STRINGSTRING
SOCS1 SOCS1 SOCS4 SOCS4 MAPK8 MAPK8 HK1 HK1 TNF TNF SOCS3 SOCS3 SLC2A4 SLC2A4 KCNJ11 KCNJ11 MAPK9 MAPK9 PRKCE PRKCE PIK3CA PIK3CA PRKCD PRKCD PIK3CD PIK3CD CACNA1E CACNA1E ADIPOQ ADIPOQ HK2 HK2 PIK3R1 PIK3R1 CACNA1D CACNA1D HKDC1 HKDC1 GCK GCK MAPK1 MAPK1 IKBKB IKBKB MTOR MTOR SLC2A2 SLC2A2 HK3 HK3 IRS4 IRS4 PKLR PKLR MAPK10 MAPK10 CACNA1C CACNA1C PKM PKM PDX1 PDX1 ABCC8 ABCC8 PIK3R3 PIK3R3 INSR INSR MAPK3 MAPK3 INS INS PRKCZ PRKCZ CACNA1G CACNA1G CACNA1B CACNA1B PIK3CB PIK3CB SOCS2 SOCS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HK1Hexokinase 1. (921 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
HK2Hexokinase 2. (917 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
GCKPhosphotransferase. (466 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
HK3Hexokinase 3. (923 aa)
IRS4Insulin receptor substrate 4. (1227 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
CACNA1CCa_chan_IQ domain-containing protein. (829 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2301 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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