STRINGSTRING
GSK3B GSK3B LIF LIF ID2 ID2 WNT1 WNT1 AKT1 AKT1 FZD4 FZD4 PCGF5 PCGF5 SOX2 SOX2 POU5F1 POU5F1 FZD5 FZD5 WNT6 WNT6 WNT2 WNT2 ACVR2A ACVR2A HAND1 HAND1 PCGF3 PCGF3 JAK3 JAK3 LHX5 LHX5 NEUROG1 NEUROG1 NANOG NANOG ACVR1 ACVR1 ID3 ID3 LIFR LIFR ESX1 ESX1 RIF1 RIF1 REST REST ZIC3 ZIC3 ISL1 ISL1 JAK2 JAK2 PIK3CA PIK3CA WNT8A WNT8A ACVR1C ACVR1C PIK3CD PIK3CD PCGF6 PCGF6 AXIN2 AXIN2 WNT11 WNT11 WNT9A WNT9A INHBB INHBB MAP2K2 MAP2K2 WNT10A WNT10A WNT5A WNT5A WNT16 WNT16 MYC MYC HESX1 HESX1 DLX5 DLX5 SETDB1 SETDB1 FGFR2 FGFR2 WNT9B WNT9B ONECUT1 ONECUT1 WNT2B WNT2B ID1 ID1 TCF3 TCF3 NRAS NRAS STAT3 STAT3 INHBE INHBE IGF1R IGF1R FZD6 FZD6 DVL2 DVL2 ACVR1B ACVR1B ESRRB ESRRB DVL3 DVL3 BMPR1B BMPR1B MAP2K1 MAP2K1 APC2 APC2 AKT3 AKT3 PIK3R1 PIK3R1 WNT8B WNT8B INHBA INHBA FZD9 FZD9 BMI1 BMI1 SMARCAD1 SMARCAD1 PAX6 PAX6 BMPR1A BMPR1A FZD7 FZD7 WNT4 WNT4 FZD2 FZD2 MAPK1 MAPK1 FGFR1 FGFR1 IGF1 IGF1 MAPK14 MAPK14 SMAD5 SMAD5 ACVR2B ACVR2B AXIN1 AXIN1 DUSP9 DUSP9 WNT3A WNT3A NODAL NODAL OTX1 OTX1 WNT3 WNT3 TBX3 TBX3 LOC104671592 LOC104671592 CTNNB1 CTNNB1 PIK3R3 PIK3R3 MAPK3 MAPK3 ZFHX3 ZFHX3 PCGF1 PCGF1 KRAS KRAS IL6ST IL6ST GRB2 GRB2 FZD10 FZD10 MYF5 MYF5 HRAS HRAS INHBC INHBC BMP4 BMP4 RAF1 RAF1 FGF2 FGF2 SMAD1 SMAD1 FZD3 FZD3 FGFR4 FGFR4 HOXB1 HOXB1 HOXA1 HOXA1 JARID2 JARID2 PCGF2 PCGF2 JAK1 JAK1 AKT2 AKT2 KAT6A KAT6A SKIL SKIL WNT7A WNT7A WNT7B WNT7B SMAD4 SMAD4 PIK3CB PIK3CB WNT10B WNT10B WNT5B WNT5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
SOX2SRY-box transcription factor 2. (319 aa)
POU5F1POU domain protein. (360 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
LHX5LIM homeobox 5. (376 aa)
NEUROG1Neurogenin 1. (238 aa)
NANOGHomeobox domain-containing protein. (297 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
ESX1Homeobox domain-containing protein. (392 aa)
RIF1Replication timing regulatory factor 1. (2471 aa)
RESTRE1 silencing transcription factor. (1096 aa)
ZIC3Zic family member 3. (466 aa)
ISL1ISL LIM homeobox 1. (349 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (396 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
AXIN2Axin 2. (843 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
INHBBInhibin subunit beta B. (396 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
HESX1HESX homeobox 1. (185 aa)
DLX5Distal-less homeobox 5. (289 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ONECUT1One cut domain family member. (465 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
TCF3Transcription factor 3. (655 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
INHBEInhibin subunit beta E. (351 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ESRRBEstrogen related receptor beta. (500 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
INHBAInhibin subunit beta A. (492 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
BMI1RING-type domain-containing protein. (339 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
PAX6Paired box 6. (458 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
FGFR1Fibroblast growth factor receptor. (872 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
AXIN1Axin 1. (867 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NODALNodal growth differentiation factor. (347 aa)
OTX1Orthodenticle homeobox 1. (288 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TBX3T-box transcription factor 3. (743 aa)
LOC104671592Homeobox domain-containing protein. (283 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ZFHX3Zinc finger homeobox 3. (3704 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
INHBCInhibin subunit beta C. (352 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RAF1Uncharacterized protein. (668 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
HOXB1Homeobox B1. (304 aa)
HOXA1Homeobox A1. (335 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
SKILSKI like proto-oncogene. (684 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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