STRINGSTRING
GSK3B GSK3B CAMK2D CAMK2D IRAK2 IRAK2 AKT1 AKT1 NGF NGF BRAF BRAF IRAK3 IRAK3 MAP2K7 MAP2K7 NTF3 NTF3 PDPK1 PDPK1 CAMK4 CAMK4 PRDM4 PRDM4 RELA RELA MAPK8 MAPK8 CALML3 CALML3 NTF4 NTF4 PSEN1 PSEN1 RPS6KA6 RPS6KA6 BAX BAX ATF4 ATF4 MAPK9 MAPK9 FOXO3 FOXO3 SHC4 SHC4 SORT1 SORT1 SH2B1 SH2B1 SH2B3 SH2B3 BEX3 BEX3 ARHGDIB ARHGDIB GAB1 GAB1 NFKBIE NFKBIE RAP1B RAP1B PIK3CA PIK3CA PRKCD PRKCD PIK3CD PIK3CD NTRK1 NTRK1 PSEN2 PSEN2 SOS1 SOS1 MAP3K5 MAP3K5 NFKBIB NFKBIB MAP2K2 MAP2K2 PTPN11 PTPN11 RHOA RHOA SHC1 SHC1 ABL1 ABL1 RPS6KA2 RPS6KA2 RPS6KA5 RPS6KA5 NGFR NGFR CAMK2A CAMK2A NRAS NRAS CALM3 CALM3 ENSRROP00000019822 ENSRROP00000019822 BAD BAD MAP2K1 MAP2K1 ARHGDIA ARHGDIA AKT3 AKT3 PIK3R1 PIK3R1 ARHGDIG ARHGDIG CRK CRK RPS6KA3 RPS6KA3 ENSRROP00000024190 ENSRROP00000024190 MAP3K1 MAP3K1 MAPK1 MAPK1 PLCG1 PLCG1 IKBKB IKBKB MAPK14 MAPK14 IRAK4 IRAK4 KIDINS220 KIDINS220 SOS2 SOS2 NFKBIA NFKBIA TP53 TP53 MAPK10 MAPK10 MAPKAPK2 MAPKAPK2 BDNF BDNF MATK MATK PIK3R3 PIK3R3 RPS6KA1 RPS6KA1 MAPK3 MAPK3 YWHAE YWHAE LOC104662055 LOC104662055 NTRK2 NTRK2 KRAS KRAS MAP3K3 MAP3K3 GRB2 GRB2 FRS2 FRS2 CAMK2B CAMK2B BCL2 BCL2 CDC42 CDC42 HRAS HRAS FASLG FASLG RAF1 RAF1 CAMK2G CAMK2G TRAF6 TRAF6 RAP1A RAP1A IRAK1 IRAK1 CRKL CRKL AKT2 AKT2 MAPK7 MAPK7 CALML6 CALML6 MAP2K5 MAP2K5 TP73 TP73 ZNF274 ZNF274 PIK3CB PIK3CB PLCG2 PLCG2 CALML4 CALML4 NFKB1 NFKB1 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (640 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (274 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
RPS6KA6Ribosomal protein S6 kinase. (732 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
ATF4Activating transcription factor 4. (351 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
FOXO3Forkhead box O3. (617 aa)
SHC4SHC adaptor protein 4. (630 aa)
SORT1Sortilin. (699 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
SH2B3SH2B adaptor protein 3. (596 aa)
BEX3Brain expressed X-linked 3. (123 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
RAP1BUncharacterized protein. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RHOARas homolog family member A. (193 aa)
SHC1SHC adaptor protein 1. (574 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RPS6KA2Protein kinase domain-containing protein. (200 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (670 aa)
NGFRNerve growth factor receptor. (427 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (204 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (269 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1449 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
KIDINS220Kinase D interacting substrate 220. (1777 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
MATKTyrosine-protein kinase. (554 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (653 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDC42Uncharacterized protein. (191 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
RAF1Uncharacterized protein. (668 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (559 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CALML6Calmodulin like 6. (181 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
ZNF274Zinc finger protein 274. (654 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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