STRINGSTRING
VEGFB VEGFB ADCY8 ADCY8 AKT1 AKT1 GNGT1 GNGT1 COL4A3 COL4A3 NOS2 NOS2 MAP2K7 MAP2K7 ATF6B ATF6B RXFP4 RXFP4 TGFBR2 TGFBR2 ADCY5 ADCY5 RELA RELA MAPK8 MAPK8 PRKACB PRKACB GNB3 GNB3 ATF4 ATF4 MAPK9 MAPK9 EDN1 EDN1 COL4A1 COL4A1 SHC4 SHC4 GNG7 GNG7 ADCY1 ADCY1 GNAI2 GNAI2 ATF2 ATF2 VEGFC VEGFC VEGFD VEGFD GNG13 GNG13 PRKACA PRKACA NOS1 NOS1 PIK3CA PIK3CA PIK3CD PIK3CD ADCY2 ADCY2 MMP1 MMP1 SOS1 SOS1 COL4A4 COL4A4 MAP2K2 MAP2K2 GNB1 GNB1 EDNRB EDNRB SHC1 SHC1 RLN3 RLN3 MAP2K4 MAP2K4 CREB5 CREB5 GNAI3 GNAI3 NRAS NRAS GNAI1 GNAI1 PLCB3 PLCB3 SRC SRC MAP2K1 MAP2K1 NOS3 NOS3 AKT3 AKT3 PIK3R1 PIK3R1 COL3A1 COL3A1 PLCB1 PLCB1 CREB3 CREB3 CREB1 CREB1 GNA15 GNA15 RXFP1 RXFP1 TGFBR1 TGFBR1 MAPK1 MAPK1 RXFP2 RXFP2 MAPK14 MAPK14 INSL5 INSL5 SOS2 SOS2 PLCB4 PLCB4 NFKBIA NFKBIA ADCY9 ADCY9 GNG3 GNG3 ARRB1 ARRB1 MAPK10 MAPK10 FOS FOS COL4A2 COL4A2 MMP2 MMP2 PIK3R3 PIK3R3 ARRB2 ARRB2 GNB5 GNB5 MAPK3 MAPK3 GNG4 GNG4 KRAS KRAS GRB2 GRB2 GNG5 GNG5 HRAS HRAS GNB4 GNB4 ADCY7 ADCY7 CREB3L1 CREB3L1 EGFR EGFR RAF1 RAF1 MMP13 MMP13 LOC104663799 LOC104663799 GNG11 GNG11 GNAS GNAS PRKCZ PRKCZ TGFB1 TGFB1 AKT2 AKT2 GNB2 GNB2 RLN2 RLN2 ADCY6 ADCY6 ADCY3 ADCY3 VEGFA VEGFA COL4A6 COL4A6 COL1A2 COL1A2 GNG12 GNG12 PRKCA PRKCA COL1A1 COL1A1 PIK3CB PIK3CB GNG8 GNG8 CREB3L2 CREB3L2 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
RXFP4Relaxin family peptide/INSL5 receptor 4. (373 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB3G protein subunit beta 3. (340 aa)
ATF4Activating transcription factor 4. (351 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
EDN1Endothelin 1. (211 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
SHC4SHC adaptor protein 4. (630 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNG13G protein subunit gamma 13. (67 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
GNB1G protein subunit beta 1. (340 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
SHC1SHC adaptor protein 1. (574 aa)
RLN3Relaxin 3. (142 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNAI3G protein subunit alpha i3. (354 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI1G protein subunit alpha i1. (253 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
SRCTyrosine-protein kinase. (540 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNA15G protein subunit alpha 15. (374 aa)
RXFP1Relaxin family peptide receptor 1. (779 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
RXFP2Relaxin family peptide receptor 2. (748 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
INSL5Insulin like 5. (135 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ARRB1Arrestin beta 1. (473 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ARRB2Arrestin beta 2. (453 aa)
GNB5G protein subunit beta 5. (403 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNB4G protein subunit beta 4. (340 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RAF1Uncharacterized protein. (668 aa)
MMP13Matrix metallopeptidase 13. (503 aa)
LOC104663799Uncharacterized protein. (246 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNASGNAS complex locus. (1041 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB2G protein subunit beta 2. (340 aa)
RLN2Relaxin 2. (185 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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