STRINGSTRING
GSK3B GSK3B PTCH1 PTCH1 BAK1 BAK1 PTCH2 PTCH2 WNT1 WNT1 FZD4 FZD4 FZD5 FZD5 WNT6 WNT6 WNT2 WNT2 BAX BAX TCF7L1 TCF7L1 BMP2 BMP2 SMO SMO WNT8A WNT8A AXIN2 AXIN2 WNT11 WNT11 WNT9A WNT9A WNT10A WNT10A WNT5A WNT5A SHH SHH WNT16 WNT16 GADD45A GADD45A KIF7 KIF7 WNT9B WNT9B WNT2B WNT2B HHIP HHIP FZD6 FZD6 DVL2 DVL2 DVL3 DVL3 GLI1 GLI1 APC2 APC2 WNT8B WNT8B FZD9 FZD9 GLI3 GLI3 FZD7 FZD7 WNT4 WNT4 FZD2 FZD2 AXIN1 AXIN1 TP53 TP53 CDKN1A CDKN1A WNT3A WNT3A POLK POLK WNT3 WNT3 CTNNB1 CTNNB1 GADD45G GADD45G LEF1 LEF1 FZD10 FZD10 GADD45B GADD45B BMP4 BMP4 FZD3 FZD3 WNT7A WNT7A WNT7B WNT7B WNT10B WNT10B WNT5B WNT5B GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
PTCH1Patched 1. (1448 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PTCH2Patched 2. (1203 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
AXIN2Axin 2. (843 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SHHHH_signal domain-containing protein. (141 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1342 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
HHIPHedgehog interacting protein. (700 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
GLI1GLI family zinc finger 1. (1106 aa)
APC2APC regulator of WNT signaling pathway 2. (2119 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
GLI3GLI family zinc finger 3. (1580 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
AXIN1Axin 1. (867 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
POLKDNA polymerase kappa. (870 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
GLI2GLI family zinc finger 2. (1586 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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