STRINGSTRING
IFNB1 IFNB1 TGFB3 TGFB3 IL6 IL6 AKT1 AKT1 IKBKG IKBKG CD3D CD3D NOS2 NOS2 TGFBR2 TGFBR2 RELA RELA MAPK8 MAPK8 TNF TNF CD3G CD3G TLR2 TLR2 MAPK9 MAPK9 PPP2R2D PPP2R2D MYD88 MYD88 IL2 IL2 SERPINE1 SERPINE1 TNFRSF1A TNFRSF1A C1QC C1QC ADCY1 ADCY1 GNAI2 GNAI2 ACE ACE IL12B IL12B PIK3CA PIK3CA PIK3CD PIK3CD CD3E CD3E CASP8 CASP8 GNA11 GNA11 MAP2K4 MAP2K4 TLR4 TLR4 IFNG IFNG GNAI3 GNAI3 KNG1 KNG1 GNAL GNAL PPP2R1B PPP2R1B CD247 CD247 GNAI1 GNAI1 PLCB3 PLCB3 AKT3 AKT3 PIK3R1 PIK3R1 IFNGR2 IFNGR2 C1QA C1QA IFNGR1 IFNGR1 PLCB1 PLCB1 GNA15 GNA15 TGFBR1 TGFBR1 MAPK1 MAPK1 PPP2CA PPP2CA LOC104664497 LOC104664497 IKBKB IKBKB MAPK14 MAPK14 IRAK4 IRAK4 PLCB4 PLCB4 NFKBIA NFKBIA FAS FAS GNA14 GNA14 MAPK10 MAPK10 FOS FOS C1QB C1QB PPP2R1A PPP2R1A PIK3R3 PIK3R3 MAPK3 MAPK3 TGFB2 TGFB2 BDKRB2 BDKRB2 PPP2R2B PPP2R2B IL1B IL1B FADD FADD GNAQ GNAQ FASLG FASLG PPP2R2A PPP2R2A LOC104663799 LOC104663799 CHUK CHUK GNAS GNAS TRAF6 TRAF6 IL12A IL12A IRAK1 IRAK1 TGFB1 TGFB1 AKT2 AKT2 C3 C3 IL10 IL10 CALR CALR CFLAR CFLAR PIK3CB PIK3CB CXCL8 CXCL8 PPP2R2C PPP2R2C NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNB1Interferon beta 1. (187 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CD3DCD3d molecule. (171 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD3GCD3g molecule. (181 aa)
TLR2Toll-like receptor. (784 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
C1QCComplement C1q C chain. (239 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CD3ECD3e molecule. (198 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
GNA11G protein subunit alpha 11. (359 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
GNAI3G protein subunit alpha i3. (354 aa)
KNG1Kininogen 1. (644 aa)
GNALG protein subunit alpha L. (448 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
CD247CD247 molecule. (173 aa)
GNAI1G protein subunit alpha i1. (253 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
C1QAComplement C1q A chain. (245 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1114 aa)
GNA15G protein subunit alpha 15. (374 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LOC104664497C-C motif chemokine. (71 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1225 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
FASFas cell surface death receptor. (331 aa)
GNA14G protein subunit alpha 14. (355 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
C1QBComplement C1q B chain. (253 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
GNAQG protein subunit alpha q. (359 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
LOC104663799Uncharacterized protein. (246 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GNASGNAS complex locus. (1041 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
C3Complement C3. (1663 aa)
IL10Interleukin 10. (178 aa)
CALRCalreticulin. (417 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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