117 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (501 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	KRT24	Keratin 24; Belongs to the intermediate filament family. (522 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	ADCY5	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
	LOC104654549	IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	EBAG9	Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ENSRROP00000005686	IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
	KRT33B	Keratin 33B; Belongs to the intermediate filament family. (404 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	HSPA8-2	Uncharacterized protein. (129 aa)
	HSPA6	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (608 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	TFF1	Trefoil factor 1. (83 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	SP1	Sp1 transcription factor. (786 aa)
	KRT17	Keratin 17; Belongs to the intermediate filament family. (432 aa)
	LOC104658504	IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	KRT25	Keratin 25; Belongs to the intermediate filament family. (450 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
	KRT39	Keratin 39; Belongs to the intermediate filament family. (491 aa)
	SHC1	SHC adaptor protein 1. (574 aa)
	GABBR2	Gamma-aminobutyric acid type B receptor subunit 2. (922 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	KRT23	Keratin 23; Belongs to the intermediate filament family. (422 aa)
	RARA	Retinoic acid receptor alpha. (478 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	FKBP4	Peptidylprolyl isomerase. (459 aa)
	KRT38	Keratin 38; Belongs to the intermediate filament family. (452 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	GNAI1	G protein subunit alpha i1. (253 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	ENSRROP00000019822	Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
	SRC	Tyrosine-protein kinase. (540 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (414 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (550 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (594 aa)
	KRT32	Keratin 32; Belongs to the intermediate filament family. (448 aa)
	PGR	Progesterone receptor. (917 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	KRT28	Keratin 28; Belongs to the intermediate filament family. (464 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (468 aa)
	KRT31	IF rod domain-containing protein; Belongs to the intermediate filament family. (416 aa)
	MAPK1	Mitogen-activated protein kinase. (330 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
	KRT12	Keratin 12; Belongs to the intermediate filament family. (495 aa)
	KRT19	IF rod domain-containing protein; Belongs to the intermediate filament family. (400 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	KRT34	Keratin 34; Belongs to the intermediate filament family. (429 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	KRT35	Keratin 35; Belongs to the intermediate filament family. (455 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	LOC104662055	EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
	ESR2	Estrogen receptor 2. (530 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NCOA2	Nuclear receptor coactivator. (1475 aa)
	KRT37	Keratin 37; Belongs to the intermediate filament family. (449 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	KRT40	Keratin 40; Belongs to the intermediate filament family. (431 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (804 aa)
	KRT9	Keratin 9; Belongs to the intermediate filament family. (624 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	KRT27	Keratin 27; Belongs to the intermediate filament family. (459 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (419 aa)
	RAF1	Uncharacterized protein. (668 aa)
	LOC104663799	Uncharacterized protein. (246 aa)
	TGFA	Transforming growth factor alpha. (166 aa)
	GNAS	GNAS complex locus. (1041 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
	FKBP5	Peptidylprolyl isomerase. (457 aa)
	CALML6	Calmodulin like 6. (181 aa)
	NCOA3	Nuclear receptor coactivator. (1418 aa)
	HSP90AB1	HATPase_c domain-containing protein. (724 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
	LOC104678360	Nuclear receptor domain-containing protein. (231 aa)
	KRT20	Keratin 20; Belongs to the intermediate filament family. (424 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
	CALML4	Calmodulin like 4. (192 aa)
	POMC	Proopiomelanocortin. (251 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (393 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSRROP00000009828	ENSRROP00000012552	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.485
ADCY1	ADCY3	ENSRROP00000009828	ENSRROP00000040934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.945
ADCY1	ADCY5	ENSRROP00000009828	ENSRROP00000003576	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.455
ADCY1	ADCY6	ENSRROP00000009828	ENSRROP00000040839	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.454
ADCY1	ADCY7	ENSRROP00000009828	ENSRROP00000036529	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.515
ADCY1	ADCY8	ENSRROP00000009828	ENSRROP00000000304	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY1	ADCY9	ENSRROP00000009828	ENSRROP00000026575	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.663
ADCY1	AKT1	ENSRROP00000009828	ENSRROP00000002071	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.692
ADCY1	AKT2	ENSRROP00000009828	ENSRROP00000040614	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.692
ADCY1	AKT3	ENSRROP00000009828	ENSRROP00000021339	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.692
ADCY1	CALM3	ENSRROP00000009828	ENSRROP00000019127	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.944
ADCY1	CALML3	ENSRROP00000009828	ENSRROP00000005181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.949
ADCY1	CALML4	ENSRROP00000009828	ENSRROP00000044765	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.938
ADCY1	CALML6	ENSRROP00000009828	ENSRROP00000041579	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.939
ADCY1	ENSRROP00000019822	ENSRROP00000009828	ENSRROP00000019822	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.944
ADCY1	GNAI1	ENSRROP00000009828	ENSRROP00000019417	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.807
ADCY1	GNAI2	ENSRROP00000009828	ENSRROP00000009860	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.799
ADCY1	GNAI3	ENSRROP00000009828	ENSRROP00000017699	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.807
ADCY1	GNAS	ENSRROP00000009828	ENSRROP00000038847	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.972
ADCY1	LOC104662055	ENSRROP00000009828	ENSRROP00000032255	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	EF-hand domain-containing protein; Belongs to the calmodulin family.	0.925