STRINGSTRING
H2BC3 H2BC3 LOC104681099 LOC104681099 HIST1H3I HIST1H3I LOC104674022 LOC104674022 H2AX H2AX LOC104678627 LOC104678627 LOC104666383 LOC104666383 LOC104667440 LOC104667440 LOC104663440 LOC104663440 SLC18A2 SLC18A2 HDAC7 HDAC7 H2AW H2AW LOC104671059 LOC104671059 GNGT1 GNGT1 H3C15 H3C15 H2AC7 H2AC7 BRAF BRAF H3-4 H3-4 ATF6B ATF6B LOC104655506 LOC104655506 LOC104659464 LOC104659464 CAMK4 CAMK4 LOC104663499 LOC104663499 ADCY5 ADCY5 FOSB FOSB H2AC4 H2AC4 LOC104663742 LOC104663742 H2BC14 H2BC14 CALML3 CALML3 PRKACB PRKACB LOC104666728 LOC104666728 GNB3 GNB3 H2AC14 H2AC14 H2BC5 H2BC5 H2AC20 H2AC20 LOC104670855 LOC104670855 H2BU1 H2BU1 H2BC11 H2BC11 LOC104676512 LOC104676512 H2AJ H2AJ HDAC3 HDAC3 H2AC21 H2AC21 CRH CRH ATF4 ATF4 H2AC6 H2AC6 SLC29A3 SLC29A3 GRIN3B GRIN3B LOC104671023 LOC104671023 LOC104680836 LOC104680836 SHC4 SHC4 ADORA2A ADORA2A SLC29A1 SLC29A1 GNG7 GNG7 GNAI2 GNAI2 HDAC5 HDAC5 ATF2 ATF2 H2BC18 H2BC18 GNG13 GNG13 PRKACA PRKACA LOC104659773 LOC104659773 GRIN3A GRIN3A SOS1 SOS1 SLC6A3 SLC6A3 PPP1R1B PPP1R1B GNB1 GNB1 SHC1 SHC1 CREB5 CREB5 GNAI3 GNAI3 HDAC2 HDAC2 NRAS NRAS ADORA2B ADORA2B CALM3 CALM3 GNAI1 GNAI1 ENSRROP00000019822 ENSRROP00000019822 MAP2K1 MAP2K1 NPY NPY CREB3 CREB3 CREB1 CREB1 SLC29A2 SLC29A2 PKIA PKIA HDAC4 HDAC4 LOC104659775 LOC104659775 MAPK1 MAPK1 H2AZ2 H2AZ2 H2BW2 H2BW2 SOS2 SOS2 DRD1 DRD1 GNG3 GNG3 PPP1CB PPP1CB HDAC10 HDAC10 DDC DDC CAMKK1 CAMKK1 LOC104677352 LOC104677352 HDAC11 HDAC11 BDNF BDNF MACROH2A2 MACROH2A2 GNB5 GNB5 MAOA MAOA MAPK3 MAPK3 LOC104662055 LOC104662055 H2AZ1 H2AZ1 PPP1CA PPP1CA GNG4 GNG4 NTRK2 NTRK2 KRAS KRAS SLC18A1 SLC18A1 GRB2 GRB2 MAOB MAOB GNG5 GNG5 HRAS HRAS GNB4 GNB4 CREB3L1 CREB3L1 RAF1 RAF1 LOC104663799 LOC104663799 GNG11 GNG11 GNAS GNAS PDYN PDYN HAT1 HAT1 ARAF ARAF GNB2 GNB2 HDAC6 HDAC6 PPP1CC PPP1CC TH TH CALML6 CALML6 DRD2 DRD2 GNG12 GNG12 H2BC15 H2BC15 GRIN2A GRIN2A CAMKK2 CAMKK2 GNG8 GNG8 CREB3L2 CREB3L2 CALML4 CALML4 GRIN2B GRIN2B HDAC8 HDAC8 MACROH2A1 MACROH2A1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104681099Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H3IHistone H3; Belongs to the histone H3 family. (136 aa)
LOC104674022Histone H3; Belongs to the histone H3 family. (136 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC104678627Histone H3; Belongs to the histone H3 family. (136 aa)
LOC104666383Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC104667440Histone H3; Belongs to the histone H3 family. (136 aa)
LOC104663440Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1021 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
LOC104671059Histone H2A; Belongs to the histone H2A family. (130 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
H3C15Histone H3; Belongs to the histone H3 family. (136 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
LOC104655506Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC104659464Histone H2A; Belongs to the histone H2A family. (131 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (274 aa)
LOC104663499Histone H2B; Belongs to the histone H2B family. (126 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (864 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
H2AC4Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC104663742Histone H2B; Belongs to the histone H2B family. (127 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
LOC104666728Histone H2B; Belongs to the histone H2B family. (126 aa)
GNB3G protein subunit beta 3. (340 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC104670855Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104676512Histone H3; Belongs to the histone H3 family. (136 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
CRHCorticotropin releasing hormone. (196 aa)
ATF4Activating transcription factor 4. (351 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
SLC29A3Solute carrier family 29 member 3. (475 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1037 aa)
LOC104671023Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC104680836Histone domain-containing protein. (136 aa)
SHC4SHC adaptor protein 4. (630 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (522 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI2G protein subunit alpha i2. (355 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
GNG13G protein subunit gamma 13. (67 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LOC104659773Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
GNB1G protein subunit beta 1. (340 aa)
SHC1SHC adaptor protein 1. (574 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNAI3G protein subunit alpha i3. (354 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNAI1G protein subunit alpha i1. (253 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NPYNeuropeptide Y. (97 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (90 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
LOC104659775Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
HDAC10Histone deacetylase 10. (673 aa)
DDCDopa decarboxylase. (494 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
HDAC11Histone deacetylase 11. (347 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
GNB5G protein subunit beta 5. (403 aa)
MAOAAmine oxidase. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAOBAmine oxidase. (520 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNB4G protein subunit beta 4. (340 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
RAF1Uncharacterized protein. (668 aa)
LOC104663799Uncharacterized protein. (246 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNASGNAS complex locus. (1041 aa)
PDYNProdynorphin. (254 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
GNB2G protein subunit beta 2. (340 aa)
HDAC6Histone deacetylase 6. (1258 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
THTyrosine hydroxylase. (532 aa)
CALML6Calmodulin like 6. (181 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CALML4Calmodulin like 4. (192 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
HDAC8Histone deacetylase 8. (231 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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