STRINGSTRING
GSK3B GSK3B LOC104679886 LOC104679886 CCR5 CCR5 CREBBP CREBBP GABARAP GABARAP HIF1A HIF1A BAK1 BAK1 IFNB1 IFNB1 IL6 IL6 LOC104681924 LOC104681924 TLR3 TLR3 PDGFB PDGFB AKT1 AKT1 ATG3 ATG3 IKBKG IKBKG GNGT1 GNGT1 ENSRROP00000002717 ENSRROP00000002717 MAP2K7 MAP2K7 E2F3 E2F3 RELA RELA MAPK8 MAPK8 NFATC4 NFATC4 CALML3 CALML3 GNB3 GNB3 CCR4 CCR4 LYN LYN BAX BAX LOC104661761 LOC104661761 MAPK9 MAPK9 CD86 CD86 NFATC1 NFATC1 RCAN1 RCAN1 GNG7 GNG7 TNFRSF1A TNFRSF1A IRF9 IRF9 E2F2 E2F2 IRF7 IRF7 TCF7L1 TCF7L1 PIK3R6 PIK3R6 JAK2 JAK2 CDK4 CDK4 GNG13 GNG13 CDK6 CDK6 PIK3CA PIK3CA MAP2K6 MAP2K6 PIK3CD PIK3CD CCR1 CCR1 TYK2 TYK2 CASP8 CASP8 STAT2 STAT2 PPP3R1 PPP3R1 MAP2K2 MAP2K2 GNB1 GNB1 PIK3CG PIK3CG PPP3CB PPP3CB MYC MYC LOC104676775 LOC104676775 LOC104658882 LOC104658882 MAP2K4 MAP2K4 ICAM1 ICAM1 CASP3 CASP3 CCND1 CCND1 TRAF2 TRAF2 NRAS NRAS STAT3 STAT3 UBC UBC ATG14 ATG14 CALM3 CALM3 CCR3 CCR3 IRF3 IRF3 IFNAR2 IFNAR2 IFNAR1 IFNAR1 ENSRROP00000019822 ENSRROP00000019822 UBA52 UBA52 CLEC2B CLEC2B SRC SRC SYK SYK LOC104656725 LOC104656725 MAP2K1 MAP2K1 NFATC3 NFATC3 AKT3 AKT3 PIK3R1 PIK3R1 IFNGR1 IFNGR1 CREB1 CREB1 ITPR2 ITPR2 RB1 RB1 IKBKE IKBKE PREX1 PREX1 MAPK1 MAPK1 PLCG1 PLCG1 IKBKB IKBKB MTOR MTOR GABARAPL1 GABARAPL1 CXCL1 CXCL1 MAPK14 MAPK14 LOC104676771 LOC104676771 NFKBIA NFKBIA FAS FAS PPP3CC PPP3CC GNG3 GNG3 TP53 TP53 RPS27A RPS27A CDKN1A CDKN1A BECN1 BECN1 EP300 EP300 MAPK10 MAPK10 MAPKAPK2 MAPKAPK2 FOS FOS CTNNB1 CTNNB1 PIK3R3 PIK3R3 E2F1 E2F1 GNB5 GNB5 PIK3C3 PIK3C3 MAPK3 MAPK3 LOC104662055 LOC104662055 GNG4 GNG4 KRAS KRAS EIF2AK2 EIF2AK2 LEF1 LEF1 IL6ST IL6ST PTGS2 PTGS2 STAT1 STAT1 FADD FADD GNG5 GNG5 HRAS HRAS ITPR3 ITPR3 GNB4 GNB4 CASP9 CASP9 RAF1 RAF1 ZFP36 ZFP36 CSF2 CSF2 FGF2 FGF2 CHUK CHUK GNG11 GNG11 HLA-E HLA-E NFATC2 NFATC2 TBK1 TBK1 JAK1 JAK1 AKT2 AKT2 GNB2 GNB2 HCK HCK CALML6 CALML6 VEGFA VEGFA GABARAPL2 GABARAPL2 GNG12 GNG12 ANGPT2 ANGPT2 C3 C3 LOC104654807 LOC104654807 PIK3R5 PIK3R5 PIK3CB PIK3CB CXCL2 CXCL2 ITPR1 ITPR1 TRAF3 TRAF3 PLCG2 PLCG2 GNG8 GNG8 CXCL8 CXCL8 CALML4 CALML4 NFKB1 NFKB1 PPP3CA PPP3CA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CREBBPCREB binding protein. (2442 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IFNB1Interferon beta 1. (187 aa)
IL6Interleukin 6. (214 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ATG3Autophagy-related protein 3. (314 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
E2F3E2F transcription factor 3. (465 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNB3G protein subunit beta 3. (340 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LYNTyrosine-protein kinase. (491 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
CD86CD86 molecule. (329 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
RCAN1Regulator of calcineurin 1. (249 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IRF9Interferon regulatory factor 9. (392 aa)
E2F2E2F transcription factor 2. (437 aa)
IRF7Interferon regulatory factor 7. (503 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GNG13G protein subunit gamma 13. (67 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
GNB1G protein subunit beta 1. (340 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
LOC104658882C-X-C motif chemokine. (107 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
UBCUncharacterized protein. (351 aa)
ATG14Autophagy related 14. (492 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CLEC2BC-type lectin domain family 2 member B. (151 aa)
SRCTyrosine-protein kinase. (540 aa)
SYKTyrosine-protein kinase. (635 aa)
LOC104656725Ig-like domain-containing protein. (331 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
RB1RB transcriptional corepressor 1. (929 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1659 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
CXCL1C-X-C motif chemokine. (107 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
FASFas cell surface death receptor. (331 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BECN1Beclin 1. (450 aa)
EP300E1A binding protein p300. (2413 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F1E2F transcription factor 1. (485 aa)
GNB5G protein subunit beta 5. (403 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (550 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
GNB4G protein subunit beta 4. (340 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
RAF1Uncharacterized protein. (668 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
CSF2Colony stimulating factor 2. (144 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
TBK1TANK binding kinase 1. (729 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB2G protein subunit beta 2. (340 aa)
HCKTyrosine-protein kinase. (591 aa)
CALML6Calmodulin like 6. (181 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ANGPT2Angiopoietin 2. (510 aa)
C3Complement C3. (1663 aa)
LOC104654807C-X-C motif chemokine. (107 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CXCL2C-X-C motif chemokine. (107 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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