)
FLNAFilamin A. (2647 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ZYXZyxin. (570 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
RAF1Uncharacterized protein. (668 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
FLNBFilamin B. (2636 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1405 aa)
VWFVon Willebrand factor. (2804 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
MYL12AUncharacterized protein. (206 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
THBS1Thrombospondin 1. (1170 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
LAMC3Laminin subunit gamma 3. (1527 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ACTN4Actinin alpha 4. (931 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
LAMB4Uncharacterized protein. (772 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
LAMC2Laminin subunit gamma 2. (1224 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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