STRINGSTRING
GSK3B GSK3B SOCS1 SOCS1 PCK2 PCK2 AKT1 AKT1 BRAF BRAF PPARGC1A PPARGC1A PDPK1 PDPK1 SOCS4 SOCS4 PPP1R3B PPP1R3B MAPK8 MAPK8 HK1 HK1 PPP1R3C PPP1R3C PRKAB2 PRKAB2 G6PC G6PC CALML3 CALML3 G6PC3 G6PC3 PRKACB PRKACB SOCS3 SOCS3 PYGM PYGM SLC2A4 SLC2A4 PHKA1 PHKA1 MAPK9 MAPK9 INPP5A INPP5A EXOC7 EXOC7 SHC4 SHC4 PRKAG2 PRKAG2 PRKACA PRKACA PIK3CA PIK3CA PHKA2 PHKA2 PIK3CD PIK3CD INPPL1 INPPL1 MKNK2 MKNK2 PDE3B PDE3B SOS1 SOS1 HK2 HK2 FLOT1 FLOT1 LIPE LIPE MAP2K2 MAP2K2 PRKAG3 PRKAG3 SHC1 SHC1 PHKB PHKB NRAS NRAS PRKAR1B PRKAR1B CALM3 CALM3 ACACA ACACA ENSRROP00000019822 ENSRROP00000019822 PHKG2 PHKG2 EIF4E EIF4E BAD BAD MAP2K1 MAP2K1 AKT3 AKT3 GYS1 GYS1 PIK3R1 PIK3R1 G6PC2 G6PC2 CRK CRK HKDC1 HKDC1 PYGB PYGB GCK GCK ENSRROP00000024190 ENSRROP00000024190 PPP1R3F PPP1R3F MAPK1 MAPK1 IKBKB IKBKB MTOR MTOR RPS6 RPS6 PRKAR1A PRKAR1A SOS2 SOS2 HK3 HK3 IRS4 IRS4 PPP1CB PPP1CB PKLR PKLR RPTOR RPTOR PRKAG1 PRKAG1 MAPK10 MAPK10 FBP1 FBP1 PRKAA1 PRKAA1 SREBF1 SREBF1 PRKCI PRKCI PPP1R3A PPP1R3A PIK3R3 PIK3R3 INSR INSR CBL CBL MAPK3 MAPK3 LOC104662055 LOC104662055 PPP1CA PPP1CA PTPRF PTPRF KRAS KRAS PCK1 PCK1 FBP2 FBP2 PRKAA2 PRKAA2 ACACB ACACB TSC1 TSC1 GRB2 GRB2 INS INS PPP1R3E PPP1R3E RPS6KB1 RPS6KB1 ELK1 ELK1 HRAS HRAS PRKAR2B PRKAR2B PRKAB1 PRKAB1 FOXO1 FOXO1 RHEB RHEB RAF1 RAF1 EIF4E1B EIF4E1B RHOQ RHOQ PRKAR2A PRKAR2A PTPN1 PTPN1 PRKCZ PRKCZ ARAF ARAF FASN FASN CRKL CRKL TSC2 TSC2 AKT2 AKT2 EIF4E2 EIF4E2 CBLB CBLB PPP1CC PPP1CC CALML6 CALML6 RPS6KB2 RPS6KB2 PIK3CB PIK3CB SOCS2 SOCS2 PYGL PYGL CALML4 CALML4 EIF4EBP1 EIF4EBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HK1Hexokinase 1. (921 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (725 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
SHC4SHC adaptor protein 4. (630 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1272 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1302 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
PDE3BPhosphodiesterase. (1113 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
HK2Hexokinase 2. (917 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
LIPELipase E, hormone sensitive type. (1054 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
SHC1SHC adaptor protein 1. (574 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
GCKPhosphotransferase. (466 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (665 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
HK3Hexokinase 3. (923 aa)
IRS4Insulin receptor substrate 4. (1227 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (409 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1143 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
CBLCbl proto-oncogene. (906 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1913 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
ACACBAcetyl-CoA carboxylase beta. (2442 aa)
TSC1TSC complex subunit 1. (1163 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ELK1Uncharacterized protein. (428 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (429 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
FOXO1Forkhead box O1. (585 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RAF1Uncharacterized protein. (668 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
RHOQUncharacterized protein. (184 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (465 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
FASNFatty acid synthase. (2504 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CBLBCbl proto-oncogene B. (982 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALML6Calmodulin like 6. (181 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
CALML4Calmodulin like 4. (192 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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