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GSK3B GSK3B LOC104679886 LOC104679886 BAK1 BAK1 MSH2 MSH2 TGFB3 TGFB3 LOC104681924 LOC104681924 PMAIP1 PMAIP1 AKT1 AKT1 BRAF BRAF ENSRROP00000002717 ENSRROP00000002717 TGFBR2 TGFBR2 RALB RALB MAPK8 MAPK8 BAX BAX LOC104661761 LOC104661761 MAPK9 MAPK9 DCC DCC TCF7L1 TCF7L1 PIK3CA PIK3CA PIK3CD PIK3CD AXIN2 AXIN2 MSH3 MSH3 SOS1 SOS1 MAP2K2 MAP2K2 RHOA RHOA MYC MYC GADD45A GADD45A CASP3 CASP3 CCND1 CCND1 NRAS NRAS BAD BAD MAP2K1 MAP2K1 APC2 APC2 AKT3 AKT3 PIK3R1 PIK3R1 MSH6 MSH6 EGF EGF EREG EREG TGFBR1 TGFBR1 MAPK1 MAPK1 MLH1 MLH1 MTOR MTOR SOS2 SOS2 AXIN1 AXIN1 TP53 TP53 CDKN1A CDKN1A POLK POLK BCL2L11 BCL2L11 MAPK10 MAPK10 FOS FOS CTNNB1 CTNNB1 GADD45G GADD45G RALA RALA PIK3R3 PIK3R3 RALGDS RALGDS MAPK3 MAPK3 TGFB2 TGFB2 KRAS KRAS LEF1 LEF1 GRB2 GRB2 RPS6KB1 RPS6KB1 BCL2 BCL2 HRAS HRAS RGL4 RGL4 CASP9 CASP9 EGFR EGFR GADD45B GADD45B RAF1 RAF1 TGFA TGFA RAC2 RAC2 ARAF ARAF TGFB1 TGFB1 AREG AREG AKT2 AKT2 RPS6KB2 RPS6KB2 SMAD4 SMAD4 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
LOC104679886Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC104681924Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PMAIP1Uncharacterized protein. (133 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
ENSRROP00000002717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RALBRAS like proto-oncogene B. (206 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
LOC104661761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
DCCDCC netrin 1 receptor. (1065 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AXIN2Axin 2. (843 aa)
MSH3MutS homolog 3. (1195 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
RHOARas homolog family member A. (193 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
EREGEpiregulin. (163 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MLH1MutL homolog 1. (756 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
AXIN1Axin 1. (867 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RALARAS like proto-oncogene A. (206 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
RALGDSUncharacterized protein. (919 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RAF1Uncharacterized protein. (668 aa)
TGFATransforming growth factor alpha. (166 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AREGAmphiregulin. (274 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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