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HLA-DOA HLA-DOA LOC104679886 LOC104679886 CD58 CD58 BAK1 BAK1 SAP30 SAP30 IFNB1 IFNB1 IL6 IL6 LOC104681924 LOC104681924 LOC104658905 LOC104658905 AKT1 AKT1 IKBKG IKBKG RBPJ RBPJ CD3D CD3D ENSRROP00000002717 ENSRROP00000002717 MAP2K7 MAP2K7 CXCL10 CXCL10 NEDD4 NEDD4 E2F3 E2F3 PSMD8 PSMD8 RELA RELA MAPK8 MAPK8 JAK3 JAK3 TAP1 TAP1 TNF TNF CD3G CD3G SAP30L SAP30L LYN LYN TLR2 TLR2 BAX BAX LOC104661761 LOC104661761 MAPK9 MAPK9 MYD88 MYD88 TAB2 TAB2 IRF9 IRF9 DDX58 DDX58 E2F2 E2F2 IRF7 IRF7 B2M B2M OAS3 OAS3 CDK4 CDK4 PSMD7 PSMD7 CDK6 CDK6 NFKBIE NFKBIE PIK3CA PIK3CA MAP2K6 MAP2K6 BLNK BLNK ENTPD3 ENTPD3 PIK3CD PIK3CD TYK2 TYK2 CD3E CD3E CASP8 CASP8 MAVS MAVS STAT2 STAT2 RELB RELB NFKBIB NFKBIB ENTPD1 ENTPD1 MAP3K7 MAP3K7 PSMD11 PSMD11 TAB1 TAB1 CCNE1 CCNE1 MYC MYC LOC104676775 LOC104676775 MAP2K4 MAP2K4 GADD45A GADD45A PSMC6 PSMC6 ICAM1 ICAM1 CASP3 CASP3 CCND1 CCND1 PSMC2 PSMC2 HDAC2 HDAC2 CCNE2 CCNE2 TRAF2 TRAF2 STAT3 STAT3 TAP2 TAP2 CD247 CD247 IRF3 IRF3 IFNAR2 IFNAR2 IFNAR1 IFNAR1 BTK BTK SNW1 SNW1 SYK SYK NFKB2 NFKB2 AKT3 AKT3 PSMD14 PSMD14 MAP3K14 MAP3K14 PIK3R1 PIK3R1 APAF1 APAF1 PDIA3 PDIA3 CCND2 CCND2 TRAF5 TRAF5 RIPK1 RIPK1 CCNA1 CCNA1 RB1 RB1 PSMD3 PSMD3 IKBKE IKBKE CCNA2 CCNA2 MAP2K3 MAP2K3 HLA-DPB1 HLA-DPB1 IKBKB IKBKB MAPK14 MAPK14 IRAK4 IRAK4 LOC104676771 LOC104676771 NFKBIA NFKBIA FAS FAS PSMC4 PSMC4 CDKN1B CDKN1B TP53 TP53 HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 CDKN1A CDKN1A POLK POLK BCL2L11 BCL2L11 MAPK10 MAPK10 ITGAL ITGAL LOC104677352 LOC104677352 CIR1 CIR1 TAPBP TAPBP GADD45G GADD45G PIK3R3 PIK3R3 RUNX3 RUNX3 E2F1 E2F1 LOC104666622 LOC104666622 HLA-DRA HLA-DRA EIF2AK2 EIF2AK2 ISG15 ISG15 SKP2 SKP2 STAT1 STAT1 CD44 CD44 FADD FADD OAS2 OAS2 BCL2 BCL2 CCND3 CCND3 LOC104675809 LOC104675809 TNFAIP3 TNFAIP3 CASP9 CASP9 GADD45B GADD45B PSMC3 PSMC3 CHUK CHUK SEM1-2 SEM1-2 PSMD6 PSMD6 TRAF6 TRAF6 NCOR2 NCOR2 HLA-E HLA-E IRAK1 IRAK1 TBK1 TBK1 VIM VIM JAK1 JAK1 AKT2 AKT2 PSMC5 PSMC5 CR2 CR2 PSMD13 PSMD13 USP7 USP7 PSMD4 PSMD4 OAS1 OAS1 CALR CALR PSMD2 PSMD2 SIN3A SIN3A PIK3CB PIK3CB HES1 HES1 PSMD1 PSMD1 TRAF3 TRAF3 PLCG2 PLCG2 NFKB1 NFKB1 CD19 CD19
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD58CD58 molecule. (250 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
SAP30Sin3A associated protein 30. (124 aa)
IFNB1Interferon beta 1. (187 aa)
IL6Interleukin 6. (214 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC104658905AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (493 aa)
CD3DCD3d molecule. (171 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
CXCL10C-X-C motif chemokine. (98 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1083 aa)
E2F3E2F transcription factor 3. (465 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD3GCD3g molecule. (181 aa)
SAP30LSAP30 like. (188 aa)
LYNTyrosine-protein kinase. (491 aa)
TLR2Toll-like receptor. (784 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF9Interferon regulatory factor 9. (392 aa)
DDX58DExD/H-box helicase 58. (925 aa)
E2F2E2F transcription factor 2. (437 aa)
IRF7Interferon regulatory factor 7. (503 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BLNKB cell linker. (456 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CD3ECD3e molecule. (198 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
MAVSCARD_2 domain-containing protein. (545 aa)
STAT2Signal transducer and activator of transcription. (859 aa)
RELBRELB proto-oncogene, NF-kB subunit. (541 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (467 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (723 aa)
CD247CD247 molecule. (173 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
BTKTyrosine-protein kinase. (690 aa)
SNW1SNW domain containing 1. (536 aa)
SYKTyrosine-protein kinase. (635 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RB1RB transcriptional corepressor 1. (929 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
FASFas cell surface death receptor. (331 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1204 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
CIR1Cir_N domain-containing protein. (440 aa)
TAPBPTAP binding protein. (504 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (415 aa)
E2F1E2F transcription factor 1. (485 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (550 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
LOC104675809Ig-like domain-containing protein. (192 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (447 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
SEM1-2Uncharacterized protein. (89 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NCOR2Nuclear receptor corepressor 2. (2522 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
TBK1TANK binding kinase 1. (729 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (444 aa)
CR2Complement C3d receptor 2. (1093 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (399 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1102 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
OAS12'-5'-oligoadenylate synthetase 1. (415 aa)
CALRCalreticulin. (417 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
CD19CD19 molecule. (558 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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