STRINGSTRING
LIF LIF CREBBP CREBBP IFNB1 IFNB1 IL21 IL21 IL6 IL6 IL4R IL4R SOCS1 SOCS1 PDGFB PDGFB STAT5A STAT5A IL20RA IL20RA AKT1 AKT1 SOCS5 SOCS5 SOCS6 SOCS6 SOCS4 SOCS4 JAK3 JAK3 SOCS3 SOCS3 IL12RB1 IL12RB1 IL5 IL5 CTF1-2 CTF1-2 LIFR LIFR PRLR PRLR IL2 IL2 LOC104676156 LOC104676156 PIAS1 PIAS1 IL7 IL7 IRF9 IRF9 JAK2 JAK2 IL12B IL12B PIK3CA PIK3CA IL3 IL3 IL10RB IL10RB STAT5B STAT5B PIK3CD PIK3CD CNTF CNTF CSF3 CSF3 TYK2 TYK2 IL22RA1 IL22RA1 STAM2 STAM2 SOS1 SOS1 STAT2 STAT2 TSLP TSLP IL22 IL22 CSF2RB CSF2RB GHR GHR CISH CISH PTPN11 PTPN11 IL21R IL21R PDGFA PDGFA MYC MYC IL2RA IL2RA LOC104675458 LOC104675458 PIAS4 PIAS4 CCND1 CCND1 PRL PRL IFNG IFNG LOC104675500 LOC104675500 STAT6 STAT6 IL13RA1 IL13RA1 LEP LEP STAT3 STAT3 MCL1 MCL1 GH1 GH1 IFNAR2 IFNAR2 IL24 IL24 IFNAR1 IFNAR1 IFNE IFNE IL5RA IL5RA LEPR LEPR LOC104670351 LOC104670351 AKT3 AKT3 PIK3R1 PIK3R1 IFNGR2 IFNGR2 IL15 IL15 GFAP GFAP IL10RA IL10RA IL3RA IL3RA IFNGR1 IFNGR1 CCND2 CCND2 EGF EGF CRLF2 CRLF2 PIAS3 PIAS3 MTOR MTOR IL27RA IL27RA STAM STAM SOCS7 SOCS7 IL2RG IL2RG SOS2 SOS2 IL6R IL6R CDKN1A CDKN1A BCL2L1 BCL2L1 FHL1 FHL1 EP300 EP300 PDGFRA PDGFRA OSM OSM PTPN6 PTPN6 IL13 IL13 IL13RA2 IL13RA2 IL12RB2 IL12RB2 PIM1 PIM1 PIK3R3 PIK3R3 IL19 IL19 IL9 IL9 IL6ST IL6ST CTF1 CTF1 IL7R IL7R STAT1 STAT1 GRB2 GRB2 CSF3R CSF3R BCL2 BCL2 CCND3 CCND3 HRAS HRAS CSF2RA CSF2RA IL11 IL11 EGFR EGFR RAF1 RAF1 IFNLR1 IFNLR1 PDGFRB PDGFRB CSF2 CSF2 ENSRROP00000038248 ENSRROP00000038248 IL4 IL4 PIAS2 PIAS2 IL12A IL12A EPOR EPOR AOX1 AOX1 GALT GALT JAK1 JAK1 AKT2 AKT2 LOC104670457 LOC104670457 CNTFR CNTFR IL23R IL23R IL9R IL9R IL2RB IL2RB IL20RB IL20RB THPO THPO IL10 IL10 MPL MPL OSMR OSMR IFNL1 IFNL1 PIK3CB PIK3CB LOC104676158 LOC104676158 SOCS2 SOCS2 STAT4 STAT4 IL20 IL20 EPO EPO IL23A IL23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIFLIF interleukin 6 family cytokine. (202 aa)
CREBBPCREB binding protein. (2442 aa)
IFNB1Interferon beta 1. (187 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL6Interleukin 6. (214 aa)
IL4RInterleukin 4 receptor. (825 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
IL20RAInterleukin 20 receptor subunit alpha. (548 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (661 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CTF1-2Uncharacterized protein. (152 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
LOC104676156Uncharacterized protein. (200 aa)
PIAS1Protein inhibitor of activated STAT 1. (653 aa)
IL7Interleukin 7. (178 aa)
IRF9Interferon regulatory factor 9. (392 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CSF3Colony stimulating factor 3. (204 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (571 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
IL22Interleukin 22. (179 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (897 aa)
GHRGrowth hormone receptor. (639 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IL21RUncharacterized protein. (373 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
LOC104675458Uncharacterized protein. (202 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
PRLProlactin. (228 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
LOC104675500Uncharacterized protein. (236 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (425 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
GH1Growth hormone-like protein 1. (217 aa)
IFNAR2Uncharacterized protein. (516 aa)
IL24Interleukin 24. (207 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
IFNEInterferon epsilon. (196 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
LEPRLeptin receptor. (1163 aa)
LOC104670351FAD-binding PCMH-type domain-containing protein. (1331 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (514 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
IL3RAInterleukin 3 receptor subunit alpha. (378 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
CRLF2Cytokine receptor like factor 2. (372 aa)
PIAS3Protein inhibitor of activated STAT 3. (634 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
STAMSignal transducing adaptor molecule. (540 aa)
SOCS7Suppressor of cytokine signaling 7. (584 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
IL6RInterleukin 6 receptor. (468 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BCL2L1BCL2 like 1. (233 aa)
FHL1Four and a half LIM domains 1. (339 aa)
EP300E1A binding protein p300. (2413 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
OSMOncostatin M. (252 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
IL13Interleukin 13. (146 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (339 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
PIM1Protein kinase domain-containing protein. (654 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
IL19Interleukin 19. (177 aa)
IL9Interleukin 9. (145 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
CTF1Uncharacterized protein. (202 aa)
IL7RInterleukin 7 receptor. (459 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CSF3RColony stimulating factor 3 receptor. (836 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (402 aa)
IL11Interleukin 11. (120 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RAF1Uncharacterized protein. (668 aa)
IFNLR1Interferon lambda receptor 1. (523 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CSF2Colony stimulating factor 2. (144 aa)
ENSRROP00000038248Uncharacterized protein. (216 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PIAS2Protein inhibitor of activated STAT 2. (620 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
AOX1Aldehyde oxidase 1. (1338 aa)
GALTUncharacterized protein. (746 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC104670457Uncharacterized protein. (1326 aa)
CNTFRCiliary neurotrophic factor receptor. (373 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL9RInterleukin 9 receptor. (514 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
THPOThrombopoietin. (353 aa)
IL10Interleukin 10. (178 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
OSMROncostatin M receptor. (977 aa)
IFNL1Interferon lambda 1. (202 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC104676158Uncharacterized protein. (200 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IL20Interleukin 20. (176 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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