STRINGSTRING
GSK3B GSK3B CREBBP CREBBP BAK1 BAK1 COL9A2 COL9A2 LAMA4 LAMA4 IFNB1 IFNB1 ITGB8 ITGB8 ATP6V1A ATP6V1A WNT1 WNT1 ITGAV ITGAV TLR3 TLR3 LOC104658905 LOC104658905 AKT1 AKT1 IKBKG IKBKG FZD4 FZD4 RBPJ RBPJ COL4A3 COL4A3 PATJ PATJ VTN VTN FZD5 FZD5 ATP6V1G2 ATP6V1G2 ITGA4 ITGA4 HES6 HES6 ATP6V1E2 ATP6V1E2 WNT6 WNT6 WNT2 WNT2 RELA RELA PARD6A PARD6A COL2A1 COL2A1 HEY2 HEY2 TNF TNF TNC TNC PRKACB PRKACB PSEN1 PSEN1 PPP2R5E PPP2R5E PPP2R5A PPP2R5A NFX1 NFX1 ATP6AP1 ATP6AP1 LAMC1 LAMC1 BAX BAX PPP2R2D PPP2R2D COL4A1 COL4A1 HES2 HES2 ITGB7 ITGB7 TNFRSF1A TNFRSF1A MAGI1 MAGI1 IRF9 IRF9 TCF7L1 TCF7L1 COL9A3 COL9A3 PARD3 PARD3 CDK4 CDK4 THBS3 THBS3 CDK6 CDK6 PRKACA PRKACA HEY1 HEY1 PIK3CA PIK3CA WNT8A WNT8A RFNG RFNG PIK3CD PIK3CD ITGA1 ITGA1 TYK2 TYK2 CASP8 CASP8 DLG1 DLG1 AXIN2 AXIN2 WNT11 WNT11 SOS1 SOS1 STAT2 STAT2 JAG1 JAG1 SCRIB SCRIB WNT9A WNT9A PTEN PTEN COL4A4 COL4A4 LOC104656442 LOC104656442 MAP2K2 MAP2K2 MX2 MX2 WNT10A WNT10A NOTCH4 NOTCH4 TUBG2 TUBG2 LAMA1 LAMA1 UBR4 UBR4 WNT5A WNT5A COL6A5 COL6A5 LLGL1 LLGL1 MPP5 MPP5 LOC104662560 LOC104662560 CCNE1 CCNE1 WNT16 WNT16 LOC104676775 LOC104676775 ITGA11 ITGA11 TERT TERT CASP3 CASP3 CCND1 CCND1 CREB5 CREB5 HDAC2 HDAC2 CSNK1A1 CSNK1A1 CCNE2 CCNE2 WNT9B WNT9B WNT2B WNT2B LAMA3 LAMA3 NRAS NRAS ITGA9 ITGA9 PPP2R1B PPP2R1B MX1 MX1 IRF3 IRF3 SLC9A3R1 SLC9A3R1 FZD6 FZD6 IFNAR2 IFNAR2 DVL2 DVL2 IFNAR1 IFNAR1 COL6A3 COL6A3 BAD BAD TNR TNR PTGER4 PTGER4 DVL3 DVL3 COL6A1 COL6A1 MAP2K1 MAP2K1 APC2 APC2 AKT3 AKT3 PIK3R1 PIK3R1 ITGB5 ITGB5 WNT8B WNT8B ATP6V0A1 ATP6V0A1 FN1 FN1 FZD9 FZD9 CCND2 CCND2 CRB3 CRB3 TCIRG1 TCIRG1 CREB3 CREB3 CREB1 CREB1 ATP6V0E1 ATP6V0E1 CCNA1 CCNA1 ITGB3 ITGB3 EGF EGF RB1 RB1 IBSP IBSP HEYL HEYL LAMA5 LAMA5 IKBKE IKBKE OASL OASL CCNA2 CCNA2 FZD7 FZD7 WNT4 WNT4 FZD2 FZD2 ATP6V1C1 ATP6V1C1 MAPK1 MAPK1 PPP2CA PPP2CA ITGA6 ITGA6 IKBKB IKBKB MTOR MTOR LAMB2 LAMB2 LOC104676771 LOC104676771 SOS2 SOS2 COL6A6 COL6A6 FAS FAS AXIN1 AXIN1 TNN TNN CDKN1B CDKN1B TBP TBP TP53 TP53 CDKN1A CDKN1A ATP6V0A4 ATP6V0A4 WNT3A WNT3A EP300 EP300 NOTCH2 NOTCH2 RELN RELN SPP1 SPP1 WNT3 WNT3 LOC104677352 LOC104677352 LOC104680681 LOC104680681 CHAD CHAD COL4A2 COL4A2 ITGA10 ITGA10 THBS2 THBS2 PKM PKM COL6A2 COL6A2 ATP6V0C ATP6V0C CTNNB1 CTNNB1 PRKCI PRKCI PPP2R1A PPP2R1A PIK3R3 PIK3R3 LFNG LFNG ATP6V1C2 ATP6V1C2 ATP6V0D2 ATP6V0D2 E2F1 E2F1 ATM ATM TUBG1 TUBG1 MAML3 MAML3 LAMB1 LAMB1 PPP2R3C PPP2R3C MFNG MFNG MAPK3 MAPK3 COL9A1 COL9A1 ATP6V1D ATP6V1D UBE3A UBE3A TBPL2 TBPL2 ATP6V1H ATP6V1H ATP6V1B1 ATP6V1B1 PTK2 PTK2 KRAS KRAS EIF2AK2 EIF2AK2 ISG15 ISG15 PPP2R2B PPP2R2B TBPL1 TBPL1 PTGS2 PTGS2 STAT1 STAT1 TSC1 TSC1 GRB2 GRB2 FZD10 FZD10 RPS6KB1 RPS6KB1 FADD FADD CDC42 CDC42 CCND3 CCND3 CSNK1A1L CSNK1A1L HRAS HRAS FASLG FASLG THBS4 THBS4 PPP2R5D PPP2R5D PPP2R2A PPP2R2A CREB3L1 CREB3L1 IRF1 IRF1 EGFR EGFR FOXO1 FOXO1 RHEB RHEB ITGA2B ITGA2B RAF1 RAF1 PDGFRB PDGFRB LAMB3 LAMB3 ITGA2 ITGA2 PPP2R5B PPP2R5B LOC104663799 LOC104663799 CHUK CHUK CHD4 CHD4 PPP2R5C PPP2R5C FZD3 FZD3 RBL1 RBL1 GNAS GNAS PPP2R3A PPP2R3A PRKCZ PRKCZ VWF VWF HLA-E HLA-E PARD6B PARD6B TBK1 TBK1 PARD6G PARD6G JAK1 JAK1 TSC2 TSC2 AKT2 AKT2 NOTCH1 NOTCH1 MAML2 MAML2 ATP6V1B2 ATP6V1B2 COMP COMP ITGA7 ITGA7 VEGFA VEGFA COL4A6 COL4A6 COL1A2 COL1A2 ATP6V0A2 ATP6V0A2 ITGA3 ITGA3 NOTCH3 NOTCH3 HES3 HES3 WNT7A WNT7A ITGA8 ITGA8 COL1A1 COL1A1 ITGB6 ITGB6 LLGL2 LLGL2 THBS1 THBS1 WNT7B WNT7B RPS6KB2 RPS6KB2 LAMC3 LAMC3 PIK3CB PIK3CB ITGB1 ITGB1 RBL2 RBL2 HES1 HES1 TADA3 TADA3 WNT10B WNT10B TRAF3 TRAF3 ATP6V1G1 ATP6V1G1 LAMB4 LAMB4 CREB3L2 CREB3L2 PPP2R2C PPP2R2C NFKB1 NFKB1 HES7 HES7 WNT5B WNT5B ITGA5 ITGA5 EIF4EBP1 EIF4EBP1 LAMC2 LAMC2 BCAP31 BCAP31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
