STRINGSTRING
GSK3B GSK3B GFPT2 GFPT2 IL6 IL6 PCK2 PCK2 AKT1 AKT1 PPARGC1A PPARGC1A PDPK1 PDPK1 PPP1R3B PPP1R3B RELA RELA MAPK8 MAPK8 PPP1R3C PPP1R3C PRKAB2 PRKAB2 G6PC G6PC TNF TNF G6PC3 G6PC3 CD36 CD36 SOCS3 SOCS3 PYGM PYGM SLC2A4 SLC2A4 RPS6KA6 RPS6KA6 MAPK9 MAPK9 TNFRSF1A TNFRSF1A PRKCE PRKCE OGT OGT PPARGC1B PPARGC1B PRKAG2 PRKAG2 CPT1B CPT1B PIK3CA PIK3CA PRKCD PRKCD PIK3CD PIK3CD PTEN PTEN PRKAG3 PRKAG3 PTPN11 PTPN11 RPS6KA2 RPS6KA2 CREB5 CREB5 GFPT1 GFPT1 STAT3 STAT3 MLX MLX TBC1D4 TBC1D4 PRKCB PRKCB SLC27A1 SLC27A1 NOS3 NOS3 AKT3 AKT3 GYS1 GYS1 PIK3R1 PIK3R1 G6PC2 G6PC2 CREB3 CREB3 CREB1 CREB1 RPS6KA3 RPS6KA3 PRKCQ PRKCQ PYGB PYGB ENSRROP00000024190 ENSRROP00000024190 IKBKB IKBKB MTOR MTOR SLC2A2 SLC2A2 NFKBIA NFKBIA PPP1CB PPP1CB SLC2A1 SLC2A1 PRKAG1 PRKAG1 MAPK10 MAPK10 PRKAA1 PRKAA1 SREBF1 SREBF1 CRTC2 CRTC2 PPP1R3A PPP1R3A PIK3R3 PIK3R3 INSR INSR RPS6KA1 RPS6KA1 PPP1CA PPP1CA PTPRF PTPRF PCK1 PCK1 NR1H2 NR1H2 PRKAA2 PRKAA2 ACACB ACACB MLXIP MLXIP INS INS PPP1R3E PPP1R3E RPS6KB1 RPS6KB1 SLC27A4 SLC27A4 PRKAB1 PRKAB1 CREB3L1 CREB3L1 FOXO1 FOXO1 PTPN1 PTPN1 CPT1A CPT1A PRKCZ PRKCZ SLC27A2 SLC27A2 AKT2 AKT2 SLC27A5 SLC27A5 PPP1CC PPP1CC AGT AGT SLC27A3 SLC27A3 RPS6KB2 RPS6KB2 PIK3CB PIK3CB PYGL PYGL TRIB3 TRIB3 CREB3L2 CREB3L2 NFKB1 NFKB1 OGA OGA NR1H3 NR1H3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
IL6Interleukin 6. (214 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (725 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
RPS6KA6Ribosomal protein S6 kinase. (732 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RPS6KA2Protein kinase domain-containing protein. (200 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
MLXMAX dimerization protein MLX. (298 aa)
TBC1D4Rab-GAP TBC domain-containing protein. (391 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (710 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
CRTC2CREB regulated transcription coactivator 2. (699 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1143 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1913 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
ACACBAcetyl-CoA carboxylase beta. (2442 aa)
MLXIPMLX interacting protein. (919 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SLC27A4Solute carrier family 27 member 4. (651 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
FOXO1Forkhead box O1. (585 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (465 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
SLC27A3Solute carrier family 27 member 3. (730 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
OGAO-GlcNAcase. (943 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (511 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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