STRINGSTRING
GSK3B GSK3B BAK1 BAK1 CTNNA1 CTNNA1 AKT1 AKT1 BRAF BRAF PDPK1 PDPK1 CTNNA2 CTNNA2 BAX BAX FOXO3 FOXO3 TCF7L1 TCF7L1 LOC104662475 LOC104662475 PIK3CA PIK3CA PIK3CD PIK3CD AXIN2 AXIN2 SOS1 SOS1 PTEN PTEN MAP2K2 MAP2K2 MYC MYC GADD45A GADD45A CCND1 CCND1 NRAS NRAS BAD BAD MAP2K1 MAP2K1 APC2 APC2 AKT3 AKT3 PIK3R1 PIK3R1 EGF EGF ENSRROP00000024190 ENSRROP00000024190 MAPK1 MAPK1 MLH1 MLH1 SOS2 SOS2 AXIN1 AXIN1 TP53 TP53 CDKN1A CDKN1A POLK POLK CTNNB1 CTNNB1 GADD45G GADD45G PIK3R3 PIK3R3 MAPK3 MAPK3 KRAS KRAS LEF1 LEF1 GRB2 GRB2 ELK1 ELK1 HRAS HRAS CASP9 CASP9 EGFR EGFR GADD45B GADD45B CDH1 CDH1 RAF1 RAF1 ARAF ARAF AKT2 AKT2 PIK3CB PIK3CB ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CTNNA1Catenin alpha 1. (906 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
CTNNA2Catenin alpha 2. (919 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
FOXO3Forkhead box O3. (617 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
LOC104662475Uncharacterized protein. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AXIN2Axin 2. (843 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
MLH1MutL homolog 1. (756 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
AXIN1Axin 1. (867 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ELK1Uncharacterized protein. (428 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
RAF1Uncharacterized protein. (668 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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