CREBBPCREB binding protein. (2442 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
IFNB1Interferon beta 1. (187 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
ATP6V1AUncharacterized protein. (617 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
LOC104658905AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (493 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
PATJPATJ crumbs cell polarity complex component. (1883 aa)
VTNSMB domain-containing protein. (478 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
HES6Hes family bHLH transcription factor 6. (168 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (309 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNCTenascin C. (2201 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
NFX1Nuclear transcription factor, X-box binding 1. (1120 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (467 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
HES2Hes family bHLH transcription factor 2. (173 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1168 aa)
IRF9Interferon regulatory factor 9. (392 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
COL9A3Uncharacterized protein. (684 aa)
PARD3Par-3 family cell polarity regulator. (1325 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
THBS3Thrombospondin 3. (956 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (331 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
AXIN2Axin 2. (843 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
LOC104656442Uncharacterized protein. (2303 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
NOTCH4Notch receptor 4. (2037 aa)
TUBG2Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (459 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5182 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
COL6A5Collagen type VI alpha 5 chain. (1745 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1066 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LOC104662560Uncharacterized protein. (552 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1191 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (372 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (612 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (661 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
IFNAR2Uncharacterized protein. (516 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
COL6A3Collagen type VI alpha 3 chain. (3175 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TNRTenascin R. (1358 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
FN1Fibronectin 1. (2479 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CRB3Crumbs cell polarity complex component 3. (126 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
RB1RB transcriptional corepressor 1. (929 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
OASL2'-5'-oligoadenylate synthetase like. (515 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
FASFas cell surface death receptor. (331 aa)
AXIN1Axin 1. (867 aa)
