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HLA-DOA HLA-DOA LOC104679886 LOC104679886 CCR5 CCR5 HSPA1L HSPA1L LAMA4 LAMA4 TGFB3 TGFB3 LOC104681924 LOC104681924 SOCS1 SOCS1 AKT1 AKT1 IKBKG IKBKG ENSRROP00000002717 ENSRROP00000002717 NOS2 NOS2 PDPK1 PDPK1 RELA RELA MAPK8 MAPK8 TNF TNF TLR2 TLR2 LAMC1 LAMC1 LOC104661761 LOC104661761 MAPK9 MAPK9 HSPA8-2 HSPA8-2 HSPA6 HSPA6 LDLR LDLR ALOX5 ALOX5 MYD88 MYD88 TAB2 TAB2 TNFRSF1A TNFRSF1A GNAI2 GNAI2 PIK3R6 PIK3R6 JAK2 JAK2 IL12B IL12B MAP2K6 MAP2K6 IL10RB IL10RB TYK2 TYK2 CASP8 CASP8 NFKBIB NFKBIB MAP3K7 MAP3K7 LAMA1 LAMA1 PIK3CG PIK3CG TAB1 TAB1 CASP3 CASP3 TLR4 TLR4 IFNG IFNG GNAI3 GNAI3 LAMA3 LAMA3 STAT3 STAT3 CIITA CIITA GNAI1 GNAI1 BAD BAD AKT3 AKT3 IFNGR2 IFNGR2 IL10RA IL10RA IFNGR1 IFNGR1 LAMA5 LAMA5 ENSRROP00000024190 ENSRROP00000024190 XIAP XIAP PPIF PPIF MAPK1 MAPK1 MAP2K3 MAP2K3 HLA-DPB1 HLA-DPB1 ITGA6 ITGA6 IKBKB IKBKB LY96 LY96 MAPK14 MAPK14 IRAK4 IRAK4 LAMB2 LAMB2 NFKBIA NFKBIA HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 BCL2L1 BCL2L1 MAPK10 MAPK10 LAMB1 LAMB1 BIRC7 BIRC7 MAPK3 MAPK3 LOC104666622 LOC104666622 BIRC2 BIRC2 HLA-DRA HLA-DRA TGFB2 TGFB2 STAT1 STAT1 BCL2 BCL2 CD40LG CD40LG CASP9 CASP9 LAMB3 LAMB3 CHUK CHUK TRAF6 TRAF6 IL12A IL12A IRAK1 IRAK1 TGFB1 TGFB1 JAK1 JAK1 AKT2 AKT2 PIK3R5 PIK3R5 IL10 IL10 LAMC3 LAMC3 ITGB1 ITGB1 LAMB4 LAMB4 NFKB1 NFKB1 LAMC2 LAMC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TLR2Toll-like receptor. (784 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
HSPA8-2Uncharacterized protein. (129 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (608 aa)
LDLRLow density lipoprotein receptor. (855 aa)
ALOX5Arachidonate 5-lipoxygenase. (646 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
GNAI3G protein subunit alpha i3. (354 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
GNAI1G protein subunit alpha i1. (253 aa)
BADBCL2 associated agonist of cell death. (167 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
LY96Lymphocyte antigen 96. (160 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
BCL2L1BCL2 like 1. (233 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
LAMB1Laminin subunit beta 1. (1836 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
IL10Interleukin 10. (178 aa)
LAMC3Laminin subunit gamma 3. (1527 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMB4Uncharacterized protein. (772 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
LAMC2Laminin subunit gamma 2. (1224 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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