STRINGSTRING
HLA-DOA HLA-DOA HIF1A HIF1A IL21 IL21 IL6 IL6 IL4R IL4R STAT5A STAT5A IKBKG IKBKG CD3D CD3D IL17F IL17F TGFBR2 TGFBR2 RELA RELA MAPK8 MAPK8 JAK3 JAK3 RXRG RXRG CD3G CD3G IL12RB1 IL12RB1 MAPK9 MAPK9 CD4 CD4 IL1RAP IL1RAP NFATC1 NFATC1 IL2 IL2 JAK2 JAK2 IL1R1 IL1R1 NFKBIE NFKBIE STAT5B STAT5B TYK2 TYK2 CD3E CD3E LCK LCK PPP3R1 PPP3R1 NFKBIB NFKBIB IL22 IL22 IL21R IL21R PPP3CB PPP3CB AHR AHR IL2RA IL2RA IFNG IFNG STAT6 STAT6 RARA RARA STAT3 STAT3 CD247 CD247 NFATC3 NFATC3 TBX21 TBX21 IFNGR2 IFNGR2 IFNGR1 IFNGR1 GATA3 GATA3 PRKCQ PRKCQ IRF4 IRF4 TGFBR1 TGFBR1 MAPK1 MAPK1 PLCG1 PLCG1 HLA-DPB1 HLA-DPB1 IKBKB IKBKB MTOR MTOR IL27RA IL27RA MAPK14 MAPK14 IL2RG IL2RG NFKBIA NFKBIA IL6R IL6R PPP3CC PPP3CC HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 MAPK10 MAPK10 FOS FOS FOXP3 FOXP3 MAPK3 MAPK3 LOC104666622 LOC104666622 HLA-DRA HLA-DRA IL6ST IL6ST STAT1 STAT1 IL17A IL17A IL1B IL1B ZAP70 ZAP70 RXRB RXRB CHUK CHUK IL4 IL4 RXRA RXRA NFATC2 NFATC2 TGFB1 TGFB1 JAK1 JAK1 IL23R IL23R IL2RB IL2RB RORA RORA SMAD4 SMAD4 HSP90AB1 HSP90AB1 NFKB1 NFKB1 IL23A IL23A PPP3CA PPP3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL6Interleukin 6. (214 aa)
IL4RInterleukin 4 receptor. (825 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CD3DCD3d molecule. (171 aa)
IL17FInterleukin 17F. (163 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
RXRGRetinoid X receptor gamma. (463 aa)
CD3GCD3g molecule. (181 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (661 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
CD4CD4 molecule. (458 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CD3ECD3e molecule. (198 aa)
LCKTyrosine-protein kinase. (561 aa)
PPP3R1Uncharacterized protein. (189 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
IL22Interleukin 22. (179 aa)
IL21RUncharacterized protein. (373 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
AHRUncharacterized protein. (850 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
RARARetinoic acid receptor alpha. (478 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
CD247CD247 molecule. (173 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
TBX21T-box transcription factor 21. (531 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
GATA3GATA binding protein 3. (444 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (710 aa)
IRF4Interferon regulatory factor 4. (450 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
IL6RInterleukin 6 receptor. (468 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
FOXP3Forkhead box P3. (454 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL17AInterleukin 17A. (155 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
RXRBRetinoid X receptor beta. (542 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
RXRARetinoid X receptor alpha. (481 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
RORARAR related orphan receptor A. (555 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
HSP90AB1HATPase_c domain-containing protein. (724 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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