STRINGSTRING
HLA-DOA HLA-DOA LOC104679886 LOC104679886 CREBBP CREBBP BAK1 BAK1 RSAD2 RSAD2 IFNB1 IFNB1 LOC104657745 LOC104657745 IL6 IL6 LOC104681924 LOC104681924 TLR3 TLR3 KPNA5 KPNA5 AKT1 AKT1 IKBKG IKBKG ENSRROP00000002717 ENSRROP00000002717 CXCL10 CXCL10 LOC104675858 LOC104675858 PML PML TLR7 TLR7 RELA RELA IL1A IL1A KPNA1 KPNA1 TNFRSF10A TNFRSF10A TNF TNF SOCS3 SOCS3 VDAC1 VDAC1 NXT1 NXT1 BAX BAX LOC104661761 LOC104661761 TNFSF10 TNFSF10 ACTB ACTB MYD88 MYD88 TNFRSF1A TNFRSF1A ACTG1 ACTG1 IRF9 IRF9 LOC104675862 LOC104675862 DDX58 DDX58 IRF7 IRF7 JAK2 JAK2 OAS3 OAS3 CDK4 CDK4 CDK6 CDK6 IL12B IL12B HNRNPUL1 HNRNPUL1 EIF2S1 EIF2S1 PIK3CA PIK3CA DNAJC3 DNAJC3 PIK3CD PIK3CD TYK2 TYK2 CASP8 CASP8 MAVS MAVS IFIH1 IFIH1 STAT2 STAT2 NFKBIB NFKBIB MAP2K2 MAP2K2 MX2 MX2 NXF3 NXF3 NUP98 NUP98 TMPRSS11D TMPRSS11D ICAM1 ICAM1 TMPRSS2 TMPRSS2 CASP3 CASP3 TLR4 TLR4 IFNG IFNG CIITA CIITA MX1 MX1 IRF3 IRF3 IFNAR2 IFNAR2 ADAR ADAR IFNAR1 IFNAR1 KPNA2 KPNA2 PRKCB PRKCB MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 IFNGR2 IFNGR2 APAF1 APAF1 NLRX1 NLRX1 IFNGR1 IFNGR1 SLC25A4 SLC25A4 RAB11A RAB11A IL33 IL33 TMPRSS4 TMPRSS4 DNAJB1 DNAJB1 LOC104681498 LOC104681498 IKBKE IKBKE RNASEL RNASEL MAPK1 MAPK1 NXT2 NXT2 HLA-DPB1 HLA-DPB1 IKBKB IKBKB IRAK4 IRAK4 TRIM25 TRIM25 NFKBIA NFKBIA CPSF4L CPSF4L FAS FAS HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 LOC104661254 LOC104661254 EP300 EP300 KPNA7 KPNA7 SLC25A6 SLC25A6 XPO1 XPO1 PIK3R3 PIK3R3 FDPS FDPS LOC104665273 LOC104665273 MAPK3 MAPK3 LOC104666622 LOC104666622 HLA-DRA HLA-DRA EIF2AK2 EIF2AK2 STAT1 STAT1 IL1B IL1B FADD FADD OAS2 OAS2 CCND3 CCND3 FASLG FASLG CASP9 CASP9 RAF1 RAF1 CASP1 CASP1 CHUK CHUK PLG PLG IL12A IL12A PYCARD PYCARD TBK1 TBK1 TPSD1 TPSD1 JAK1 JAK1 AKT2 AKT2 NXF1 NXF1 OAS1 OAS1 IL18 IL18 PRKCA PRKCA RAE1 RAE1 PIK3CB PIK3CB TRAF3 TRAF3 KPNA6 KPNA6 CXCL8 CXCL8 LOC104655097 LOC104655097 NFKB1 NFKB1 NLRP3 NLRP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CREBBPCREB binding protein. (2442 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
IFNB1Interferon beta 1. (187 aa)
LOC104657745Uncharacterized protein. (611 aa)
IL6Interleukin 6. (214 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC104675858Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (296 aa)
PMLPromyelocytic leukemia. (882 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
TNFRSF10ATNF receptor superfamily member 10a. (469 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
ACTBActin beta. (375 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ACTG1Actin gamma 1. (375 aa)
IRF9Interferon regulatory factor 9. (392 aa)
LOC104675862Serine protease 1. (261 aa)
DDX58DExD/H-box helicase 58. (925 aa)
IRF7Interferon regulatory factor 7. (503 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
HNRNPUL1Heterogeneous nuclear ribonucleoprotein U like 1. (867 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (295 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
MAVSCARD_2 domain-containing protein. (545 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
NXF3Nuclear RNA export factor 3. (530 aa)
NUP98Nucleoporin 98. (1799 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (532 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (661 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
IFNAR2Uncharacterized protein. (516 aa)
ADARAdenosine deaminase RNA specific. (1241 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
KPNA2IBB domain-containing protein. (114 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
NLRX1NLR family member X1. (972 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
RAB11ARAB11A, member RAS oncogene family. (217 aa)
IL33Interleukin 33. (270 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
LOC104681498Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (282 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
RNASELRibonuclease L. (741 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
NXT2Nuclear transport factor 2 like export factor 2. (197 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRIM25Tripartite motif containing 25. (630 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (179 aa)
FASFas cell surface death receptor. (331 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
LOC104661254Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
EP300E1A binding protein p300. (2413 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (515 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
XPO1Exportin 1. (1071 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa)
LOC104665273Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (550 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
RAF1Uncharacterized protein. (668 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TBK1TANK binding kinase 1. (729 aa)
TPSD1Tryptase delta 1; Belongs to the peptidase S1 family. (242 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NXF1Nuclear RNA export factor 1. (619 aa)
OAS12'-5'-oligoadenylate synthetase 1. (415 aa)
IL18Interleukin 18. (211 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RAE1Ribonucleic acid export 1. (368 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (551 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC104655097Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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