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| | LOC104679886 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | LOC104681924 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | STAT5A | Signal transducer and activator of transcription. (905 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (761 aa) |
| | ENSRROP00000002717 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (403 aa) |
| | ATF6B | Activating transcription factor 6 beta. (708 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (234 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (914 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (467 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (197 aa) |
| | LOC104661761 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (387 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (895 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | IRF7 | Interferon regulatory factor 7. (503 aa) |
| | JAK2 | Tyrosine-protein kinase. (1094 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (723 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | TYK2 | Tyrosine-protein kinase. (1187 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (542 aa) |
| | MAVS | CARD_2 domain-containing protein. (545 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | STAT2 | Signal transducer and activator of transcription. (859 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (226 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | STAT3 | Signal transducer and activator of transcription. (802 aa) |
| | IRF3 | IRF tryptophan pentad repeat domain-containing protein. (426 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | SRC | Tyrosine-protein kinase. (540 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | PRKCB | Non-specific serine/threonine protein kinase. (590 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (372 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | RB1 | RB transcriptional corepressor 1. (929 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1449 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (330 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (343 aa) |
| | FAS | Fas cell surface death receptor. (331 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | EP300 | E1A binding protein p300. (2413 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (550 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4391 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | E2F1 | E2F transcription factor 1. (485 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | STAT1 | Signal transducer and activator of transcription. (787 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | ELK1 | Uncharacterized protein. (428 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1147 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (349 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | EGR2 | Early growth response 2. (476 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (707 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (932 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | VDAC3 | Uncharacterized protein. (284 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (522 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | TIRAP | TIR domain containing adaptor protein. (219 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (975 aa) |
