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LOC104679886 LOC104679886 LOC104677263 LOC104677263 CCR5 CCR5 DCAF1 DCAF1 BAK1 BAK1 IFNB1 IFNB1 LOC104681924 LOC104681924 AKT1 AKT1 IKBKG IKBKG GNGT1 GNGT1 CD3D CD3D ENSRROP00000002717 ENSRROP00000002717 MAP2K7 MAP2K7 AP1S2 AP1S2 WEE2 WEE2 RELA RELA MAPK8 MAPK8 TAP1 TAP1 NFATC4 NFATC4 CALML3 CALML3 TNF TNF GNB3 GNB3 CD3G CD3G AP1M1 AP1M1 APOBEC3H APOBEC3H AP1G1 AP1G1 PAK2 PAK2 LOC104674456 LOC104674456 TLR2 TLR2 BAX BAX LOC104661761 LOC104661761 MAPK9 MAPK9 CD4 CD4 APOBEC3D APOBEC3D NFATC1 NFATC1 APOBEC3A APOBEC3A MYD88 MYD88 APOBEC3B APOBEC3B GNG7 GNG7 RBX1 RBX1 TAB2 TAB2 TNFRSF1A TNFRSF1A GNAI2 GNAI2 CXCR4 CXCR4 B2M B2M CUL1 CUL1 AP1B1 AP1B1 GNG13 GNG13 PIK3CA PIK3CA MAP2K6 MAP2K6 BTRC BTRC CUL4B CUL4B PIK3CD PIK3CD CD3E CD3E CASP8 CASP8 AP1S3 AP1S3 CCNB2 CCNB2 ELOC ELOC PPP3R1 PPP3R1 CUL5 CUL5 MAP2K2 MAP2K2 MAP3K7 MAP3K7 GNB1 GNB1 TAB1 TAB1 PPP3CB PPP3CB LOC104676775 LOC104676775 GNA11 GNA11 WEE1 WEE1 CASP3 CASP3 PRKCG PRKCG TLR4 TLR4 GNAI3 GNAI3 TRAF2 TRAF2 NRAS NRAS TAP2 TAP2 CALM3 CALM3 CD247 CD247 IRF3 IRF3 GNAI1 GNAI1 ENSRROP00000019822 ENSRROP00000019822 LOC104658196 LOC104658196 BAD BAD PRKCB PRKCB MAP2K1 MAP2K1 NFATC3 NFATC3 SAMHD1 SAMHD1 AKT3 AKT3 PIK3R1 PIK3R1 PDIA3 PDIA3 TRAF5 TRAF5 RIPK1 RIPK1 ITPR2 ITPR2 CRK CRK MAPK1 MAPK1 PLCG1 PLCG1 MAP2K3 MAP2K3 IKBKB IKBKB MTOR MTOR MAPK14 MAPK14 IRAK4 IRAK4 LOC104676771 LOC104676771 TRIM5 TRIM5 CFL2 CFL2 AP1M2 AP1M2 NFKBIA NFKBIA FAS FAS PPP3CC PPP3CC GNG3 GNG3 BCL2L1 BCL2L1 MAPK10 MAPK10 FOS FOS CFL1 CFL1 TNFRSF1B TNFRSF1B TAPBP TAPBP PIK3R3 PIK3R3 GNB5 GNB5 ATM ATM MAPK3 MAPK3 LOC104662055 LOC104662055 GNG4 GNG4 PTK2 PTK2 KRAS KRAS CUL4A CUL4A PAK4 PAK4 LIMK1 LIMK1 RPS6KB1 RPS6KB1 FADD FADD BCL2 BCL2 GNG5 GNG5 GNAQ GNAQ HRAS HRAS ITPR3 ITPR3 DDB1 DDB1 FASLG FASLG GNB4 GNB4 CGAS CGAS PAK6 PAK6 CASP9 CASP9 PAK5 PAK5 BST2 BST2 RAF1 RAF1 CHUK CHUK GNG11 GNG11 TRAF6 TRAF6 PTK2B PTK2B AP1S1 AP1S1 HLA-E HLA-E RAC2 RAC2 IRAK1 IRAK1 NFATC2 NFATC2 TBK1 TBK1 CDK1 CDK1 CRKL CRKL AKT2 AKT2 GNB2 GNB2 CALML6 CALML6 LIMK2 LIMK2 GNG12 GNG12 PRKCA PRKCA SKP1 SKP1 CALR CALR RPS6KB2 RPS6KB2 CCNB1 CCNB1 PIK3CB PIK3CB ITPR1 ITPR1 PLCG2 PLCG2 PAK1 PAK1 GNG8 GNG8 STING1 STING1 CALML4 CALML4 NFKB1 NFKB1 PPP3CA PPP3CA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC104677263Uncharacterized protein; Belongs to the SKP1 family. (155 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IFNB1Interferon beta 1. (187 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
CD3DCD3d molecule. (171 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
WEE2Wee1-like protein kinase. (567 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GNB3G protein subunit beta 3. (340 aa)
CD3GCD3g molecule. (181 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
APOBEC3HApolipoprotein B mRNA editing enzyme catalytic subunit 3H. (230 aa)
AP1G1AP-1 complex subunit gamma. (852 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LOC104674456Ubiquitin-like domain-containing protein. (118 aa)
TLR2Toll-like receptor. (784 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
CD4CD4 molecule. (458 aa)
APOBEC3DUncharacterized protein. (374 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
APOBEC3AUncharacterized protein. (382 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
APOBEC3BUncharacterized protein. (373 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RBX1Ring-box 1. (108 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
AP1B1AP complex subunit beta. (949 aa)
GNG13G protein subunit gamma 13. (67 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CD3ECD3e molecule. (198 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
PPP3R1Uncharacterized protein. (189 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
GNB1G protein subunit beta 1. (340 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
PPP3CBSerine/threonine-protein phosphatase. (521 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
GNA11G protein subunit alpha 11. (359 aa)
WEE1WEE1 G2 checkpoint kinase. (433 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (723 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CD247CD247 molecule. (173 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
GNAI1G protein subunit alpha i1. (253 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
LOC104658196CRIB domain-containing protein. (176 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (628 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
TRIM5Uncharacterized protein. (495 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
FASFas cell surface death receptor. (331 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BCL2L1BCL2 like 1. (233 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (212 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
TAPBPTAP binding protein. (504 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
GNB5G protein subunit beta 5. (403 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CUL4ACullin 4A; Belongs to the cullin family. (659 aa)
PAK4Non-specific serine/threonine protein kinase. (655 aa)
LIMK1LIM domain kinase 1. (677 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (359 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2703 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
GNB4G protein subunit beta 4. (340 aa)
CGASCyclic GMP-AMP synthase. (523 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
BST2Bone marrow stromal cell antigen 2. (182 aa)
RAF1Uncharacterized protein. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (166 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
RAC2Rac family small GTPase 2. (192 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
NFATC2Nuclear factor of activated T cells 2. (932 aa)
TBK1TANK binding kinase 1. (729 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB2G protein subunit beta 2. (340 aa)
CALML6Calmodulin like 6. (181 aa)
LIMK2LIM domain kinase 2. (639 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
CALRCalreticulin. (417 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2714 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
STING1Transmembrane protein 173. (379 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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