STRINGSTRING
GABARAP GABARAP IFNB1 IFNB1 TXN2 TXN2 IL6 IL6 P2RX7 P2RX7 MEFV MEFV TP53BP1 TP53BP1 IKBKG IKBKG NOD1 NOD1 PKN1 PKN1 MFN1 MFN1 ANTXR2 ANTXR2 CARD8 CARD8 RELA RELA ENSRROP00000004228 ENSRROP00000004228 MAPK8 MAPK8 TNF TNF NOD2 NOD2 VDAC1 VDAC1 ATG16L1 ATG16L1 MAPK9 MAPK9 LOC104679033 LOC104679033 CASR CASR MYD88 MYD88 TAB2 TAB2 IRF9 IRF9 IRF7 IRF7 CASP5 CASP5 OAS3 OAS3 GPRC6A GPRC6A PRKCD PRKCD TYK2 TYK2 CASP8 CASP8 MAVS MAVS STAT2 STAT2 NFKBIB NFKBIB TRIP6 TRIP6 NLRP6 NLRP6 MAP3K7 MAP3K7 CYBB CYBB LOC104665277 LOC104665277 RHOA RHOA ENSRROP00000015910 ENSRROP00000015910 TAB1 TAB1 TRPM7 TRPM7 IFI16 IFI16 LOC104658882 LOC104658882 PANX1 PANX1 LOC104675522 LOC104675522 TLR4 TLR4 PSTPIP1 PSTPIP1 TRAF2 TRAF2 CTSB CTSB TRPM2 TRPM2 AIM2 AIM2 NLRC4 NLRC4 IRF3 IRF3 IFNAR2 IFNAR2 PLCB3 PLCB3 IFNAR1 IFNAR1 PKN2 PKN2 CARD6 CARD6 NLRX1 NLRX1 TRAF5 TRAF5 RIPK1 RIPK1 NAMPT NAMPT PLCB1 PLCB1 CASP4 CASP4 GBP7 GBP7 ITPR2 ITPR2 ANTXR1 ANTXR1 IKBKE IKBKE LOC104675524 LOC104675524 XIAP XIAP RNASEL RNASEL MAPK1 MAPK1 VDAC2 VDAC2 IKBKB IKBKB GABARAPL1 GABARAPL1 LOC104653610 LOC104653610 NLRP7 NLRP7 CXCL1 CXCL1 MAPK14 MAPK14 IRAK4 IRAK4 LOC104675523 LOC104675523 TXN TXN PLCB4 PLCB4 NFKBIA NFKBIA CARD9 CARD9 BCL2L1 BCL2L1 RBCK1 RBCK1 DHX33 DHX33 MAPK10 MAPK10 TXNIP TXNIP LOC104673370 LOC104673370 LOC104665273 LOC104665273 BRCC3 BRCC3 MAPK3 MAPK3 YWHAE YWHAE BIRC2 BIRC2 LOC104679032 LOC104679032 STAT1 STAT1 ERBIN ERBIN IL1B IL1B FADD FADD GBP3 GBP3 OAS2 OAS2 BCL2 BCL2 SHARPIN SHARPIN ITPR3 ITPR3 TNFAIP3 TNFAIP3 CYBA CYBA TANK TANK TAB3 TAB3 CASP1 CASP1 CHUK CHUK ATG5 ATG5 TRAF6 TRAF6 PYCARD PYCARD TBK1 TBK1 NAIP NAIP JAK1 JAK1 CAMP CAMP VDAC3 VDAC3 GABARAPL2 GABARAPL2 RIPK3 RIPK3 OAS1 OAS1 IL18 IL18 ATG12 ATG12 LOC104654807 LOC104654807 LOC104672237 LOC104672237 MCU MCU HSP90AB1 HSP90AB1 CXCL2 CXCL2 ITPR1 ITPR1 RNF31 RNF31 LOC104678684 LOC104678684 TRAF3 TRAF3 NLRP1 NLRP1 NEK7 NEK7 CXCL8 CXCL8 STING1 STING1 NFKB1 NFKB1 RIPK2 RIPK2 GBP1 GBP1 LOC104679035 LOC104679035 NLRP3 NLRP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABARAPGABA type A receptor-associated protein. (117 aa)
IFNB1Interferon beta 1. (187 aa)
TXN2Thioredoxin domain-containing protein. (166 aa)
IL6Interleukin 6. (214 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
MEFVMEFV innate immuity regulator, pyrin. (784 aa)
TP53BP1Tumor protein p53 binding protein 1. (1976 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
PKN1Protein kinase N1. (965 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa)
ANTXR2Anthrax toxin receptor; Belongs to the ATR family. (498 aa)
CARD8Uncharacterized protein. (444 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
ENSRROP00000004228CARD domain-containing protein. (94 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
LOC104679033Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa)
CASRCalcium sensing receptor. (1088 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF9Interferon regulatory factor 9. (392 aa)
IRF7Interferon regulatory factor 7. (503 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (446 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
GPRC6AG protein-coupled receptor class C group 6 member A. (928 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
MAVSCARD_2 domain-containing protein. (545 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
TRIP6Thyroid hormone receptor interactor 6. (476 aa)
NLRP6NLR family pyrin domain containing 6. (1041 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
LOC104665277CARD domain-containing protein. (91 aa)
RHOARas homolog family member A. (193 aa)
