STRINGSTRING
VEGFB VEGFB TGFB3 TGFB3 IL6 IL6 STAT5A STAT5A AKT1 AKT1 COL4A3 COL4A3 TGFBR2 TGFBR2 RELA RELA IL1A IL1A MAPK8 MAPK8 TNF TNF LOC104678914 LOC104678914 BAX BAX MAPK9 MAPK9 EDN1 EDN1 COL4A1 COL4A1 F3 F3 NFATC1 NFATC1 VCAM1 VCAM1 SERPINE1 SERPINE1 PRKCE PRKCE VEGFC VEGFC VEGFD VEGFD JAK2 JAK2 CDK4 CDK4 PIK3CA PIK3CA PRKCD PRKCD STAT5B STAT5B PIK3CD PIK3CD AGTR1 AGTR1 COL4A4 COL4A4 CYBB CYBB ICAM1 ICAM1 CASP3 CASP3 CCND1 CCND1 NRAS NRAS STAT3 STAT3 PLCD1 PLCD1 PLCB3 PLCB3 PRKCB PRKCB NOS3 NOS3 AKT3 AKT3 PIK3R1 PIK3R1 COL3A1 COL3A1 FN1 FN1 PLCB1 PLCB1 AGER AGER TGFBR1 TGFBR1 MAPK1 MAPK1 PLCG1 PLCG1 DIAPH1 DIAPH1 NOX1 NOX1 MAPK14 MAPK14 PLCB4 PLCB4 CDKN1B CDKN1B MAPK10 MAPK10 COL4A2 COL4A2 MMP2 MMP2 PIM1 PIM1 PIK3R3 PIK3R3 PLCE1 PLCE1 SELE SELE MAPK3 MAPK3 PLCD3 PLCD3 TGFB2 TGFB2 KRAS KRAS STAT1 STAT1 IL1B IL1B BCL2 BCL2 CDC42 CDC42 HRAS HRAS FOXO1 FOXO1 PRKCZ PRKCZ TGFB1 TGFB1 AKT2 AKT2 AGT AGT VEGFA VEGFA COL4A6 COL4A6 COL1A2 COL1A2 PRKCA PRKCA EGR1 EGR1 COL1A1 COL1A1 SMAD4 SMAD4 PIK3CB PIK3CB PLCG2 PLCG2 CXCL8 CXCL8 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC104678914NADPH oxidase 4. (353 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
EDN1Endothelin 1. (211 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
F3Coagulation factor III, tissue factor. (296 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
FN1Fibronectin 1. (2479 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
DIAPH1Diaphanous related formin 1. (1238 aa)
NOX1NADPH oxidase 1. (564 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PIM1Protein kinase domain-containing protein. (654 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
SELESelectin E. (612 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDC42Uncharacterized protein. (191 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FOXO1Forkhead box O1. (585 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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