STRINGSTRING
BAK1 BAK1 RAD51 RAD51 TGFB3 TGFB3 PLD1-2 PLD1-2 AKT1 AKT1 IKBKG IKBKG BRAF BRAF TGFBR2 TGFBR2 E2F3 E2F3 RALB RALB RELA RELA MAPK8 MAPK8 ARHGEF6 ARHGEF6 BAX BAX MAPK9 MAPK9 E2F2 E2F2 RALBP1 RALBP1 CDK4 CDK4 CDK6 CDK6 PIK3CA PIK3CA PIK3CD PIK3CD GADD45A GADD45A CCND1 CCND1 STAT3 STAT3 BAD BAD MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 EGF EGF RB1 RB1 TGFBR1 TGFBR1 MAPK1 MAPK1 IKBKB IKBKB MTOR MTOR TP53 TP53 CDKN2A CDKN2A CDKN1A CDKN1A BCL2L1 BCL2L1 POLK POLK MAPK10 MAPK10 GADD45G GADD45G RALA RALA PIK3R3 PIK3R3 BRCA2 BRCA2 E2F1 E2F1 RALGDS RALGDS MAPK3 MAPK3 TGFB2 TGFB2 KRAS KRAS STAT1 STAT1 RPS6KB1 RPS6KB1 CDC42 CDC42 RGL4 RGL4 CASP9 CASP9 EGFR EGFR GADD45B GADD45B RAF1 RAF1 CHUK CHUK TGFA TGFA PLD2 PLD2 RAC2 RAC2 ARAF ARAF TGFB1 TGFB1 JAK1 JAK1 AKT2 AKT2 VEGFA VEGFA RPS6KB2 RPS6KB2 SMAD4 SMAD4 PIK3CB PIK3CB ERBB2 ERBB2 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1BCL2 antagonist/killer 1. (211 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PLD1-2Uncharacterized protein. (57 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
E2F3E2F transcription factor 3. (465 aa)
RALBRAS like proto-oncogene B. (206 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (555 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
E2F2E2F transcription factor 2. (437 aa)
RALBP1RalA binding protein 1. (655 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
RB1RB transcriptional corepressor 1. (929 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BCL2L1BCL2 like 1. (233 aa)
POLKDNA polymerase kappa. (870 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RALARAS like proto-oncogene A. (206 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
E2F1E2F transcription factor 1. (485 aa)
RALGDSUncharacterized protein. (919 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CDC42Uncharacterized protein. (191 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RAF1Uncharacterized protein. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TGFATransforming growth factor alpha. (166 aa)
PLD2Phospholipase. (933 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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