ENSRROP00000015910MPN domain-containing protein. (279 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
IFI16Interferon gamma inducible protein 16. (729 aa)
LOC104658882C-X-C motif chemokine. (107 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
LOC104675522Uncharacterized protein. (67 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (416 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
AIM2Absent in melanoma 2. (343 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
IFNAR2Uncharacterized protein. (516 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
PKN2Protein kinase N2. (983 aa)
CARD6Caspase recruitment domain family member 6. (931 aa)
NLRX1NLR family member X1. (972 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (499 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (377 aa)
GBP7Guanylate binding protein 7. (626 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ANTXR1Anthrax toxin receptor; Belongs to the ATR family. (564 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
LOC104675524Defensin_propep domain-containing protein. (93 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
RNASELRibonuclease L. (741 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
LOC104653610VWFA domain-containing protein. (287 aa)
NLRP7NLR family pyrin domain containing 7. (986 aa)
CXCL1C-X-C motif chemokine. (107 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LOC104675523DEFSN domain-containing protein. (64 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
BCL2L1BCL2 like 1. (233 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
DHX33DEAH-box helicase 33. (707 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
TXNIPThioredoxin interacting protein. (391 aa)
LOC104673370FIIND domain-containing protein. (457 aa)
LOC104665273Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
BRCC3MPN domain-containing protein. (297 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
LOC104679032DEFENSIN domain-containing protein. (96 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
ERBINErbb2 interacting protein. (1417 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
GBP3Guanylate binding protein 3. (595 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SHARPINSHANK associated RH domain interactor. (384 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
TANKTRAF family member associated NFKB activator. (457 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TBK1TANK binding kinase 1. (729 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
CAMPCathelicidin antimicrobial peptide. (173 aa)
VDAC3Uncharacterized protein. (284 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
OAS12'-5'-oligoadenylate synthetase 1. (415 aa)
IL18Interleukin 18. (211 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
LOC104654807C-X-C motif chemokine. (107 aa)
LOC104672237Thioredoxin domain-containing protein. (104 aa)
MCUMitochondrial calcium uniporter. (351 aa)
HSP90AB1HATPase_c domain-containing protein. (724 aa)
CXCL2C-X-C motif chemokine. (107 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
RNF31Uncharacterized protein. (1072 aa)
LOC104678684DEFSN domain-containing protein. (94 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
NLRP1NLR family pyrin domain containing 1. (1476 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (310 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
STING1Transmembrane protein 173. (379 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
GBP1Guanylate binding protein 1. (590 aa)
LOC104679035Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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