79 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
	IL6	Interleukin 6. (214 aa)
	CXCL5	C-X-C motif chemokine. (114 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
	IL17F	Interleukin 17F. (163 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CCL7	C-C motif chemokine. (99 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IL17B	Interleukin 17B. (180 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	MAPK9	Mitogen-activated protein kinase. (387 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (114 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	TRAF4	TNF receptor-associated factor. (469 aa)
	IL17RB	Interleukin 17 receptor B. (490 aa)
	MMP1	Matrix metallopeptidase 1. (469 aa)
	CSF3	Colony stimulating factor 3. (204 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (542 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (572 aa)
	CCL17	C-C motif chemokine. (91 aa)
	MAPK4	Mitogen-activated protein kinase 4. (586 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
	LOC104658882	C-X-C motif chemokine. (107 aa)
	CCL20	C-C motif chemokine. (96 aa)
	CASP3	Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (755 aa)
	LOC104654808	C-X-C motif chemokine. (111 aa)
	IL25	Interleukin 25. (177 aa)
	CXCL6	C-X-C motif chemokine. (123 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	USP25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1125 aa)
	MAPK1	Mitogen-activated protein kinase. (330 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	CXCL1	C-X-C motif chemokine. (107 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	LOC104675523	DEFSN domain-containing protein. (64 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (343 aa)
	IL17C	Interleukin 17C. (197 aa)
	ELAVL1	ELAV-like protein; Belongs to the RRM elav family. (326 aa)
	MAPK10	Mitogen-activated protein kinase. (550 aa)
	MAPK15	Mitogen-activated protein kinase. (544 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	IL13	Interleukin 13. (146 aa)
	LCN2	Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (93 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	IL17A	Interleukin 17A. (155 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (804 aa)
	SRSF1	Uncharacterized protein. (253 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	MMP13	Matrix metallopeptidase 13. (503 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	IL17RA	Interleukin 17 receptor A. (864 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)
	MAPK6	Protein kinase domain-containing protein. (722 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	S100A7A	Protein S100; Belongs to the S-100 family. (101 aa)
	LOC104654807	C-X-C motif chemokine. (107 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (271 aa)
	HSP90AB1	HATPase_c domain-containing protein. (724 aa)
	CXCL2	C-X-C motif chemokine. (107 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	IL17RC	Interleukin 17 receptor C. (787 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (975 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP8	ENSRROP00000017230	ENSRROP00000013257	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.984
CASP3	FADD	ENSRROP00000017230	ENSRROP00000035006	Uncharacterized protein; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.631
CASP3	GSK3B	ENSRROP00000017230	ENSRROP00000000021	Uncharacterized protein; Belongs to the peptidase C14A family.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.404
CASP3	IL1B	ENSRROP00000017230	ENSRROP00000034785	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.572
CASP3	IL6	ENSRROP00000017230	ENSRROP00000001399	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin 6.	0.590
CASP3	MAPK1	ENSRROP00000017230	ENSRROP00000024767	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase.	0.935
CASP3	MAPK14	ENSRROP00000017230	ENSRROP00000025670	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase.	0.470
CASP3	MAPK3	ENSRROP00000017230	ENSRROP00000032094	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.947
CASP3	MAPK8	ENSRROP00000017230	ENSRROP00000004414	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase.	0.448
CASP3	NFKB1	ENSRROP00000017230	ENSRROP00000044836	Uncharacterized protein; Belongs to the peptidase C14A family.	Nuclear factor kappa B subunit 1.	0.444
CASP3	NFKBIA	ENSRROP00000017230	ENSRROP00000026557	Uncharacterized protein; Belongs to the peptidase C14A family.	ANK_REP_REGION domain-containing protein.	0.405
CASP3	PTGS2	ENSRROP00000017230	ENSRROP00000033580	Uncharacterized protein; Belongs to the peptidase C14A family.	Prostaglandin-endoperoxide synthase 2.	0.405
CASP3	TNF	ENSRROP00000017230	ENSRROP00000005240	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.563
CASP8	CASP3	ENSRROP00000013257	ENSRROP00000017230	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.984
CASP8	CHUK	ENSRROP00000013257	ENSRROP00000037992	Caspase 8; Belongs to the peptidase C14A family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.654
CASP8	FADD	ENSRROP00000013257	ENSRROP00000035006	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	IKBKB	ENSRROP00000013257	ENSRROP00000025159	Caspase 8; Belongs to the peptidase C14A family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.406
CASP8	IKBKG	ENSRROP00000013257	ENSRROP00000002136	Caspase 8; Belongs to the peptidase C14A family.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.787
CASP8	IL1B	ENSRROP00000013257	ENSRROP00000034785	Caspase 8; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.681
CASP8	IL6	ENSRROP00000013257	ENSRROP00000001399	Caspase 8; Belongs to the peptidase C14A family.	Interleukin 6.	0.430