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H2BC3 H2BC3 LOC104681099 LOC104681099 CCR5 CCR5 CREBBP CREBBP BAK1 BAK1 LOC104663440 LOC104663440 HDAC7 HDAC7 STAT5A STAT5A PMAIP1 PMAIP1 LOC104658905 LOC104658905 IKBKG IKBKG RBPJ RBPJ ATF6B ATF6B LOC104663499 LOC104663499 LOC104663742 LOC104663742 RELA RELA MRPS18B MRPS18B JAK3 JAK3 H2BC14 H2BC14 PRKACB PRKACB GTF2E1 GTF2E1 LOC104666728 LOC104666728 H2BC5 H2BC5 GTF2B GTF2B LOC104670855 LOC104670855 H2BU1 H2BU1 H2BC11 H2BC11 CCR4 CCR4 LYN LYN HDAC3 HDAC3 BAX BAX REL REL ATF4 ATF4 RANBP1 RANBP1 IRF9 IRF9 HDAC5 HDAC5 ATF2 ATF2 GTF2H3 GTF2H3 IRF7 IRF7 H2BC18 H2BC18 CDC20 CDC20 CDK4 CDK4 CDK6 CDK6 PRKACA PRKACA LOC104659773 LOC104659773 DDX3X DDX3X PIK3CA PIK3CA STAT5B STAT5B PIK3CD PIK3CD CASP8 CASP8 DLG1 DLG1 SCIN SCIN POLB POLB SCRIB SCRIB KAT2B KAT2B HNRNPK HNRNPK GSN GSN RHOA RHOA UBR4 UBR4 YWHAB YWHAB CCNE1 CCNE1 LOC104676775 LOC104676775 HPN HPN CASP3 CASP3 CCND1 CCND1 YWHAZ YWHAZ CREB5 CREB5 HDAC2 HDAC2 CCNE2 CCNE2 SND1 SND1 TRAF2 TRAF2 NRAS NRAS STAT3 STAT3 CCR3 CCR3 IRF3 IRF3 SRC SRC SNW1 SNW1 SYK SYK BAD BAD NFKB2 NFKB2 SRF SRF PIK3R1 PIK3R1 YWHAG YWHAG CCND2 CCND2 TRAF5 TRAF5 CREB3 CREB3 CREB1 CREB1 CCNA1 CCNA1 RB1 RB1 DNAJA3 DNAJA3 GTF2A1 GTF2A1 CCNA2 CCNA2 HDAC4 HDAC4 LOC104659775 LOC104659775 MAPK1 MAPK1 LOC104676771 LOC104676771 H2BW2 H2BW2 NFKBIA NFKBIA CDKN1B CDKN1B TBP TBP TP53 TP53 CDKN2A CDKN2A CDKN1A CDKN1A ACTN1 ACTN1 CDKN2B CDKN2B KAT2A KAT2A EP300 EP300 HDAC10 HDAC10 LOC104677352 LOC104677352 MAPKAPK2 MAPKAPK2 HDAC11 HDAC11 PKM PKM EGR3 EGR3 GTF2H2 GTF2H2 PIK3R3 PIK3R3 ATP6V0D2 ATP6V0D2 RASA2 RASA2 MAPK3 MAPK3 YWHAE YWHAE ENSRROP00000032491 ENSRROP00000032491 UBE3A UBE3A TBPL2 TBPL2 KRAS KRAS EIF2AK2 EIF2AK2 IL6ST IL6ST TBPL1 TBPL1 SKP2 SKP2 GRB2 GRB2 CDC42 CDC42 CCND3 CCND3 HRAS HRAS DDB1 DDB1 CREB3L1 CREB3L1 LTBR LTBR GTF2A2 GTF2A2 CHD4 CHD4 GTF2E2 GTF2E2 EGR2 EGR2 RBL1 RBL1 YWHAH YWHAH HLA-E HLA-E CDK1 CDK1 JAK1 JAK1 VAC14 VAC14 HDAC6 HDAC6 MAD1L1 MAD1L1 VDAC3 VDAC3 USP7 USP7 GTF2H1 GTF2H1 C3 C3 H2BC15 H2BC15 YWHAQ YWHAQ TRAF1 TRAF1 PIK3CB PIK3CB RBL2 RBL2 ACTN4 ACTN4 TRAF3 TRAF3 CREB3L2 CREB3L2 GTF2H4 GTF2H4 NFKB1 NFKB1 HDAC8 HDAC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104681099Histone H2B; Belongs to the histone H2B family. (126 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CREBBPCREB binding protein. (2442 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
LOC104663440Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1021 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
PMAIP1Uncharacterized protein. (133 aa)
LOC104658905AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (493 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
LOC104663499Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104663742Histone H2B; Belongs to the histone H2B family. (127 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MRPS18BMitochondrial ribosomal protein S18B. (258 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GTF2E1General transcription factor IIE subunit 1. (439 aa)
LOC104666728Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
LOC104670855Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LYNTyrosine-protein kinase. (491 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
RELREL proto-oncogene, NF-kB subunit. (602 aa)
ATF4Activating transcription factor 4. (351 aa)
RANBP1RanBD1 domain-containing protein. (277 aa)
IRF9Interferon regulatory factor 9. (392 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
IRF7Interferon regulatory factor 7. (503 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
CDC20Cell division cycle 20. (499 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LOC104659773Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (723 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SCINScinderin. (715 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
HNRNPKUncharacterized protein. (464 aa)
GSNGelsolin. (807 aa)
RHOARas homolog family member A. (193 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5182 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (226 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (919 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
SRCTyrosine-protein kinase. (540 aa)
SNW1SNW domain containing 1. (536 aa)
SYKTyrosine-protein kinase. (635 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
SRFSerum response factor. (508 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RB1RB transcriptional corepressor 1. (929 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
GTF2A1General transcription factor IIA subunit 1. (370 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
LOC104659775Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
LOC104676771Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
NFKBIAANK_REP_REGION domain-containing protein. (343 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TBPTATA-box binding protein. (333 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ACTN1Actinin alpha 1. (930 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
EP300E1A binding protein p300. (2413 aa)
HDAC10Histone deacetylase 10. (673 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
HDAC11Histone deacetylase 11. (347 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
EGR3Early growth response 3. (387 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
RASA2RAS p21 protein activator 2. (832 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
ENSRROP00000032491RanBD1 domain-containing protein. (183 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
TBPL2TATA-box binding protein like 2. (376 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (550 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Uncharacterized protein. (191 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
LTBRLymphotoxin beta receptor. (461 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
CHD4Uncharacterized protein. (1913 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (289 aa)
EGR2Early growth response 2. (476 aa)
RBL1RB transcriptional corepressor like 1. (1033 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
HDAC6Histone deacetylase 6. (1258 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
VDAC3Uncharacterized protein. (284 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1102 aa)
GTF2H1General transcription factor IIH subunit 1. (557 aa)
C3Complement C3. (1663 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
TRAF1TNF receptor-associated factor. (416 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
ACTN4Actinin alpha 4. (931 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
HDAC8Histone deacetylase 8. (231 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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