50 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFNB1	Interferon beta 1. (187 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (654 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MAPK9	Mitogen-activated protein kinase. (387 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	IRF7	Interferon regulatory factor 7. (503 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (723 aa)
	AZI2	5-azacytidine induced 2. (392 aa)
	TKFC	Triokinase and FMN cyclase. (575 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (542 aa)
	MAVS	CARD_2 domain-containing protein. (545 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	NFKBIB	NFKB inhibitor beta. (356 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
	IRF3	IRF tryptophan pentad repeat domain-containing protein. (426 aa)
	IFNE	Interferon epsilon. (196 aa)
	NLRX1	NLR family member X1. (972 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	DHX58	DExH-box helicase 58. (650 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1449 aa)
	OTUD5	OTU deubiquitinase 5. (479 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (343 aa)
	MAPK10	Mitogen-activated protein kinase. (550 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (167 aa)
	ISG15	ISG15 ubiquitin like modifier. (167 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	RNF125	Ring finger protein 125. (232 aa)
	TANK	TRAF family member associated NFKB activator. (457 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (522 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	STING1	Transmembrane protein 173. (379 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (975 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSRROP00000042363	ENSRROP00000038546	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP10	ENSRROP00000042363	ENSRROP00000043734	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 10; Belongs to the peptidase C14A family.	0.400
ATG12	CASP8	ENSRROP00000042363	ENSRROP00000013257	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.565
ATG12	DDX58	ENSRROP00000042363	ENSRROP00000010203	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.977
ATG12	FADD	ENSRROP00000042363	ENSRROP00000035006	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.703
ATG12	IFIH1	ENSRROP00000042363	ENSRROP00000013435	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.731
ATG12	MAVS	ENSRROP00000042363	ENSRROP00000013285	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	CARD_2 domain-containing protein.	0.977
ATG12	NLRX1	ENSRROP00000042363	ENSRROP00000022189	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.564
ATG5	ATG12	ENSRROP00000038546	ENSRROP00000042363	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSRROP00000038546	ENSRROP00000043734	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.583
ATG5	CASP8	ENSRROP00000038546	ENSRROP00000013257	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.722
ATG5	DDX58	ENSRROP00000038546	ENSRROP00000010203	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.977
ATG5	FADD	ENSRROP00000038546	ENSRROP00000035006	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.803
ATG5	IFIH1	ENSRROP00000038546	ENSRROP00000013435	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.697
ATG5	MAVS	ENSRROP00000038546	ENSRROP00000013285	Autophagy protein 5; Involved in autophagic vesicle formation.	CARD_2 domain-containing protein.	0.977
ATG5	NLRX1	ENSRROP00000038546	ENSRROP00000022189	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.575
ATG5	RIPK1	ENSRROP00000038546	ENSRROP00000022822	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.555
AZI2	CHUK	ENSRROP00000012518	ENSRROP00000037992	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.578
AZI2	IKBKB	ENSRROP00000012518	ENSRROP00000025159	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.578
AZI2	IKBKE	ENSRROP00000012518	ENSRROP00000023923	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.911