STRINGSTRING
IFNB1 IFNB1 IL6 IL6 CD80 CD80 TLR3 TLR3 AKT1 AKT1 IKBKG IKBKG MAP2K7 MAP2K7 CXCL10 CXCL10 TICAM2 TICAM2 TLR7 TLR7 RELA RELA MAPK8 MAPK8 TNF TNF TLR2 TLR2 MAPK9 MAPK9 LBP LBP CD86 CD86 MYD88 MYD88 TAB2 TAB2 IRF7 IRF7 IL12B IL12B IRF5 IRF5 TLR8 TLR8 PIK3CA PIK3CA MAP2K6 MAP2K6 PIK3CD PIK3CD CASP8 CASP8 MAP2K2 MAP2K2 MAP3K7 MAP3K7 TAB1 TAB1 MAP2K4 MAP2K4 TLR4 TLR4 CCL4 CCL4 IRF3 IRF3 IFNAR2 IFNAR2 IFNAR1 IFNAR1 MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 RIPK1 RIPK1 IKBKE IKBKE CTSK CTSK MAPK1 MAPK1 MAP2K3 MAP2K3 LOC104664497 LOC104664497 IKBKB IKBKB LY96 LY96 MAPK14 MAPK14 IRAK4 IRAK4 NFKBIA NFKBIA SPP1 SPP1 MAPK10 MAPK10 CD14 CD14 FOS FOS PIK3R3 PIK3R3 MAPK3 MAPK3 CXCL11 CXCL11 STAT1 STAT1 TOLLIP TOLLIP IL1B IL1B FADD FADD CHUK CHUK TRAF6 TRAF6 IL12A IL12A IRAK1 IRAK1 TBK1 TBK1 AKT2 AKT2 MAP3K8 MAP3K8 PIK3CB PIK3CB TRAF3 TRAF3 TIRAP TIRAP CXCL8 CXCL8 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNB1Interferon beta 1. (187 aa)
IL6Interleukin 6. (214 aa)
CD80CD80 molecule. (288 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
CXCL10C-X-C motif chemokine. (98 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TLR2Toll-like receptor. (784 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
LBPLipopolysaccharide binding protein. (484 aa)
CD86CD86 molecule. (329 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF7Interferon regulatory factor 7. (503 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IRF5Interferon regulatory factor 5. (500 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CCL4C-C motif chemokine. (92 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
LOC104664497C-C motif chemokine. (71 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
LY96Lymphocyte antigen 96. (160 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
CD14CD14 molecule. (384 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CXCL11C-X-C motif chemokine. (94 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
TOLLIPToll interacting protein. (282 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
TBK1TANK binding kinase 1. (729 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
TIRAPTIR domain containing adaptor protein. (219 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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