TNNTenascin N. (1299 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TBPTATA-box binding protein. (333 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (836 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EP300E1A binding protein p300. (2413 aa)
NOTCH2Notch receptor 2. (2471 aa)
RELNUncharacterized protein. (879 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
LOC104680681Uncharacterized protein. (525 aa)
CHADChondroadherin. (359 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1168 aa)
THBS2Thrombospondin 2. (1172 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
COL6A2Collagen type VI alpha 2 chain. (1019 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (299 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
E2F1E2F transcription factor 1. (485 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
MAML3Mastermind like transcriptional coactivator 3. (1130 aa)
LAMB1Laminin subunit beta 1. (1836 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
ATP6V1DUncharacterized protein. (247 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
TBPL2TATA-box binding protein like 2. (376 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (550 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
TSC1TSC complex subunit 1. (1163 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CDC42Uncharacterized protein. (191 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CSNK1A1LCasein kinase 1 alpha 1 like. (243 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
THBS4Thrombospondin 4. (961 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
IRF1Interferon regulatory factor. (325 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FOXO1Forkhead box O1. (585 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
RAF1Uncharacterized protein. (668 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (596 aa)
LOC104663799Uncharacterized protein. (246 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CHD4Uncharacterized protein. (1913 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RBL1RB transcriptional corepressor like 1. (1033 aa)
GNASGNAS complex locus. (1041 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
VWFVon Willebrand factor. (2804 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
TBK1TANK binding kinase 1. (729 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TSC2TSC complex subunit 2. (1807 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOTCH1Notch receptor 1. (2560 aa)
MAML2Mastermind like transcriptional coactivator 2. (1151 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (538 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
NOTCH3Notch receptor 3. (2336 aa)
HES3Hes family bHLH transcription factor 3. (185 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
THBS1Thrombospondin 1. (1170 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
LAMC3Laminin subunit gamma 3. (1527 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
TADA3Transcriptional adaptor 3. (432 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LAMB4Uncharacterized protein. (772 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
HES7Hes family bHLH transcription factor 7. (214 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
LAMC2Laminin subunit gamma 2. (1224 aa)
BCAP31B cell receptor associated protein 31. (307 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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