STRINGSTRING
BAK1 BAK1 BRAF BRAF TPR TPR RXRG RXRG BAX BAX TCF7L1 TCF7L1 TPM3 TPM3 NTRK1 NTRK1 TFG TFG MAP2K2 MAP2K2 MYC MYC GADD45A GADD45A CCND1 CCND1 NRAS NRAS NCOA4 NCOA4 MAP2K1 MAP2K1 CCDC6 CCDC6 MAPK1 MAPK1 PAX8 PAX8 TP53 TP53 CDKN1A CDKN1A POLK POLK CTNNB1 CTNNB1 GADD45G GADD45G MAPK3 MAPK3 KRAS KRAS LEF1 LEF1 RET RET RXRB RXRB HRAS HRAS ENSRROP00000036580 ENSRROP00000036580 GADD45B GADD45B CDH1 CDH1 RXRA RXRA PPARG PPARG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1BCL2 antagonist/killer 1. (211 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
TPRTranslocated promoter region, nuclear basket protein. (2438 aa)
RXRGRetinoid X receptor gamma. (463 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
TPM3Uncharacterized protein; Belongs to the tropomyosin family. (285 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
TFGTrafficking from ER to golgi regulator. (400 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCDC6Coiled-coil domain containing 6. (474 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
PAX8Paired box 8. (486 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1094 aa)
RXRBRetinoid X receptor beta. (542 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSRROP00000036580Uncharacterized protein. (99 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
RXRARetinoid X receptor alpha. (481 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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