STRINGSTRING
HLA-DOA HLA-DOA LOC104679886 LOC104679886 CAMK2D CAMK2D CREBBP CREBBP IRAK2 IRAK2 IFNB1 IFNB1 PLA2R1 PLA2R1 TGFB3 TGFB3 IL6 IL6 LOC104681924 LOC104681924 AKT1 AKT1 ENSRROP00000002717 ENSRROP00000002717 NOS2 NOS2 CR1L CR1L RELA RELA IL1A IL1A MAPK8 MAPK8 ARHGEF12 ARHGEF12 CYP27B1 CYP27B1 CALML3 CALML3 TNF TNF CEBPG CEBPG NOD2 NOD2 ATP6AP1 ATP6AP1 TLR2 TLR2 BAX BAX LOC104661761 LOC104661761 MAPK9 MAPK9 LBP LBP ITGAM ITGAM RFXANK RFXANK NFYA NFYA MYD88 MYD88 ITGAX ITGAX TNFRSF1A TNFRSF1A JAK2 JAK2 IL12B IL12B IL10RB IL10RB LOC104655732 LOC104655732 CASP8 CASP8 PPP3R1 PPP3R1 SPHK1 SPHK1 RHOA RHOA PPP3CB PPP3CB RAB7A RAB7A CASP3 CASP3 TLR4 TLR4 IFNG IFNG RAB5C RAB5C CAMK2A CAMK2A CIITA CIITA EEA1 EEA1 CALM3 CALM3 LAMP2 LAMP2 PLK3 PLK3 ENSRROP00000019822 ENSRROP00000019822 SRC SRC SYK SYK BAD BAD CD74 CD74 RFX5 RFX5 AKT3 AKT3 IFNGR2 IFNGR2 ATP6V0A1 ATP6V0A1 IL10RA IL10RA APAF1 APAF1 IFNGR1 IFNGR1 CTSD CTSD TCIRG1 TCIRG1 HSPA9 HSPA9 CREB1 CREB1 SPHK2 SPHK2 RFXAP RFXAP MAPK1 MAPK1 HLA-DPB1 HLA-DPB1 MAPK14 MAPK14 IRAK4 IRAK4 CLEC4E CLEC4E PPP3CC PPP3CC HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 CARD9 CARD9 FCGR2B FCGR2B ATP6V0A4 ATP6V0A4 RAB5A RAB5A NFYB NFYB EP300 EP300 RAB5B RAB5B VDR VDR MAPK10 MAPK10 CD14 CD14 LSP1 LSP1 ATP6V0C ATP6V0C CR1 CR1 ATP6V0D2 ATP6V0D2 PIK3C3 PIK3C3 MAPK3 MAPK3 CTSS CTSS LOC104666622 LOC104666622 LOC104662055 LOC104662055 ATP6V1H ATP6V1H HLA-DRA HLA-DRA TGFB2 TGFB2 LOC104670100 LOC104670100 LAMP1 LAMP1 STAT1 STAT1 IL1B IL1B FADD FADD CAMK2B CAMK2B BCL2 BCL2 LOC104675809 LOC104675809 CASP9 CASP9 CD209 CD209 MRC2 MRC2 RAF1 RAF1 CORO1A CORO1A MRC1 MRC1 CAMK2G CAMK2G TRAF6 TRAF6 IL12A IL12A IRAK1 IRAK1 TGFB1 TGFB1 JAK1 JAK1 AKT2 AKT2 CAMP CAMP FCER1G FCER1G CALML6 CALML6 ATP6V0A2 ATP6V0A2 IL18 IL18 BCL10 BCL10 C3 C3 ITGB2 ITGB2 IL10 IL10 CASP10 CASP10 CLEC7A CLEC7A TIRAP TIRAP CALML4 CALML4 NFKB1 NFKB1 IL23A IL23A PPP3CA PPP3CA RIPK2 RIPK2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
CREBBPCREB binding protein. (2442 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (640 aa)
IFNB1Interferon beta 1. (187 aa)
PLA2R1Phospholipase A2 receptor 1. (1467 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
CR1LComplement C3b/C4b receptor 1 like. (568 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (467 aa)
TLR2Toll-like receptor. (784 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
LBPLipopolysaccharide binding protein. (484 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1198 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (260 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1154 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
LOC104655732Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (608 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
PPP3R1Uncharacterized protein. (189 aa)
SPHK1Sphingosine kinase 1. (472 aa)
RHOARas homolog family member A. (193 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
RAB5CRAB5C, member RAS oncogene family. (216 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
EEA1Early endosome antigen 1. (1411 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
SRCTyrosine-protein kinase. (540 aa)
SYKTyrosine-protein kinase. (635 aa)
BADBCL2 associated agonist of cell death. (167 aa)
CD74CD74 molecule. (294 aa)
RFX5Regulatory factor X5. (623 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (594 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
HSPA9Uncharacterized protein; Belongs to the heat shock protein 70 family. (679 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SPHK2Sphingosine kinase 2. (665 aa)
RFXAPRegulatory factor X associated protein. (272 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
FCGR2BUncharacterized protein. (313 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (836 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
EP300E1A binding protein p300. (2413 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
VDRVitamin D receptor. (477 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
CD14CD14 molecule. (384 aa)
LSP1Lymphocyte specific protein 1. (454 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CR1Complement C3b/C4b receptor 1 (Knops blood group). (2038 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC104670100Uncharacterized protein. (351 aa)
LAMP1Lysosomal associated membrane protein 1. (412 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (653 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC104675809Ig-like domain-containing protein. (192 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
CD209CD209 molecule. (379 aa)
MRC2Mannose receptor C type 2. (1479 aa)
RAF1Uncharacterized protein. (668 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
MRC1Mannose receptor C-type 1. (1448 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (559 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAMPCathelicidin antimicrobial peptide. (173 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
CALML6Calmodulin like 6. (181 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
IL18Interleukin 18. (211 aa)
BCL10BCL10 immune signaling adaptor. (316 aa)
C3Complement C3. (1663 aa)
ITGB2Integrin beta. (769 aa)
IL10Interleukin 10. (178 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (522 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
TIRAPTIR domain containing adaptor protein. (219 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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