STRINGSTRING
HLA-DOA HLA-DOA CD80 CD80 LTA LTA IL1A IL1A TNF TNF CD86 CD86 IL2 IL2 IL12B IL12B LOC104655732 LOC104655732 PTPRN2 PTPRN2 LOC104676775 LOC104676775 IFNG IFNG ICA1-2 ICA1-2 LOC104679638 LOC104679638 HLA-DPB1 HLA-DPB1 LOC104676771 LOC104676771 FAS FAS HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 PTPRN PTPRN PRF1 PRF1 LOC104666622 LOC104666622 HLA-DRA HLA-DRA INS INS IL1B IL1B FASLG FASLG HLA-E HLA-E IL12A IL12A GAD1 GAD1 GZMB GZMB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
CD80CD80 molecule. (288 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD86CD86 molecule. (329 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
LOC104655732Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (608 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (1015 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
ICA1-2AH domain-containing protein. (101 aa)
LOC104679638Glutamate decarboxylase 2. (305 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
FASFas cell surface death receptor. (331 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
PRF1Perforin 1. (555 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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