93 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1043 aa)
	MEF2D	Myocyte enhancer factor 2D. (521 aa)
	PLD1-2	Uncharacterized protein. (57 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (761 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	ADCY5	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	PDE4B	Phosphodiesterase. (564 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	PDE4D	Phosphodiesterase. (585 aa)
	GNA13	G protein subunit alpha 13. (308 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1561 aa)
	CASR	Calcium sensing receptor. (1088 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	SP1	Sp1 transcription factor. (786 aa)
	PDE4A	Phosphodiesterase. (886 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	KL	Klotho. (1018 aa)
	SLC34A1	Solute carrier family 34 member 1. (639 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
	GCM2	Glial cells missing transcription factor 2. (506 aa)
	SLC34A2	Solute carrier family 34 member 2. (690 aa)
	MMP15	Matrix metallopeptidase 15. (669 aa)
	MMP17	Matrix metallopeptidase 17. (552 aa)
	RHOA	Ras homolog family member A. (193 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (729 aa)
	GNAI1	G protein subunit alpha i1. (253 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	MMP24	Matrix metallopeptidase 24. (645 aa)
	PRKCB	Non-specific serine/threonine protein kinase. (590 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (609 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	PTHLH	Parathyroid hormone like hormone. (209 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
	GATA3	GATA binding protein 3. (444 aa)
	MAPK1	Mitogen-activated protein kinase. (330 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
	FGFR1	Fibroblast growth factor receptor. (872 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
	ARRB1	Arrestin beta 1. (473 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (968 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	VDR	Vitamin D receptor. (477 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	ARRB2	Arrestin beta 2. (453 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	RXRB	Retinoid X receptor beta. (542 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	RAF1	Uncharacterized protein. (668 aa)
	MMP13	Matrix metallopeptidase 13. (503 aa)
	LOC104663799	Uncharacterized protein. (246 aa)
	PLD2	Phospholipase. (933 aa)
	GNAS	GNAS complex locus. (1041 aa)
	RXRA	Retinoid X receptor alpha. (481 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (603 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1147 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	SOST	Sclerostin. (213 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
	AKAP13	A-kinase anchoring protein 13. (2874 aa)
	GNA12	G protein subunit alpha 12. (381 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSRROP00000009828	ENSRROP00000012552	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.485
ADCY1	ADCY3	ENSRROP00000009828	ENSRROP00000040934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.945
ADCY1	ADCY5	ENSRROP00000009828	ENSRROP00000003576	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.455
ADCY1	ADCY6	ENSRROP00000009828	ENSRROP00000040839	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.454
ADCY1	ADCY7	ENSRROP00000009828	ENSRROP00000036529	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.515
ADCY1	ADCY8	ENSRROP00000009828	ENSRROP00000000304	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY1	ADCY9	ENSRROP00000009828	ENSRROP00000026575	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.663
ADCY1	GNAI1	ENSRROP00000009828	ENSRROP00000019417	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.807
ADCY1	GNAI2	ENSRROP00000009828	ENSRROP00000009860	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.799
ADCY1	GNAI3	ENSRROP00000009828	ENSRROP00000017699	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.807
ADCY1	GNAS	ENSRROP00000009828	ENSRROP00000038847	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.972
ADCY1	LOC104663799	ENSRROP00000009828	ENSRROP00000037956	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.903
ADCY1	PDE4A	ENSRROP00000009828	ENSRROP00000010692	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.738
ADCY1	PDE4B	ENSRROP00000009828	ENSRROP00000005764	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.717
ADCY1	PDE4D	ENSRROP00000009828	ENSRROP00000006602	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.717
ADCY1	PRKACA	ENSRROP00000009828	ENSRROP00000011512	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.932
ADCY1	PRKACB	ENSRROP00000009828	ENSRROP00000005551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.934
ADCY1	PRKCA	ENSRROP00000009828	ENSRROP00000042243	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.695
ADCY1	PRKCB	ENSRROP00000009828	ENSRROP00000020897	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.674
ADCY1	PRKCG	ENSRROP00000009828	ENSRROP00000017280	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.685