STRINGSTRING
LIF LIF DAB2IP DAB2IP IFNB1 IFNB1 CASP7 CASP7 IL6 IL6 CXCL5 CXCL5 AKT1 AKT1 IKBKG IKBKG LTA LTA MAP2K7 MAP2K7 ATF6B ATF6B CXCL10 CXCL10 RELA RELA MAPK8 MAPK8 IL18R1 IL18R1 TNF TNF NOD2 NOD2 SOCS3 SOCS3 JUNB JUNB ATF4 ATF4 MAPK9 MAPK9 EDN1 EDN1 VCAM1 VCAM1 TAB2 TAB2 TNFRSF1A TNFRSF1A ATF2 ATF2 VEGFC VEGFC VEGFD VEGFD PIK3CA PIK3CA MAP2K6 MAP2K6 PIK3CD PIK3CD ITCH ITCH CASP8 CASP8 JAG1 JAG1 MAP3K5 MAP3K5 MAP3K7 MAP3K7 MMP14 MMP14 TAB1 TAB1 LOC104658882 LOC104658882 MAP2K4 MAP2K4 CCL20 CCL20 ICAM1 ICAM1 RPS6KA5 RPS6KA5 CASP3 CASP3 CREB5 CREB5 TRAF2 TRAF2 LOC104654808 LOC104654808 MAP2K1 MAP2K1 AKT3 AKT3 MAP3K14 MAP3K14 PIK3R1 PIK3R1 IL15 IL15 CSF1 CSF1 CXCL6 CXCL6 TRAF5 TRAF5 RIPK1 RIPK1 PGAM5 PGAM5 CREB3 CREB3 CREB1 CREB1 MAPK1 MAPK1 MAP2K3 MAP2K3 IKBKB IKBKB CXCL1 CXCL1 MAPK14 MAPK14 NFKBIA NFKBIA FAS FAS MAPK10 MAPK10 FOS FOS TNFRSF1B TNFRSF1B PIK3R3 PIK3R3 SELE SELE MAPK3 MAPK3 BIRC2 BIRC2 PTGS2 PTGS2 RPS6KA4 RPS6KA4 IL1B IL1B FADD FADD BAG4 BAG4 TNFAIP3 TNFAIP3 CREB3L1 CREB3L1 IRF1 IRF1 CX3CL1 CX3CL1 MLKL MLKL TAB3 TAB3 CSF2 CSF2 CHUK CHUK BCL3 BCL3 MMP3 MMP3 AKT2 AKT2 RIPK3 RIPK3 LOC104654807 LOC104654807 MAP3K8 MAP3K8 CFLAR CFLAR TRAF1 TRAF1 PIK3CB PIK3CB CASP10 CASP10 CXCL2 CXCL2 TRAF3 TRAF3 CREB3L2 CREB3L2 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIFLIF interleukin 6 family cytokine. (202 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
IFNB1Interferon beta 1. (187 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (336 aa)
IL6Interleukin 6. (214 aa)
CXCL5C-X-C motif chemokine. (114 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CXCL10C-X-C motif chemokine. (98 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ATF4Activating transcription factor 4. (351 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
EDN1Endothelin 1. (211 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LOC104658882C-X-C motif chemokine. (107 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
CCL20C-C motif chemokine. (96 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (670 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
LOC104654808C-X-C motif chemokine. (111 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
CXCL6C-X-C motif chemokine. (123 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (260 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
CXCL1C-X-C motif chemokine. (107 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
FASFas cell surface death receptor. (331 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SELESelectin E. (612 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
IRF1Interferon regulatory factor. (325 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
CSF2Colony stimulating factor 2. (144 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
BCL3BCL3 transcription coactivator. (454 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
LOC104654807C-X-C motif chemokine. (107 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
TRAF1TNF receptor-associated factor. (416 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (522 aa)
CXCL2C-X-C motif chemokine. (107 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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